Antar SA, Ashour NA, Marawan ME, Al-Karmalawy AA (2023) Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation. Int J Mol Sci 24:4004

Bamias G, Pizarro TT, Cominelli F (2022) Immunological regulation of intestinal fibrosis in inflammatory bowel disease. Inflamm Bowel Dis 28:337–349

Article  PubMed  Google Scholar 

Chan WPW, Mourad F, Leong RW (2018) Crohn’s disease associated strictures. J Gastroenterol Hepatol 33:998–1008

Article  PubMed  Google Scholar 

Chen J, Wang X, Xia T, Bi Y, Liu B, Fu J, Zhu R (2021) Molecular mechanisms and therapeutic implications of dihydromyricetin in liver disease. Biomed Pharmacother. 142:111927

Article  PubMed  Google Scholar 

Chen L, Shi M, Lv C, Song Y, Wu Y, Liu S, Zheng Z, Lu X, Qin S (2021) Dihydromyricetin acts as a potential redox balance mediator in cancer chemoprevention. Mediators Inflamm 2021:6692579

Article  PubMed  PubMed Central  Google Scholar 

Crespi M, Dulbecco P, De Ceglie A, Conio M (2020) Strictures in Crohn’s disease: from pathophysiology to treatment. Dig Dis Sci 65:1904–1916

Article  PubMed  Google Scholar 

Cushing K, Higgins PDR (2021) Management of Crohn disease: a review. JAMA 325:69–80

Article  PubMed  PubMed Central  Google Scholar 

D’Haens G, Rieder F, Feagan BG, Higgins PDR, Panés J, Maaser C, Rogler G, Löwenberg M, van der Voort R, Pinzani M et al (2022) Challenges in the pathophysiology, diagnosis, and management of intestinal fibrosis in inflammatory bowel disease. Gastroenterology 162:26–31

Article  PubMed  Google Scholar 

Dong S, Zhu M, Wang K, Zhao X, Hu L, Jing W, Lu H, Wang S (2021) Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism. Pharmacol Res. 171:105767

Article  PubMed  Google Scholar 

Granato M, Rizzello C, Gilardini Montani MS, Cuomo L, Vitillo M, Santarelli R, Gonnella R, D’Orazi G, Faggioni A, Cirone M (2017) Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways. J Nutr Biochem 41:124–136

Article  PubMed  Google Scholar 

Guo L, Zhang H, Yan X (2019) Protective effect of dihydromyricetin revents fatty liver through nuclear factor-κB/p53/B-cell lymphoma 2-associated X protein signaling pathways in a rat model. Mol Med Rep 19:1638–1644

PubMed  Google Scholar 

Guo L, Tan K, Luo Q, Bai X (2020) Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy. Bosn J Basic Med Sci 20:372–380

PubMed  PubMed Central  Google Scholar 

Hayashi Y, Nakase H (2022) The molecular mechanisms of intestinal inflammation and fibrosis in Crohn’s disease. Front Physiol. 13:845078

Article  PubMed  PubMed Central  Google Scholar 

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK et al (2021) Autophagy in major human diseases. EMBO J. 40:e108863

Article  PubMed  PubMed Central  Google Scholar 

Li Q, Cui Y, Xu B, Wang Y, Lv F, Li Z, Li H, Chen X, Peng X, Chen Y et al (2021) Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner. Pharmacol Res. 170:105694

Article  PubMed  Google Scholar 

Liu MW, Su MX, Tang DY, Hao L, Xun XH, Huang YQ (2019) Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression. BMC Pulm Med. 19:35

Article  PubMed  PubMed Central  Google Scholar 

Liu M, Guo H, Li Z, Zhang C, Zhang X, Cui Q, Tian J (2020) Molecular level insight into the benefit of myricetin and dihydromyricetin uptake in patients with Alzheimer’s diseases. Front Aging Neurosci. 12:601603

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Lin H, Cao M, Lin T, Lin A, Xu W, Wang H, He J, Li Y, Tang H et al (2023) Shifts and importance of viable bacteria in treatment of DSS-induced ulcerative colitis mice with FMT. Front Cell Infect Microbiol. 13:1124256

Article  PubMed  PubMed Central  Google Scholar 

Lucantoni F, Martínez-Cerezuela A, Gruevska A, Moragrega ÁB, Víctor VM, Esplugues JV, Blas-García A, Apostolova N (2021) Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet? J Pathol 254:216–228

Article  PubMed  Google Scholar 

Ni T, Lin N, Lu W, Sun Z, Lin H, Chi J, Guo H (2020) Dihydromyricetin prevents diabetic cardiomyopathy via miR-34a suppression by activating autophagy. Cardiovasc Drugs Ther 34:291–301

Article  PubMed  Google Scholar 

Pakshir P, Noskovicova N, Lodyga M, Son DO, Schuster R, Goodwin A, Karvonen H, Hinz B (2020) The myofibroblast at a glance. J Cell Sci 133:jcs227900

Rezq S, Hassan R, Mahmoud MF (2021) Rimonabant ameliorates hepatic ischemia/reperfusion injury in rats: involvement of autophagy via modulating ERK- and PI3K/AKT-mTOR pathways. Int Immunopharmacol. 100:108140

