Dexpanthenol protects against nicotine-induced kidney injury by reducing oxidative stress and apoptosis through activation of the AKT/Nrf2/HO-1 pathway

Abdel-Rahman Mohamed A, El-Kholy SS, Dahran N, El Bohy KM, Moustafa GG, Saber TM, Metwally MMM, Gaber RA, Alqahtani LS, Mostafa-Hedeab G, El-Shetry ES (2022) Scrutinizing pathways of nicotine effect on renal Alpha-7 nicotinic acetylcholine receptor and Mitogen-activated protein kinase (MAPK) expression in Ehrlich ascites carcinoma-bearing mice: Role of Chlorella vulgaris. Gene 837:146697

Article  PubMed  CAS  Google Scholar 

Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121–126

Article  PubMed  CAS  Google Scholar 

Altinoz E, Oner Z, Elbe H, Uremis N, Uremis M (2022) Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress. Drug Chem Toxicol 45:2024–2030

Article  PubMed  CAS  Google Scholar 

Arany I, Reed DK, Grifoni SC, Chandrashekar K, Booz GW, Juncos LA (2012) A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury. Am J Physiol Renal Physiol 302:F722-729

Article  PubMed  CAS  Google Scholar 

Buccafusco JJ, Beach JW, Terry AV Jr (2009) Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. J Pharmacol Exp Ther 328:364–370

Article  PubMed  CAS  Google Scholar 

Burki TK (2021) WHO releases latest report on the global tobacco epidemic. Lancet Oncol 22:1217

Article  PubMed  Google Scholar 

Depeint F, Bruce WR, Shangari N, Mehta R, O’Brien PJ (2006) Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact 163:94–112

Article  PubMed  CAS  Google Scholar 

Ebner F, Heller A, Rippke F, Tausch I (2002) Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 3:427–433

Article  PubMed  Google Scholar 

Eddy AA (2000) Molecular basis of renal fibrosis. Pediatr Nephrol 15:290–301

Article  PubMed  CAS  Google Scholar 

Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77

Article  PubMed  CAS  Google Scholar 

Girolami F, Candellone A, Jarriyawattanachaikul W, Meineri G, Nebbia C, Badino P (2021) Protective effect of natural antioxidant compounds on methimazole induced oxidative stress in a feline kidney epithelial cell line (CRFK). Vet Sci 8(10):220

Article  PubMed  PubMed Central  Google Scholar 

Gounden V, Bhatt H, Jialal I (2023) Renal function tests. StatPearls, Treasure Island (FL)

Google Scholar 

Guo L, Li L, Wang W, Pan Z, Zhou Q, Wu Z (2012) Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1alpha expression in human non-small cell lung cancer cells. Biochim Biophys Acta 1822:852–861

Article  PubMed  CAS  Google Scholar 

Heeschen C, Jang JJ, Weis M, Pathak A, Kaji S, Hu RS, Tsao PS, Johnson FL, Cooke JP (2001) Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 7:833–839

Article  PubMed  CAS  Google Scholar 

Jaimes EA, Tian RX, Raij L (2007) Nicotine: the link between cigarette smoking and the progression of renal injury? Am J Physiol Heart Circ Physiol 292:H76-82

Article  PubMed  CAS  Google Scholar 

Jain G, Jaimes EA (2013) Nicotine signaling and progression of chronic kidney disease in smokers. Biochem Pharmacol 86:1215–1223

Article  PubMed  CAS  Google Scholar 

Jalili C, Salahshoor MR, Moradi MT, Ahookhash M, Taghadosi M, Sohrabi M (2017) Expression changes of apoptotic genes in tissues from mice exposed to nicotine. Asian Pac J Cancer Prev 18:239–244

PubMed  PubMed Central  Google Scholar 

Kim HJ, Park KK, Chung WY, Lee SK, Kim KR (2017) Protective effect of white-fleshed peach (Prunus persica (L.) Batsch) on chronic nicotine-induced toxicity. J Cancer Prev 22:22–32

Article  PubMed  PubMed Central  Google Scholar 

Kolli AR, Kuczaj AK, Martin F, Hayes AW, Peitsch MC, Hoeng J (2019) Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond. Crit Rev Toxicol 49:725–741

