Relative fat mass as a predictor of gallstones: insights from national health and nutrition examination survey data

Friedman GD. Natural history of asymptomatic and symptomatic gallstones. Am J Surg. 1993;165:399–404.

Article  CAS  Google Scholar 

Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol. 2014;6:99–109.

Google Scholar 

Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver. 2012;6:172–87.

Article  Google Scholar 

Figueiredo JC, Haiman C, Porcel J, Buxbaum J, Stram D, Tambe N, Cozen W, Wilkens L, Le Marchand L, Setiawan VW. Sex and ethnic/racial-specific risk factors for gallbladder disease. BMC Gastroenterol. 2017;17:153.

Article  Google Scholar 

Shaffer EA. Gallstone disease: epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol. 2006;20:981–96.

Article  Google Scholar 

Marschall HU, Krawczyk M, Grunhage F, Katsika D, Einarsson C, Lammert F. Gallstone disease in Swedish twins is associated with the Gilbert variant of UGT1A1. Liver Int. 2013;33:904–8.

Article  Google Scholar 

Tanaka H, Imasato M, Yamazaki Y, Matsumoto K, Kunimoto K, Delpierre J, Meyer K, Zerial M, Kitamura N, Watanabe M, et al. Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. J Hepatol. 2018;69:1308–16.

Article  CAS  Google Scholar 

Paschos P, Paletas K. Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia. 2009;13:9–19.

CAS  Google Scholar 

Aune D, Norat T, Vatten LJ. Body mass index, abdominal fatness and the risk of gallbladder disease. Eur J Epidemiol. 2015;30:1009–19.

Article  Google Scholar 

Banim PJ, Luben RN, Bulluck H, Sharp SJ, Wareham NJ, Khaw KT, Hart AR. The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk. Epidemiological and biomarker data from a UK prospective cohort study (EPIC-Norfolk). Eur J Gastroenterol Hepatol. 2011;23:733–40.

Article  Google Scholar 

Oliveros E, Somers VK, Sochor O, Goel K, Lopez-Jimenez F. The concept of normal weight obesity. Prog Cardiovasc Dis. 2014;56:426–33.

Article  Google Scholar 

Safaei M, Sundararajan EA, Driss M, Boulila W, Shapi’i A. A systematic literature review on obesity: understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity. Comput Biol Med. 2021;136:104754.

Article  Google Scholar 

Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010;11:11–8.

Article  Google Scholar 

Woolcott OO, Bergman RN. Relative fat mass (RFM) as a new estimator of whole-body fat percentage horizontal line a cross-sectional study in American adult individuals. Sci Rep. 2018;8:10980.

Article  Google Scholar 

Efe SC, Karagoz A, Dogan C, Bayram Z, Kalkan S, Altintas MS, Yuksel Y, Karabag T, Ayca B, Ozdemir N. Relative Fat Mass Index can be solution for obesity paradox in coronary artery disease severity prediction calculated by SYNTAX score. Postgrad Med J. 2021;97:434–41.

Article  Google Scholar 

Caiano LM, Costanzo S, Panzera T, Di Castelnuovo A, de Gaetano G, Donati MB, Ageno W, Iacoviello L. Moli-Sani Study I: Association between body mass index, waist circumference, and relative fat mass with the risk of first unprovoked venous thromboembolism. Nutr Metab Cardiovasc Dis. 2021;31:3122–30.

Article  CAS  Google Scholar 

Suthahar N, Wang K, Zwartkruis VW, Bakker SJL, Inzucchi SE, Meems LMG, Eijgenraam TR, Ahmadizar F, Sijbrands EG, Gansevoort RT, et al. Associations of relative fat mass, a new index of adiposity, with type-2 diabetes in the general population. Eur J Intern Med. 2023;109:73–8.

Article  Google Scholar 

Yu P, Huang T, Hu S, Yu X. Predictive value of relative fat mass algorithm for incident hypertension: a 6-year prospective study in Chinese population. BMJ Open. 2020;10:e038420.

Article  Google Scholar 

Jin X, Xu J, Weng X. Correlation between ratio of fasting blood glucose to high density lipoprotein cholesterol in serum and non-alcoholic fatty liver disease in American adults: a population based analysis. Front Med (Lausanne). 2024;11:1428593.

Article  Google Scholar 

Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Central adiposity, regional fat distribution, and the risk of cholecystectomy in women. Gut. 2006;55:708–14.

Article  Google Scholar 

Hsu HY, Huang CY, Hwang LC. Sex difference of the predictive value of BMI, waist circumference and percentage body fat mass for gallstone disease. Br J Nutr. 2019;121:955–60.

