Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021;144:e368–454. https://doi.org/10.1161/CIR.0000000000001030.

Article  PubMed  Google Scholar 

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018;72:2231–2264.https://doi.org/10.1016/j.jacc.2018.08.1038.

Tamis-Holland JE, Jneid H, Reynolds HR, Agewall S, Brilakis ES, Brown TM, et al. Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association. Circulation. 2019;139:e891–908. https://doi.org/10.1161/CIR.0000000000000670.

Article  PubMed  Google Scholar 

Mehta LS, Beckie TM, DeVon HA, Grines CL, Krumholz HM, Johnson MN, et al. Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association. Circulation. 2016;133:916–47. https://doi.org/10.1161/CIR.0000000000000351.

Article  CAS  PubMed  Google Scholar 

Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145:e4–17. https://doi.org/10.1161/CIR.0000000000001039.

Article  PubMed  Google Scholar 

Surakka I, Wolford BN, Ritchie SC, Hornsby WE, Sutton NR, Elvenstad Gabrielsen M, et al. Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction. Circ Genom Precis Med. 2023;16:e003542. https://doi.org/10.1161/CIRCGEN.121.003542.

Article  CAS  PubMed  Google Scholar 

Hochman JS, Tamis JE, Thompson TD, Weaver WD, White HD, Van de Werf F, et al. Sex, clinical presentation, and outcome in patients with acute coronary syndromes. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes IIb Investigators. N Engl J Med. 1999;341:226–232. https://doi.org/10.1056/NEJM199907223410402.

Hasdai D, Porter A, Rosengren A, Behar S, Boyko V, Battler A. Effect of gender on outcomes of acute coronary syndromes. Am J Cardiol. 2003;91(1466–1469):A1466. https://doi.org/10.1016/s0002-9149(03)00400-4.

Article  Google Scholar 

Bellasi A, Raggi P, Merz CN, Shaw LJ. New insights into ischemic heart disease in women. Cleve Clin J Med. 2007;74:585–94. https://doi.org/10.3949/ccjm.74.8.585.

Article  PubMed  Google Scholar 

Cushman M, Shay CM, Howard VJ, Jimenez MC, Lewey J, McSweeney JC, et al. Ten-Year Differences in Women’s Awareness Related to Coronary Heart Disease: Results of the 2019 American Heart Association National Survey: A Special Report From the American Heart Association. Circulation. 2021;143:e239–48. https://doi.org/10.1161/CIR.0000000000000907.

Article  PubMed  Google Scholar 

Vogel B, Acevedo M, Appelman Y, Bairey Merz CN, Chieffo A, Figtree GA, et al. The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. Lancet. 2021;397:2385–438. https://doi.org/10.1016/S0140-6736(21)00684-X.

Article  PubMed  Google Scholar 

Pajjuru VS, Thandra A, Walters RW, Papudesi BN, Aboeata A, Vallabhajosyula S, et al. Sex disparities in in-hospital outcomes of left ventricular aneurysm complicating acute myocardial infarction: A United States nationwide analysis. American Heart Journal Plus: Cardiology Research and Practice. 2022;13:100104. https://doi.org/10.1016/j.ahjo.2022.100104.

Article  Google Scholar 

Blewer AL, McGovern SK, Schmicker RH, May S, Morrison LJ, Aufderheide TP, et al. Gender Disparities Among Adult Recipients of Bystander Cardiopulmonary Resuscitation in the Public. Circ Cardiovasc Qual Outcomes. 2018;11:e004710. https://doi.org/10.1161/CIRCOUTCOMES.118.004710.

Article  PubMed  PubMed Central  Google Scholar 

Worrall-Carter L, McEvedy S, Wilson A, Rahman MA. Gender Differences in Presentation, Coronary Intervention, and Outcomes of 28,985 Acute Coronary Syndrome Patients in Victoria. Australia Womens Health Issues. 2016;26:14–20. https://doi.org/10.1016/j.whi.2015.09.002.

Article  PubMed  Google Scholar 

Bugiardini R, Yan AT, Yan RT, Fitchett D, Langer A, Manfrini O, et al. Factors influencing underutilization of evidence-based therapies in women. Eur Heart J. 2011;32:1337–1344. https://doi.org/10.1093/eurheartj/ehr027.

Leon AS, Franklin BA, Costa F, Balady GJ, Berra KA, Stewart KJ, et al. Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2005;111:369–76. https://doi.org/10.1161/01.CIR.0000151788.08740.5C.

Article  PubMed  Google Scholar 

Fang J, Ayala C, Luncheon C, Ritchey M, Loustalot F. Use of Outpatient Cardiac Rehabilitation Among Heart Attack Survivors - 20 States and the District of Columbia, 2013 and Four States, 2015. MMWR Morb Mortal Wkly Rep. 2017;66:869–73. https://doi.org/10.15585/mmwr.mm6633a1.

Article  PubMed  PubMed Central  Google Scholar 

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics–2015 update: a report from the American Heart Association. Circulation. 2015;131:e29-322. https://doi.org/10.1161/CIR.0000000000000152.

Article  PubMed  Google Scholar 

Cenko E, Yoon J, Kedev S, Stankovic G, Vasiljevic Z, Krljanac G, et al. Sex Differences in Outcomes After STEMI: Effect Modification by Treatment Strategy and Age. JAMA Intern Med. 2018;178:632–9. https://doi.org/10.1001/jamainternmed.2018.0514.

