Chen CY, Rao SS, Tan YJ, Luo MJ, Hu XK, Yin H, Huang J, Hu Y, Luo ZW, Liu ZZ, Wang ZX, Cao J, Liu YW, Li HM, Chen Y, Du W, Liu JH, Zhang Y, Chen TH, Liu HM, Wu B, Yue T, Wang YY, Xia K, Lei PF, Tang SY, Xie H (2019) Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG. Bone Res 7:18

Article  PubMed  PubMed Central  Google Scholar 

Srivastava RK, Dar HY, Mishra PK (2018) Immunoporosis: immunology of osteoporosis-role of T cells. Front Immunol 9:657

Article  PubMed  PubMed Central  Google Scholar 

Kanis JA, Pitt FA (1992) Epidemiology of osteoporosis. Bone 13(Suppl 1):S7-15

Article  PubMed  Google Scholar 

Huang D, Wang Y, Lv J, Yan Y, Hu Y, Liu C, Zhang F, Wang J, Hao D (2020) Proteomic profiling analysis of postmenopausal osteoporosis and osteopenia identifies potential proteins associated with low bone mineral density. PeerJ 8:e9009

Article  PubMed  PubMed Central  Google Scholar 

Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, Eckhardt B, Thicke B, Ruan M, Tweed AJ, McCready LK, Rizza RA, Matveyenko A, Kassem M, Andersen TL, Vella A, Drake MT, Clarke BL, Oursler MJ, Khosla S (2020) Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. Nat Commun 11:87

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao W, Liu Y, Cahill CM, Yang W, Rogers JT, Huang X (2009) The role of T cells in osteoporosis, an update. Int J Clin Exp Pathol 2:544–552

CAS  PubMed  PubMed Central  Google Scholar 

Laxman N, Rubin CJ, Mallmin H, Nilsson O, Pastinen T, Grundberg E, Kindmark A (2015) Global miRNA expression and correlation with mRNA levels in primary human bone cells. RNA 21:1433–1443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Wang C, Jin Y, Cai Y, Sun H, Liu M (2022) The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis. Sci Rep 12:9549

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W, Dang K, Huai Y, Qian A (2020) Osteoimmunology: the regulatory roles of T lymphocytes in osteoporosis. Front Endocrinol (Lausanne) 11:465

Article  PubMed  Google Scholar 

Dar HY, Singh A, Shukla P, Anupam R, Mondal RK, Mishra PK, Srivastava RK (2018) High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice. Sci Rep 8:2503

Article  PubMed  PubMed Central  Google Scholar 

Al-Barghouthi BM, Rosenow WT, Du KP, Heo J, Maynard R, Mesner L, Calabrese G, Nakasone A, Senwar B, Gerstenfeld L, Larner J, Ferguson V, Ackert-Bicknell C, Morgan E, Brautigan D, Farber CR (2022) Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations. Elife 11:e77285

Article  PubMed  PubMed Central  Google Scholar 

Consortium GT (2013) The genotype-tissue expression (GTEx) project. Nat Genet 45:580–585

Article  Google Scholar 

Ponten F, Schwenk JM, Asplund A, Edqvist PH (2011) The Human Protein Atlas as a proteomic resource for biomarker discovery. J Intern Med 270:428–446

Article  CAS  PubMed  Google Scholar 

Diboun I, Wani S, Ralston SH, Albagha OM (2021) Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status. Elife 10:e65715

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Gao Y, Xu C, Shen H, Tian Q, Deng HW (2018) A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research. Sci Rep 8:668

Article  PubMed  PubMed Central  Google Scholar 

Al-Barghouthi BM, Mesner LD, Calabrese GM, Brooks D, Tommasini SM, Bouxsein ML, Horowitz MC, Rosen CJ, Nguyen K, Haddox S, Farber EA, Onengut-Gumuscu S, Pomp D, Farber CR (2021) Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength. Nat Commun 12:3408