Article  CAS  Google Scholar 

Bonfrate L, Wang DQ, Garruti G, Portincasa P: Obesity and the risk and prognosis of gallstone disease and pancreatitis. Best Pract Res Clin Gastroenterol. 2014;28:623–635

Park Y, Kim NH, Kwon TY, Kim SG. A novel adiposity index as an integrated predictor of cardiometabolic disease morbidity and mortality. Sci Rep. 2018;8:16753.

Article  Google Scholar 

Ke B, Sun Y, Dai X, Gui Y, Chen S. Relationship between weight-adjusted waist circumference index and prevalence of gallstones in U.S. adults: a study based on the NHANES 2017–2020. Front Endocrinol (Lausanne). 2023;14:1276465.

Article  Google Scholar 

Zhang J, Liang D, Xu L, Liu Y, Jiang S, Han X, Wu H, Jiang Y. Associations between novel anthropometric indices and the prevalence of gallstones among 6,848 adults: a cross-sectional study. Front Nutr. 2024;11:1428488.

Article  Google Scholar 

Correa CR, Formolo NPS, Dezanetti T, Speretta GFF, Nunes EA. Relative fat mass is a better tool to diagnose high adiposity when compared to body mass index in young male adults: a cross-section study. Clin Nutr ESPEN. 2021;41:225–33.

Article  Google Scholar 

Zhu X, Yue Y, Li L, Zhu L, Cai Y, Shu Y. The relationship between depression and relative fat mass (RFM): a population-based study. J Affect Disord. 2024;356:323–8.

Article  Google Scholar 

Cichosz SL, Rasmussen NH, Vestergaard P, Hejlesen O. Is predicted body-composition and relative fat mass an alternative to body-mass index and waist circumference for disease risk estimation? Diabetes Metab Syndr. 2022;16:102590.

Article  CAS  Google Scholar 

Shen W, Cai L, Wang B, Wang Y, Wang N, Lu Y. Associations of relative Fat Mass, a Novel Adiposity Indicator, with non-alcoholic fatty liver Disease and Cardiovascular Disease: data from SPECT-China. Diabetes Metab Syndr Obes. 2023;16:2377–87.

Article  CAS  Google Scholar 

Kobo O, Leiba R, Avizohar O, Karban A. Relative fat mass (RFM) as abdominal obesity criterion for metabolic syndrome. Eur J Intern Med. 2019;63:e9–11.

Article  CAS  Google Scholar 

Kobo O, Leiba R, Avizohar O, Karban A. Relative fat mass is a better predictor of dyslipidemia and metabolic syndrome than body mass index. Cardiovasc Endocrinol Metab. 2019;8:77–81.

Article  Google Scholar 

Suthahar N, Meems LMG, Withaar C, Gorter TM, Kieneker LM, Gansevoort RT, Bakker SJL, van Veldhuisen DJ, de Boer RA. Relative fat mass, a new index of adiposity, is strongly associated with incident heart failure: data from PREVEND. Sci Rep. 2022;12:147.

Article  CAS  Google Scholar 

Cortes VA, Barrera F, Nervi F. Pathophysiological connections between gallstone disease, insulin resistance, and obesity. Obes Rev. 2020;21:e12983.

Article  Google Scholar 

Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL. Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Nature. 2020;588:479–84.

Article  CAS  Google Scholar 

Tran KQ, Graewin SJ, Swartz-Basile DA, Nakeeb A, Svatek CL, Pitt HA. Leptin-resistant obese mice have paradoxically low biliary cholesterol saturation. Surgery. 2003;134:372–7.

Article  Google Scholar 

Wang SN, Yeh YT, Yu ML, Dai CY, Chi WC, Chung WL, Lee KT. Hyperleptinaemia and hypoadiponectinaemia are associated with gallstone disease. Eur J Clin Invest. 2006;36:176–80.

Article  CAS  Google Scholar 

Compagnucci AB, Perroud HA, Batalles SM, Villavicencio R, Brasca A, Berli D, Pezzotto SM. A nested case-control study on dietary fat consumption and the risk for gallstone disease. J Hum Nutr Diet. 2016;29:338–4.

Article  Google Scholar 

Nakano S, Suzuki M, Haruna H, Yamataka A, Shimizu T. Gallstone formation due to rapid weight loss through hyperthyroidism. J Pediatr Endocrinol Metab. 2019;32:1395–8.

Article  CAS  Google Scholar 

Yang H, Petersen GM, Roth MP, Schoenfield LJ, Marks JW. Risk factors for gallstone formation during rapid loss of weight. Dig Dis Sci. 1992;37:912–8.

Article  CAS  Google Scholar 

Sulaberidze G, Okujava M, Liluashvili K, Tughushi M, Bezarashvili S. Dietary fiber’s benefit for gallstone disease prevention during rapid weight loss in obese patients. Georgian Med News 2014:95–9.

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