Article  PubMed  CAS  Google Scholar 

Kurt AH, Bozkus F, Uremis N, Uremis MM (2016) The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells. Ren Fail 38:686–692

Article  PubMed  CAS  Google Scholar 

Lan X, Lederman R, Eng JM, Shoshtari SS, Saleem MA, Malhotra A, Singhal PC (2016) Nicotine induces podocyte apoptosis through increasing oxidative stress. PLoS ONE 11:e0167071

Article  PubMed  PubMed Central  Google Scholar 

Loffredo L, Zicari AM, Occasi F, Perri L, Carnevale R, Angelico F, Del Ben M, Martino F, Nocella C, De Castro G, Cammisotto V, Battaglia S, Duse M, Violi F (2018) Role of NADPH oxidase-2 and oxidative stress in children exposed to passive smoking. Thorax 73:986–988

Article  PubMed  Google Scholar 

Ma Q, He X (2012) Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev 64:1055–1081

Article  PubMed  CAS  Google Scholar 

Malinska D, Wieckowski MR, Michalska B, Drabik K, Prill M, Patalas-Krawczyk P, Walczak J, Szymanski J, Mathis C, Van der Toorn M, Luettich K, Hoeng J, Peitsch MC, Duszynski J, Szczepanowska J (2019) Mitochondria as a possible target for nicotine action. J Bioenerg Biomembr 51:259–276

Article  PubMed  PubMed Central  CAS  Google Scholar 

Moiseenok AG, Komar VI, Khomich TI, Kanunnikova NP, Slyshenkov VS (2000) Pantothenic acid in maintaining thiol and immune homeostasis. BioFactors 11:53–55

Article  PubMed  CAS  Google Scholar 

Napierala M, Olszewski J, Miechowicz I, Jablecka A, Czarnywojtek A, Malinger S, Florek E (2019) The influence of tobacco smoke exposure on selected markers of oxidative stress, kidneys and liver function in the serum of rats with streptozotocin-induced diabetes. Pharmacol Rep 71:1293–1298

Article  PubMed  CAS  Google Scholar 

Newman MB, Arendash GW, Shytle RD, Bickford PC, Tighe T, Sanberg PR (2002) Nicotine’s oxidative and antioxidant properties in CNS. Life Sci 71:2807–2820

Article  PubMed  CAS  Google Scholar 

Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358

Article  PubMed  CAS  Google Scholar 

Orth SR (2000) Smoking–a risk factor for progression of renal disease. Kidney Blood Press Res 23:202–204

PubMed  CAS  Google Scholar 

Ortiz A, Lorz C, Justo P, Catalan MP, Egido J (2001) Contribution of apoptotic cell death to renal injury. J Cell Mol Med 5:18–32

Article  PubMed  PubMed Central  CAS  Google Scholar 

Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158–169

PubMed  CAS  Google Scholar 

Proksch E, de Bony R, Trapp S, Boudon S (2017) Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat 28:766–773

Article  PubMed  CAS  Google Scholar 

Redza-Dutordoir M, Averill-Bates DA (2016) Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta 1863:2977–2992

Article  PubMed  CAS  Google Scholar 

Saha P, Durugkar S, Jain S, Shantanu PA, Panda SR, Jala A, Gokhale S, Sharma P, Naidu VGM (2022) Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition by modulating the SIRT1/Nrf2 Axis. Int J Mol Sci 23(23):14722

Article  PubMed  PubMed Central  CAS  Google Scholar 

Saito H (2013) Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases. Biochem Pharmacol 85:865–872

Article  PubMed  CAS  Google Scholar 

Scharf P, Rizzetto F, Xavier LF, Farsky SHP (2022) Xenobiotics delivered by electronic nicotine delivery systems: potential cellular and molecular mechanisms on the pathogenesis of chronic kidney disease. Int J Mol Sci 23(18):10293

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sekine T, Hirata T, Mine T, Fukano Y (2016) Activation of transcription factors in human bronchial epithelial cells exposed to aqueous extracts of mainstream cigarette smoke in vitro. Toxicol Mech Methods 26:22–31

Article  PubMed  CAS  Google S

留言 (0)

沒有登入
gif