Article  PubMed  Google Scholar 

Richter FC, Friedrich M, Kampschulte N, Piletic K, Alsaleh G, Zummach R, Hecker J, Pohin M, Ilott N, Guschina I et al (2023) Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10. EMBO J. 42:e112202

Article  PubMed  PubMed Central  Google Scholar 

Saha K, Subramenium Ganapathy A, Wang A, Michael Morris N, Suchanec E, Ding W, Yochum G, Koltun W, Nighot M, Ma T et al (2023) Autophagy reduces the degradation and promotes membrane localization of occludin to enhance the intestinal epithelial tight junction barrier against paracellular macromolecule flux. J Crohns Colitis 17:433–449

Article  PubMed  Google Scholar 

Shapiro JM, Subedi S, LeLeiko NS (2016) Inflammatory bowel disease. Pediatr Rev 37:337–347

Article  PubMed  Google Scholar 

Sleiman J, El Ouali S, Qazi T, Cohen B, Steele SR, Baker ME, Rieder F (2021) Prevention and treatment of stricturing Crohn’s disease - perspectives and challenges. Expert Rev Gastroenterol Hepatol 15:401–411

Article  PubMed  Google Scholar 

Song Q, Liu L, Yu J, Zhang J, Xu M, Sun L, Luo H, Feng Z, Meng G (2017) Dihydromyricetin attenuated Ang II induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress. Eur J Pharmacol 807:159–167

Article  PubMed  Google Scholar 

Su HY, Gupta V, Day AS, Gearry RB (2016) Rising incidence of inflammatory bowel disease in Canterbury. New Zealand Inflamm Bowel Dis 22:2238–2244

Article  PubMed  Google Scholar 

Sun Y, Liu S, Yang S, Chen C, Yang Y, Lin M, Liu C, Wang W, Zhou X, Ai Q et al (2021) Mechanism of dihydromyricetin on inflammatory diseases. Front Pharmacol. 12:794563

Article  PubMed  Google Scholar 

Vítek L, Tiribelli C (2020) Bilirubin, intestinal integrity, the microbiome, and inflammation. N Engl J Med 383:684–686

Article  PubMed  Google Scholar 

Wang J, Lin S, Brown JM, van Wagoner D, Fiocchi C, Rieder F (2021) Novel mechanisms and clinical trial endpoints in intestinal fibrosis. Immunol Rev 302:211–227

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Hu H, Hu B, Xia H, Cheng X, Zheng J, Zhang Z, Liu H (2023a) Dihydromyricetin inhibits hepatitis B virus replication by activating NF-κB, MAPKs, and autophagy in HepG2.2.15 cells. Mol Biol Rep 50:1403–1414

Article  PubMed  Google Scholar 

Wang Z, Cao Z, Yue Z, Yang Z (2023) Research progress of dihydromyricetin in the treatment of diabetes mellitus. Front Endocrinol. 14:1216907

Article  Google Scholar 

Wu X, Lin X, Tan J, Liu Z, He J, Hu F, Wang Y, Chen M, Liu F, Mao R (2023) Cellular and molecular mechanisms of intestinal fibrosis. Gut and Liver 17:360–374

Article  PubMed  PubMed Central  Google Scholar 

Xia Y, Lu Y, Qian S, Zhang J, Gao Y, Wei Y, Heng W (2023) An efficient cocrystallization strategy for separation of dihydromyricetin from vine tea and enhanced its antibacterial activity for food preserving application. Food Chem. 426:136525

Article  PubMed  Google Scholar 

Xiao T, Wei Y, Cui M, Li X, Ruan H, Zhang L, Bao J, Ren S, Gao D, Wang M et al (2021) Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis. Phytomedicine. 91:153704

Article  PubMed  PubMed Central  Google Scholar 

Xiu AY, Ding Q, Li Z, Zhang CQ (2021) Doxazosin attenuates liver fibrosis by inhibiting autophagy in hepatic stellate cells via activation of the PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther 15:3643–3659

Article  PubMed  PubMed Central  Google Scholar 

Yang M, Zhang Q, Taha R, Abdelmotalab MI, Wen Q, Yuan Y, Zhao Y, Li Q, Liao C, Huang X et al (2022) Polysaccharide from Atractylodes macrocephala Koidz. ameliorates DSS-induced colitis in mice by regulating the Th17/Treg cell balance. Front Immunol. 13:1021695

Article  PubMed  PubMed Central  Google Scholar 

Zeng C, Liu X, Xiong D, Zou K, Bai T (2022) Resolvin D1 prevents epithelial-to-mesenchymal transition and reduces collagen deposition by stimulating autophagy in intestinal fibrosis. Dig Dis Sci 67:4749–4759

Article  PubMed  Google Scholar 

Zhang Q, Zhao Y, Zhang M, Zhang Y, Ji H, Shen L (2021) Recent advances in research on vine tea, a potential and functional herbal tea with dihydromyricetin and myricetin as major bioactive compounds. J Pharm Anal 11:555–563

Article  PubMed  Google Scholar 

Zhou J, Jiang YY, Chen H, Wu YC, Zhang L (2020) Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway. Cell Prolif. 53:e12739