Diagnosis of Adenoid Cystic Carcinoma with Striking Tubular Hypereosinophilia by MYB and EWSR1 Breakapart Fluorescence In Situ Hybridization

Bjørndal K, Krogdahl A, Therkildsen MH, Overgaard J, Johansen J, Kristensen CA et al (2011) Salivary gland carcinoma in Denmark 1990–2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA). Oral Oncol 47:677–82

Article  PubMed  Google Scholar 

Westergaard-Nielsen M, Godballe C, Eriksen JG, Larsen SR, Kiss K, Agander T et al (2021) Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome. Eur Arch Otorhinolaryngol 278:1179–1188

Article  PubMed  Google Scholar 

Seethala RR (2009) An update on grading of salivary gland carcinomas. Head Neck Pathol 3:69–77

Article  PubMed  PubMed Central  Google Scholar 

Inagaki H, Faquin WC, Stenman G et al (2022) Adenoid cystic carcinoma. In: WHO Classification of Tumours Editorial Board (eds) Head and neck tumours [Internet; beta version ahead of print]. WHO classification of tumours series, 5th edn, vol 9. International Agency for Research on Cancer, Lyon. https://tumourclassification.iarc.who.int/chapters/52

Jaso J, Malhotra R (2011) Adenoid cystic carcinoma. Arch Pathol Lab Med 135:511–515

Article  PubMed  Google Scholar 

Brayer KJ, Frerich CA, Kang H, Ness SA (2016) Recurrent fusions in MYB and MYBL1 define a common, transcription factor-driven oncogenic pathway in salivary gland adenoid cystic carcinoma. Cancer Discov 6:176–187

Article  CAS  PubMed  Google Scholar 

Mitani Y, Li J, Rao PH, Zhao YJ, Bell D, Lippman SM et al (2010) Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: incidence, variability, and clinicopathologic significance. Clin Cancer Res 16:4722–4731

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitani Y, Rao PH, Futreal PA, Roberts DB, Stephens PJ, Zhao YJ et al (2011) Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. Clin Cancer Res 17:7003–7014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mathew EP, Todorovic E, Truong T, Dickson BC, Enepekides D, Poon I et al (2022) Metatypical adenoid cystic carcinoma: a variant showing prominent squamous differentiation with a predilection for the sinonasal tract and skull base. Am J Surg Pathol 46:816–822

Article  PubMed  Google Scholar 

Weinreb I, Rooper LM, Dickson BC, Hahn E, Perez-Ordonez B, Smith SM et al (2023) Adenoid cystic carcinoma with striking tubular hypereosinophilia: a unique pattern associated with nonparotid location and both canonical and novel EWSR1::MYB and FUS::MYB fusions. Am J Surg Pathol 47:497–503

Article  PubMed  Google Scholar 

Antony VM, Kakkar A, Sikka K, Thakar A, Deo SVS, Bishop JA et al (2020) p16 immunoexpression in sinonasal and nasopharyngeal adenoid cystic carcinomas: a potential pitfall in ruling out HPV-related multiphenotypic sinonasal carcinoma. Histopathology 77:989–993

Article  PubMed  Google Scholar 

Kaur K, Kakkar A, Kumar A, Mallick S, Julka PK, Gupta D et al (2016) Integrating molecular subclassification of medulloblastomas into routine clinical practice: a simplified approach. Brain Pathol 26:334–343

Article  CAS  PubMed  Google Scholar 

Sebastiao APM, Xu B, Lozada JR et al (2020) Histologic spectrum of polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes. Mod Pathol 33:65–73

Article  CAS  PubMed  Google Scholar 

Higgins KE, Cipriani NA (2022) Practical immunohistochemistry in the classification of salivary gland neoplasms. Semin Diagn Pathol 39:17–28

Article  PubMed  Google Scholar 

Brill LB, Kanner WA, Fehr A, Andrén Y, Moskaluk CA, Löning T et al (2011) Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 24:1169–1176

Article  CAS  PubMed  Google Scholar 

Ueda K, Murase T, Kawakita D et al (2023) The landscape of MYB/MYBL1- and peri-MYB/MYBL1-associated rearrangements in adenoid cystic carcinoma. Mod Pathol 36:100274

Article  PubMed  Google Scholar 

Sams RN, Gnepp DR (2012) p63 expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinomas. Head Neck Pathol 7:64–68

Article  PubMed  PubMed Central  Google Scholar 

Nakayama T, Miyabe S, Okabe M, Sakuma H, Ijichi K, Hasegawa Y et al (2009) Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma. Mod Pathol 22:1575–1581

Article  CAS  PubMed  Google Scholar 

Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN (2010) A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol 34:1106–1121

Article  PubMed  Google Scholar 

De Cecio R, Cantile M, Fulciniti F, Botti G, Foschini MP, Losito NS (2017) Salivary epithelial-myoepithelial carcinoma: clinical, morphological and molecular features. Pathologica 109:1–8

PubMed  Google Scholar 

Urano M, Nakaguro M, Yamamoto Y et al (2019) Diagnostic Significance of HRAS mutations in epithelial–myoepithelial carcinomas exhibiting a broad histopathologic spectrum. Am J Surg Pathol 43:984–994

Article  PubMed  Google Scholar 

Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P et al (2021) Pleomorphic adenoma: the great mimicker of malignancy. Histopathology 79:279–290

Article  PubMed  Google Scholar 

Stenman G (2013) Fusion oncogenes in salivary gland tumors: molecular and clinical consequences. Head Neck Pathol 7:S12–S19

Article  PubMed  Google Scholar 

Patel TD, Vazquez A, Marchiano E, Park RC, Baredes S, Eloy JA (2015) Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases. Laryngoscope 125:1644–1649

Article  PubMed  Google Scholar 

Dahan LS, Giorgi R, Vergez S, Le Taillandier de Gabory L, Costes-Martineau V, Herman P et al (2021) Mucoepidermoid carcinoma of salivary glands: a French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 47:1376–83

Google Scholar 

Vázquez A, Patel TD, D’Aguillo CM, Abdou RY, Farver W, Baredes S et al (2015) Epithelial–myoepithelial carcinoma of the salivary glands: an analysis of 246 cases. Otolaryngol Head Neck Surg 153:569–574

Article  PubMed  Google Scholar 

Andreasen S, Therkildsen MH, Bjørndal K, Homøe P (2016) Pleomorphic adenoma of the parotid gland 1985–2010: a Danish nationwide study of incidence, recurrence rate, and malignant transformation. Head Neck 38(Suppl 1):E1364-1369

PubMed  Google Scholar 

Valstar MH, de Ridder M, van den Broek EC, Stuiver MM, van Dijk BC, van Velthuysen MLF et al (2017) Salivary gland pleomorphic adenoma in the Netherlands: a nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence. Oral Oncol. 66:93–99

Article  CAS  PubMed  Google Scholar 

Freiberger SN, Brada M, Fritz C et al (2021) SalvGlandDx—a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets. Neoplasia 23:473–487

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dickson BC, Swanson D (2019) Targeted RNA sequencing: a routine ancillary technique in the diagnosis of bone and soft tissue neoplasms. Genes Chromosomes Cancer 58:75–87

Article  CAS  PubMed  Google Scholar 

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