World Health Organization. Global action plan for the prevention and control of NCDs 2013–2020 // Global action plan for the prevention and control of noncommunicable diseases, 2013–2020. Geneva, Switzerland: World Health Organization; 2013.

Google Scholar 

Global Health Metrics. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1789–858. https://doi.org/10.1016/S0140-6736(18)32279-7.

Article  Google Scholar 

Savarese G, Becher PM, Lund LH, et al. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118:3272–87. https://doi.org/10.1093/cvr/cvac013.

Article  CAS  PubMed  Google Scholar 

Sue-Ling CB, Abel WM, Sue-Ling K. Coenzyme Q10 as adjunctive therapy for cardiovascular disease and hypertension: a systematic review. J Nutr. 2022;152:1666–74. https://doi.org/10.1093/jn/nxac079.

Article  PubMed  Google Scholar 

Linnane AW, Kios M, Vitetta L. Coenzyme Q(10)–its role as a prooxidant in the formation of superoxide anion/hydrogen peroxide and the regulation of the metabolome. Mitochondrion. 2007;7(Suppl):S51-61. https://doi.org/10.1016/j.mito.2007.03.005.

Article  CAS  PubMed  Google Scholar 

Mantle D, Dybring A. Bioavailability of Coenzyme Q10: an overview of the absorption process and subsequent metabolism. Antioxidants (Basel) 2020;9. https://doi.org/10.3390/antiox9050386.

Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20:591–8. https://doi.org/10.1080/07315724.2001.10719063.

Article  CAS  PubMed  Google Scholar 

Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007;37:31–7. https://doi.org/10.1007/s12033-007-0052-y.

Article  CAS  PubMed  Google Scholar 

Yubero-Serrano EM, Gonzalez-Guardia L, Rangel-Zuñiga O, et al. Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women. J Gerontol A Biol Sci Med Sci. 2012;67:3–10. https://doi.org/10.1093/gerona/glr167.

Article  CAS  PubMed  Google Scholar 

• Judy WV. The instability of the lipid-soluble antioxidant ubiquinol: part 3–misleading marketing claims. Integr Med (Encinitas). 2021;20:24–8. Important critical review outlining limitations of different studies concerning CoQH2.

PubMed  Google Scholar 

Judy WV. The instability of the lipid-soluble antioxidant ubiquinol: part 2-dog studies. Integr Med (Encinitas). 2021;20:26–30.

PubMed  Google Scholar 

Judy WV. The instability of the lipid-soluble antioxidant ubiquinol: part 1-lab studies. Integr Med (Encinitas). 2021;20:24–8.

PubMed  Google Scholar 

López-Lluch G, Del Pozo-Cruz J, Sánchez-Cuesta A, et al. Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition. 2019;57:133–40. https://doi.org/10.1016/j.nut.2018.05.020.

Article  CAS  PubMed  Google Scholar 

Raizner AE, Quiñones MA. Coenzyme Q10 for patients with cardiovascular disease: JACC focus seminar. J Am Coll Cardiol. 2021;77:609–19. https://doi.org/10.1016/j.jacc.2020.12.009.

Article  CAS  PubMed  Google Scholar 

Gutierrez-Mariscal FM, La Cruz-Ares S de, Torres-Peña JD et al. Coenzyme Q10 and cardiovascular diseases. Antioxidants (Basel) 2021;10. https://doi.org/10.3390/antiox10060906.

Judy WV, Stogsdill WW, Folkers K. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. Clin Investig. 1993;71:S155–61. https://doi.org/10.1007/BF00226859.

Article  CAS  PubMed  Google Scholar 

Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig. 1993;71:S134–6. https://doi.org/10.1007/BF00226854.

Article  CAS  PubMed  Google Scholar 

Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg. 1994;58:1427–32. https://doi.org/10.1016/0003-4975(94)91928-3.

Article  CAS  PubMed  Google Scholar 

Morisco C, Nappi A, Argenziano L, et al. Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: effects of short-term coenzyme Q10 treatment. Mol Aspects Med. 1994;15(Suppl):s155–63. https://doi.org/10.1016/0098-2997(94)90025-6.

Article  PubMed  Google Scholar 

Singh RB, Wander GS, Rastogi A, et al. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther. 1998;12:347–53. https://doi.org/10.1023/a:1007764616025.

Article  CAS  PubMed  Google Scholar 

Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol. 2004;27:295–9. https://doi.org/10.1002/clc.4960270512.

