The SWI/SNF complex remodels chromatin across the mammalian genome, and loss of SWI/SNF function plays a large part in cancer development. The mechanisms by which altered SWI/SNF function affects its targets have remained unclear. In a recent paper in Cell, Martin et al. characterize the epigenomic and transcriptomic effects of SWI/SNF inhibition across time to show that, at some targets, SWI/SNF function is compensated for by the EP400/TIP60 chromatin remodeller complex.