Article  CAS  PubMed  PubMed Central  Google Scholar 

MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, Junkins H, McMahon A, Milano A, Morales J, Pendlington ZM, Welter D, Burdett T, Hindorff L, Flicek P, Cunningham F, Parkinson H (2017) The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Res 45:D896–D901

Article  CAS  PubMed  Google Scholar 

Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N, International Mouse Phenotyping C, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet 49:1231–1238

Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L, Fu X, Liu S, Bo X, Yu G (2021) clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation (Camb) 2:100141

CAS  PubMed  Google Scholar 

Raudvere U, Kolberg L, Kuzmin I, Arak T, Adler P, Peterson H, Vilo J (2019) g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res 47:W191–W198

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wingender E, Dietze P, Karas H, Knuppel R (1996) TRANSFAC: a database on transcription factors and their DNA binding sites. Nucleic Acids Res 24:238–241

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian Y, Morris TJ, Webster AP, Yang Z, Beck S, Feber A, Teschendorff AE (2017) ChAMP: updated methylation analysis pipeline for Illumina BeadChips. Bioinformatics 33:3982–3984

Article  CAS  PubMed  PubMed Central  Google Scholar 

Law CW, Chen Y, Shi W, Smyth GK (2014) voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol 15:R29

Article  PubMed  PubMed Central  Google Scholar 

Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B, Liu XS (2020) TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res 48:W509–W514

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559

Article  PubMed  PubMed Central  Google Scholar 

Langfelder P, Luo R, Oldham MC, Horvath S (2011) Is my network module preserved and reproducible? PLoS Comput Biol 7:e1001057

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raouf A, Seth A (2000) Ets transcription factors and targets in osteogenesis. Oncogene 19:6455–6463

Article  CAS  PubMed  Google Scholar 

Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Muller R, Chai Y, Smith E, Bab I, Frenkel B (2009) Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS ONE 4:e5438

Article  PubMed  PubMed Central  Google Scholar 

Ebrahimi P, Luthman H, McGuigan FE, Akesson KE (2021) Epigenome-wide cross-tissue correlation of human bone and blood DNA methylation - can blood be used as a surrogate for bone? Epigenetics 16:92–105

Article  PubMed  Google Scholar 

Khosla S, Melton LJ 3rd, Riggs BL (1999) Osteoporosis: gender differences and similarities. Lupus 8:393–396

Article  CAS  PubMed  Google Scholar 

Karasik D, Ferrari SL (2008) Contribution of gender-specific genetic factors to osteoporosis risk. Ann Hum Genet 72:696–714

Article  CAS  PubMed  Google Scholar 

Merten M, Greiner JFW, Niemann T, Grosse Venhaus M, Kronenberg D, Stange R, Wahnert D, Kaltschmidt C, Vordemvenne T, Kaltschmidt B (2022) Human sex matters: Y-linked lysine demethylase 5D drives accelerated male craniofacial osteogenic differentiation. Cells 11:823

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minoia A, Dalle Carbonare L, Schwamborn JC, Bolognin S, Valenti MT (2022) Bone tissue and the nervous system: what do they have in common? Cells 12:51

Article  PubMed  PubMed Central  Google Scholar 

Wang C, Gu W, Sun B, Zhang Y, Ji Y, Xu X, Wen Y (2017) CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ. J Mol Histol 48:311–319

Article  CAS  PubMed  Google Scholar 

Lee SH, Kang MI, Ahn SH, Lim KH, Lee GE, Shin ES, Lee JE, Kim BJ, Cho EH, Kim SW, Kim TH, Kim HJ, Yoon KH, Lee WC, Kim GS, Koh JM, Kim SY (2014) Common and rare variants in the exons and regulatory regions of osteoporosis-related genes improve osteoporotic fracture risk prediction. J Clin Endocrinol Metab 99:E2400-2411

Article  CAS  PubMed