Article  PubMed  Google Scholar 

Chew GT, Watts GF, Davis TME, et al. Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction. Diabetes Care. 2008;31:1502–9. https://doi.org/10.2337/dc08-0118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makhija N, Sendasgupta C, Kiran U, et al. The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2008;22:832–9. https://doi.org/10.1053/j.jvca.2008.03.007.

Article  CAS  PubMed  Google Scholar 

Kuimov AD, Murzina TA. Coenzyme q10 in complex therapy of patients with ischemic heart disease. Kardiologiia. 2013;53:40–3.

CAS  PubMed  Google Scholar 

•• Mortensen SA, Rosenfeldt F, Kumar A, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014;2:641–9. https://doi.org/10.1016/j.jchf.2014.06.008. Proving that CoQ10 decreases mortality in patients with heart failure.

Article  PubMed  Google Scholar 

Aslanabadi N, Safaie N, Asgharzadeh Y, et al. The randomized clinical trial of coenzyme Q10 for the prevention of periprocedural myocardial injury following elective percutaneous coronary intervention. Cardiovasc Ther. 2016;34:254–60. https://doi.org/10.1111/1755-5922.12195.

Article  CAS  PubMed  Google Scholar 

Mortensen AL, Rosenfeldt F, Filipiak KJ. Effect of coenzyme Q10 in Europeans with chronic heart failure: a sub-group analysis of the Q-SYMBIO randomized double-blind trial. Cardiol J. 2019;26:147–56. https://doi.org/10.5603/CJ.a2019.0022.

Article  PubMed  PubMed Central  Google Scholar 

Sobirin MA, Herry Y, Sofia SN, et al. Effects of coenzyme Q10 supplementation on diastolic function in patients with heart failure with preserved ejection fraction. Drug Discov Ther. 2019;13:38–46. https://doi.org/10.5582/ddt.2019.01004.

Article  CAS  PubMed  Google Scholar 

Khan A, Johnson DK, Carlson S, et al. NT-Pro BNP predicts myocardial injury post-vascular surgery and is reduced with CoQ10: a randomized double-blind trial. Ann Vasc Surg. 2020;64:292–302. https://doi.org/10.1016/j.avsg.2019.09.017.

Article  PubMed  Google Scholar 

Kuklinski B, Weissenbacher E, Fähnrich A. Coenzyme Q10 and antioxidants in acute myocardial infarction. Mol Aspects Med. 1994;15(Suppl):s143–7. https://doi.org/10.1016/0098-2997(94)90023-x.

Article  PubMed  Google Scholar 

•• Alehagen U, Johansson P, Björnstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013;167:1860–6. https://doi.org/10.1016/j.ijcard.2012.04.156. Proving that CoQ10 decreases mortality in patients with heart failure after 5 years.

Article  PubMed  Google Scholar 

Alehagen U, Aaseth J, Johansson P. Reduced cardiovascular mortality 10 years after supplementation with selenium and Coenzyme Q10 for four years: follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly citizens. PLoS ONE. 2015;10:e0141641. https://doi.org/10.1371/journal.pone.0141641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alehagen U, Lindahl TL, Aaseth J, et al. Levels of sP-selectin and hs-CRP Decrease with dietary intervention with selenium and Coenzyme Q10 combined: a secondary analysis of a randomized clinical trial. PLoS ONE. 2015;10:e0137680. https://doi.org/10.1371/journal.pone.0137680.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alehagen U, Alexander J, Aaseth J. Supplementation with selenium and Coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. a secondary analysis of a randomised clinical trial. PLoS One 2016;11:e0157541. https://doi.org/10.1371/journal.pone.0157541.

Alehagen U, Aaseth J, Alexander J, et al. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: a validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLoS ONE. 2018;13:e0193120. https://doi.org/10.1371/journal.pone.0193120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alehagen U, Aaseth J, Lindahl TL, et al. (2021) Dietary supplementation with selenium and Coenzyme Q10 prevents increase in plasma D-dimer while lowering cardiovascular mortality in an elderly Swedish population. Nutrients 2021;13. https://doi.org/10.3390/nu13041344.

Opstad TB, Alexander J, Aaseth JO, et al. Selenium and Coenzyme Q10 intervention prevents telomere attrition, with association to reduced cardiovascular mortality-sub-study of a randomized clinical trial. Nutrients 2022;14. https://doi.org/10.3390/nu14163346.

Alehagen U, Johansson P, Svensson E, et al. Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden. Eur J Nutr. 2022;61:3135–48. https://doi.org/10.1007/s00394-022-02876-1.

Article  CAS  PubMed  PubMed Central