Hicks RM. The mammalian urinary bladder: an accommodating organ. Biol Rev Camb Philos Soc. 1975;50:215–46.
Article CAS PubMed Google Scholar
Truschel ST, Clayton DR, Beckel JM, Yabes JG, Yao Y, Wolf-Johnston A, et al. Age-related endolysosome dysfunction in the rat urothelium. PLoS One. 2018;13:e0198817.
Article PubMed PubMed Central Google Scholar
Jost SP, Potten CS. Urothelial proliferation in growing mice. Cell Tissue Kinet. 1986;19:155–60.
Wang J, Batourina E, Schneider K, Souza S, Swayne T, Liu C, et al. Polyploid superficial cells that maintain the urothelial barrier are produced via incomplete cytokinesis and endoreplication. Cell Rep. 2019;25:464–.e4.
Hudoklin S, Jezernik K, Neumüller J, Pavelka M, Romih R. Electron tomography of fusiform vesicles and their organization in urothelial cells. PLoS One. 2012;7:e32935.
Article CAS PubMed PubMed Central Google Scholar
Varley CL, Garthwaite MAE, Cross W, Hinley J, Trejdosiewicz LK, Southgate J. PPARgamma-regulated tight junction development during human urothelial cytodifferentiation. J Cell Physiol. 2006;208:407–17.
Article CAS PubMed PubMed Central Google Scholar
Harnden P, Eardley I, Joyce AD, Southgate J. Cytokeratin 20 as an objective marker of urothelial dysplasia. Br J Urol. 1996;78:870–5.
Article CAS PubMed Google Scholar
Gandhi D, Molotkov A, Batourina E, Schneider K, Dan H, Reiley M, et al. Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Dev Cell. 2013;26:469–82.
Article CAS PubMed PubMed Central Google Scholar
Papafotiou G, Paraskevopoulou V, Vasilaki E, Kanaki Z, Paschalidis N, Klinakis A. KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis. Nat Commun. 2016;7:11914.
Article CAS PubMed PubMed Central Google Scholar
Colopy SA, Bjorling DE, Mulligan WA, Bushman W. A population of progenitor cells in the basal and intermediate layers of the murine bladder urothelium contributes to urothelial development and regeneration. Dev Dyn. 2014;243:988–98.
Article CAS PubMed PubMed Central Google Scholar
Jost SP. Cell cycle of normal bladder urothelium in developing and adult mice. Virchows Arch B Cell Pathol. 1989;57:27–36.
Shin K, Lee J, Guo N, Kim J, Lim A, Qu L, et al. Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature. 2011;472:110–4.
Article CAS PubMed PubMed Central Google Scholar
Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, et al. Genomic subtypes of non-invasive bladder cancer with distinct metabolic profile and female gender bias in KDM6A mutation frequency. Cancer Cell. 2017;32:701–.e7.
Article CAS PubMed PubMed Central Google Scholar
Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, et al. Comprehensive molecular characterization of muscle-invasive bladder. Cancer Cell. 2017;171:540–.e25.
Wullweber A, Strick R, Lange F, Sikic D, Taubert H, Wach S, et al. Bladder tumor subtype commitment occurs in carcinoma in situ driven by key signaling pathways including ECM remodeling. Cancer Res. 2021;81:1552–66.
Article CAS PubMed Google Scholar
Bondaruk J, Jaksik R, Wang Z, Cogdell D, Lee S, Chen Y, et al. The origin of bladder cancer from mucosal field effects. iScience. 2022;25:104551.
Article PubMed PubMed Central Google Scholar
Majewski T, Yao H, Bondaruk J, Chung W, Lee S, Lee JG, et al. Whole-organ genomic characterization of mucosal field effects initiating bladder carcinogenesis. Cell Rep. 2019;26:2241–.e4.
Article CAS PubMed Google Scholar
Lawson ARJ, Abascal F, Coorens THH, Hooks Y, O’Neill L, Latimer C, et al. Extensive heterogeneity in somatic mutation and selection in the human bladder. Science. 2020;370:75–82.
Article CAS PubMed Google Scholar
López-Knowles E, Hernández S, Malats N, Kogevinas M, Lloreta J, Carrato A, et al. PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. Cancer Res. 2006;66:7401–4.
Taylor CF, Platt FM, Hurst CD, Thygesen HH, Knowles MA. Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes. Hum Mol Genet. 2014;23:1964–74.
Article CAS PubMed Google Scholar
Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhøi BP, et al. Comprehensive transcriptional analysis of early-stage urothelial carcinoma. Cancer Cell. 2016;30:27–42.
Article CAS PubMed Google Scholar
Hartmann A, Schlake G, Zaak D, Hungerhuber E, Hofstetter A, Hofstaedter F, et al. Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder. Cancer Res. 2002;62:809–18.
Kamoun A, de Reyniès A, Allory Y, Sjödahl G, Robertson AG, Seiler R, et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur Urol. 2020;77:420–33.
Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, et al. The human transcription factors. Cell. 2018;172:650–65.
Article CAS PubMed Google Scholar
Lee SH, Hu W, Matulay JT, Silva MV, Owczarek TB, Kim K, et al. Tumor evolution and drug response in patient-derived organoid models of bladder. Cancer Cell. 2018;173:515–.e17.
ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489:57–74.
Chen Z, Zhou L, Liu L, Hou Y, Xiong M, Yang Y, et al. Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma. Nat Commun. 2020;11:5077.
Article CAS PubMed PubMed Central Google Scholar
Evans RM, Mangelsdorf DJ. Nuclear receptors, RXR, and the big bang. Cell. 2014;157:255–66.
Article CAS PubMed PubMed Central Google Scholar
Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high-affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995;270:12953–6.
Article CAS PubMed Google Scholar
Mamtani R, Haynes K, Bilker WB, Vaughn DJ, Strom BL, Glanz K, et al. Association between longer therapy with thiazolidinediones and risk of bladder cancer: a cohort study. J Natl Cancer Inst. 2012;104:1411–21.
Article CAS PubMed PubMed Central Google Scholar
Varley CL, Stahlschmidt J, Lee W-C, Holder J, Diggle C, Selby PJ, et al. Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme. J Cell Sci. 2004;117:2029–36.
Article CAS PubMed Google Scholar
Santos CP, Lapi E, Martínez de Villarreal J, Álvaro-Espinosa L, Fernández-Barral A, Barbáchano A, et al. Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat Commun. 2019;10:4407.
Article PubMed PubMed Central Google Scholar
Suzuki K, Koyanagi-Aoi M, Uehara K, Hinata N, Fujisawa M, Aoi T. Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium. Sci Rep. 2019;9:10506.
Article PubMed PubMed Central Google Scholar
Weiss RM, Guo S, Shan A, Shi H, Romano R-A, Sinha S, et al. Brg1 determines urothelial cell fate during ureter development. J Am Soc Nephrol. 2013;24:618–26.
Article CAS PubMed PubMed Central Google Scholar
Liu C, Tate T, Batourina E, Truschel ST, Potter S, Adam M, et al. Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells. Nat Commun. 2019;10:4589.
Article PubMed PubMed Central Google Scholar
Liang F-X, Bosland MC, Huang H, Romih R, Baptiste S, Deng F-M, et al. Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement. J Cell Biol. 2005;171:835–44.
Article CAS PubMed PubMed Central Google Scholar
Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature. 2005;437:759–63.
Comments (0)