Article  PubMed  PubMed Central  Google Scholar 

Sulaiman S, Kawsara A, Mohamed MO, Van Spall HGC, Sutton N, Holmes DR, et al. Treatment Effect of Percutaneous Coronary Intervention in Men Versus Women With ST-Segment-Elevation Myocardial Infarction. J Am Heart Assoc. 2021;10:e021638. https://doi.org/10.1161/JAHA.121.021638.

Article  PubMed  PubMed Central  Google Scholar 

Dehmer GJ, Grines CL, Bakaeen FG, Beasley DL, Beckie TM, Boyd J, et al. AHA/ACC Clinical Performance and Quality Measures for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures. Circ Cardiovasc Qual Outcomes. 2023;2023:e000121. https://doi.org/10.1161/HCQ.0000000000000121.

Article  Google Scholar 

Shibata T, Kawakami S, Noguchi T, Tanaka T, Asaumi Y, Kanaya T, et al. Prevalence, Clinical Features, and Prognosis of Acute Myocardial Infarction Attributable to Coronary Artery Embolism. Circulation. 2015;132:241–50. https://doi.org/10.1161/CIRCULATIONAHA.114.015134.

Article  CAS  PubMed  Google Scholar 

Raphael CE, Heit JA, Reeder GS, Bois MC, Maleszewski JJ, Tilbury RT, et al. Coronary Embolus: An Underappreciated Cause of Acute Coronary Syndromes. JACC Cardiovasc Interv. 2018;11:172–80. https://doi.org/10.1016/j.jcin.2017.08.057.

Article  PubMed  Google Scholar 

Tanis BC, van den Bosch MA, Kemmeren JM, Cats VM, Helmerhorst FM, Algra A, et al. Oral contraceptives and the risk of myocardial infarction. N Engl J Med. 2001;345:1787–93. https://doi.org/10.1056/NEJMoa003216.

Article  CAS  PubMed  Google Scholar 

Baldwin MK, Samuelson Bannow B, Rosovsky RP, Sokkary N, Srivaths LV. Hormonal therapies in females with blood disorders: thrombophilia, thrombosis, hemoglobinopathies, and anemias. Res Pract Thromb Haemost. 2023;7:100161. https://doi.org/10.1016/j.rpth.2023.100161.

Article  PubMed  PubMed Central  Google Scholar 

Teal S, Edelman A. Contraception Selection, Effectiveness, and Adverse Effects: A Review. JAMA. 2021;326:2507–18. https://doi.org/10.1001/jama.2021.21392.

Article  CAS  PubMed  Google Scholar 

Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, et al. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J. 2017;38:143–53. https://doi.org/10.1093/eurheartj/ehw149.

Article  PubMed  Google Scholar 

Rallidis LS, Xenogiannis I, Brilakis ES, Bhatt DL. Causes, Angiographic Characteristics, and Management of Premature Myocardial Infarction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022;79:2431–49. https://doi.org/10.1016/j.jacc.2022.04.015.

Article  PubMed  Google Scholar 

Lindahl B, Baron T, Erlinge D, Hadziosmanovic N, Nordenskjold A, Gard A, et al. Medical Therapy for Secondary Prevention and Long-Term Outcome in Patients With Myocardial Infarction With Nonobstructive Coronary Artery Disease. Circulation. 2017;135:1481–9. https://doi.org/10.1161/CIRCULATIONAHA.116.026336.

Article  PubMed  Google Scholar 

Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF. Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries. Circulation. 2015;131:861–70. https://doi.org/10.1161/CIRCULATIONAHA.114.011201.

Article  CAS  PubMed  Google Scholar 

Feldman L, Steg PG, Amsallem M, Puymirat E, Sorbets E, Elbaz M, et al. Editor’s Choice-Medically managed patients with non-ST-elevation acute myocardial infarction have heterogeneous outcomes, based on performance of angiography and extent of coronary artery disease. Eur Heart J Acute Cardiovasc Care. 2017;6:262–71. https://doi.org/10.1177/2048872615626354.

Article  PubMed  Google Scholar 

•• Reynolds HR, Maehara A, Kwong RY, Sedlak T, Saw J, Smilowitz NR, et al. Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women. Circulation. 2021;143:624–640. https://doi.org/10.1161/CIRCULATIONAHA.120.052008. Findings from this study suggest that multimodality imaging may identify of the cause of MINOCA is feasible and guide medical therapy for secondary prevention.

Kerkar AP, Juratli JH, Kumar AA, McLaren TA, Sutton NR. Best Practices for Physiologic Assessment of Coronary Stenosis. Curr Treat Options Cardiovasc Med. 2023;25:159–74. https://doi.org/10.1007/s11936-023-00984-7.

Article  Google Scholar 

Konst RE, Parker M, Bhatti L, Kaolawanich Y, Alenezi F, Elias-Smale SE, et al. Prognostic Value of Cardiac Magnetic Resonance Imaging in Patients With a Working Diagnosis of MINOCA-An Outcome Study With up to 10 Years of Follow-Up. Circ Cardiovasc Imaging. 2023;16: e014454. https://doi.org/10.1161/CIRCIMAGING.122.014454.

Article  PubMed  Google Scholar 

Saw J, Mancini GB, Humphries K, Fung A, Boone R, Starovoytov A, et al. Angiographic appearance of spontaneous coronary artery dissection with intramural hematoma proven on intracoronary imaging. Catheter Cardiovasc Interv. 2016;87:E54-61. https://doi.org/10.1002/ccd.26022.

Article  PubMed