Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

Article  PubMed  Google Scholar 

Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.

Article  PubMed  Google Scholar 

Horvath SE, Daum G. Lipids of mitochondria. Prog Lipid Res. 2013;52:590–614.

Article  CAS  PubMed  Google Scholar 

Paradies G, Paradies V, Ruggiero FM, Petrosillo G. Cardiolipin and mitochondrial function in health and disease. Antioxid Redox Signal. 2014;20:1925–53.

Article  CAS  PubMed  Google Scholar 

Zhang M, Mileykovskaya E, Dowhan W. Cardiolipin is essential for organization of complexes III and IV into a supercomplex in intact yeast mitochondria. J Biol Chem. 2005;280:29403–8.

Article  CAS  PubMed  Google Scholar 

Javadov S, Jang S, Chapa-Dubocq XR, Khuchua Z, Camara AK. Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role. J Mol Med. 2021;99:57–73.

Article  CAS  PubMed  Google Scholar 

Mileykovskaya E, Dowhan W. Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes. Chem Phys Lipids. 2014;179:42–8.

Article  CAS  PubMed  Google Scholar 

Venkatraman K, Lee CT, Garcia GC, Mahapatra A, Milshteyn D, Perkins G, et al. Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome. EMBO J. 2023;42:e114054.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kojima R, Kakimoto Y, Furuta S, Itoh K, Sesaki H, Endo T, et al. Maintenance of cardiolipin and crista structure requires cooperative functions of mitochondrial dynamics and phospholipid transport. Cell Rep. 2019;26:518–e5286.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chicco AJ, Sparagna GC. Role of cardiolipin alterations in mitochondrial dysfunction and disease. Am J Physiology-Cell Physiol. 2007;292:C33–44.

Article  CAS  Google Scholar 

Paradies G, Paradies V, Ruggiero FM, Petrosillo G. Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects. Cells. 2019;8:728.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dimitrijevs P, Arsenyan P. Cardiolipin in the spotlight: quantitative analysis and fluorescence-based competitive binding assay. Sens Actuators B. 2021;346:130537.

Article  CAS  Google Scholar 

Peyta L, Jarnouen K, Pinault M, Guimaraes C, Pais De Barros J-P, Chevalier S, et al. Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells. Biochim Et Biophys Acta (BBA) - Bioenergetics. 2016;1857:443–53.

Article  CAS  PubMed  Google Scholar 

Zhang J, Yu W, Ryu SW, Lin J, Buentello G, Tibshirani R, et al. Cardiolipins are biomarkers of mitochondria-rich thyroid oncocytic tumors. Cancer Res. 2016;76:6588–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN. Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. J Lipid Res. 2008;49:2545–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong H, Xiao M, Zarkovic K, Zhu M, Sa R, Lu J, et al. Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: a novel link between oxidative stress and cancer. Free Radic Biol Med. 2017;102:67–76.

Article  CAS  PubMed  Google Scholar 

San-Millan I, Sparagna GC, Chapman HL, Warkins VL, Chatfield KC, Shuff SR, et al. Chronic lactate exposure decreases mitochondrial function by inhibition of fatty acid uptake and cardiolipin alterations in neonatal rat cardiomyocytes. Front Nutr. 2022;9:809485.

Article  PubMed  PubMed Central  Google Scholar 

Chang W-H, Ting H-C, Chen W-W, Chan J-F, Hsu Y-HH. Omega-3 and omega-6 fatty acid differentially impact cardiolipin remodeling in activated macrophage. Lipids Health Dis. 2018;17:201.

Article  PubMed  PubMed Central  Google Scholar 

Oemer G, Edenhofer M-L, Wohlfarter Y, Lackner K, Leman G, Koch J, et al. Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in hela cells. J Lipid Res. 2021;62:100111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan Y-Y, Vaz FM, Chapkin RS. Dietary fat and fiber interactively modulate apoptosis and mitochondrial bioenergetic profiles in mouse colon in a site-specific manner. Eur J Cancer Prev. 2017;26:301–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angelini R, Vitale R, Patil VA, Cocco T, Ludwig B, Greenberg ML, et al. Lipidomics of intact mitochondria by MALDI-TOF/MS. J Lipid Res. 2012;53:1417–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angelini R, Lobasso S, Gorgoglione R, Bowron A, Steward CG, Corcelli A. Cardiolipin fingerprinting of leukocytes by MALDI-TOF/MS as a screening tool for Barth syndrome. J Lipid Res. 2015;56:1787–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arendowski A, Sibińska E, Miśta W, Fijałkowski P, Złoch M, Gabryś D, et al. Study of sample preparation influence on bacterial lipids profile in matrix-assisted laser desorption/ionization time‐of‐flight mass spectrometry. Lipids. 2024;59:13–26.

Article  CAS  PubMed  Google Scholar 

Tatsuta T. Quantitative analysis of glycerophospholipids in mitochondria by mass spectrometry. In: Mokranjac D, Perocchi F, editors. Mitochondria. New York, NY: Springer New York; 2017 [cited 2024 Nov 1]. pp. 79–103. Available from: http://link.springer.com/https://doi.org/10.1007/978-1-4939-6824-4_7

Han X, Gross RW. Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev. 2005;24:367–412.

Article  CAS  PubMed  Google Scholar 

Schlame M, Blais S, Edelman-Novemsky I, Xu Y, Montecillo F, Phoon CKL, et al. Comparison of cardiolipins from drosophila strains with mutations in putative remodeling enzymes. Chem Phys Lipids. 2012;165:512–9.

Article  CAS  PubMed  Google Scholar 

Yang H, Jackson SN, Woods AS, Goodlett DR, Ernst RK, Scott AJ. Streamlined analysis of cardiolipins in prokaryotic and eukaryotic samples using a Norharmane matrix by MALDI-MSI. J Am Soc Mass Spectrom. 2020;31:2495–502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–75.

Article  CAS  PubMed  Google Scholar 

Srere PA. [1] Citrate synthase. Methods in enzymology. Elsevier; 1969 [cited 2024 Nov 1]. pp. 3–11. Available from: https://linkinghub.elsevier.com/retrieve/pii/0076687969130050

Larsen S, Nielsen J, Hansen CN, Nielsen LB, Wibrand F, Stride N, et al. Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol. 2012;590:3349–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang J, Jiang Y, Zhang Y-G, Zhang T, Li J-H, Huang D-L, et al. The effects of hypoxia on mitochondrial function and metabolism in gastric cancer cells. Transl Cancer Res TCR. 2021;10:817–26.

Article