•• Bodilsen J, et al. Risk factors for brain abscess: a nationwide, population-based, nested case-control study. Clin Infect Dis. 2020;71(4):1040–6. A population-based study involving 1,384 brain abscess patients revealed major risk factors: neurosurgery (aOR 19.3), congenital heart disease (aOR 15.6), dental infections (aOR 4.61), and ear, nose, and throat infections (aOR 3.81). Among patients, significant associations with brain abscess occurrence included hematological cancer (aOR 8.77), immunomodulating treatments (aOR 5.71), and conditions like diabetes, alcohol abuse, and liver disease.

Article  PubMed  Google Scholar 

• Bodilsen J, et al. Clinical features and prognostic factors in adults with brain abscess. Brain. 2023;146(4):1637–47. A study of 485 cases highlighted the increasing incidence of brain abscesses in adults and identified key mortality risk factors, including brain abscess rupture and immunocompromise. The research suggests delaying antibiotics in select cases awaiting neurosurgery within 24 hours and found no increased mortality risk with corticosteroids for brain edema.

Article  PubMed  Google Scholar 

Cantiera M, Tattevin P, Sonneville R. Brain abscess in immunocompetent adult patients. Rev Neurol (Paris). 2019;175(7–8):469–74.

Article  CAS  PubMed  Google Scholar 

Mendes M, et al. Susceptibility of brain and skin to bacterial challenge. J Neurosurg. 1980;52(6):772–5.

Article  CAS  PubMed  Google Scholar 

•• Stebner A, et al. Molecular diagnosis of polymicrobial brain abscesses with 16S-rDNA-based next-generation sequencing. Clin Microbiol Infect. 2021;27(1):76–82. A study utilizing 16S-rRNA-based next-generation sequencing (NGS) to identify bacteria in intracranial abscesses and meningitis samples, aiming to overcome the limitations of culture-based methods and traditional molecular diagnostics in detecting the diverse bacterial causes. Using NGS, 86 bacterial taxa were identified in brain abscesses with Streptococcus intermedius and Fusobacterium nucleatum as the most common. The study underscores the often polymicrobial nature of these infections, detecting up to 16 different bacterial taxa in a single sample, and establishes the MiSeq platform’s effectiveness for metagenomic diagnostics of such severe infections.

Article  CAS  PubMed  Google Scholar 

Sonneville R, et al. An update on bacterial brain abscess in immunocompetent patients. Clin Microbiol Infect. 2017;23(9):614–20.

Article  CAS  PubMed  Google Scholar 

Brouwer MC, Tunkel AR, van de Beek D. Brain abscess. N Engl J Med. 2014;371(18):1758.

PubMed  Google Scholar 

Brouwer MC, van de Beek D. Epidemiology, diagnosis, and treatment of brain abscesses. Curr Opin Infect Dis. 2017;30(1):129–34.

Article  PubMed  Google Scholar 

•• Corsini Campioli C et al.  Bacterial brain abscess: an outline for diagnosis and management. Am J Med. 2021;134(10):1210–1217. A retrospective review of 247 adults presenting with pyogenic brain abscess between 2009–2020, assessing the diagnostic methods and treatment approaches. Most patients (93.1%) underwent diagnostic brain MRI, and a majority (83%) received combined medical and surgical treatments. Those treated medically only exhibited a higher mortality rate (21.4% vs 6%) and increased neurologic complications. The findings suggest the importance of a combined medical-surgical approach with extended antimicrobial therapy for better outcomes and reducing permanent neurologic deficits.

Corsini Campioli C et al. Clinical presentation, management, and outcomes of patients with brain abscess due to nocardia species. Open Forum Infect Dis. 2021;8(4):ofab067. 

Li X, Tronstad L, Olsen I. Brain abscesses caused by oral infection. Endod Dent Traumatol. 1999;15(3):95–101.

Article  CAS  PubMed  Google Scholar 

Fischbein CA, et al. Risk factors of brain abscess in patients with congenital heart disease. Am J Cardiol. 1974;34(1):97–102.

Article  CAS  PubMed  Google Scholar 

Thompson RL, Cattaneo SM, Barnes J. Recurrent brain abscess: manifestation of pulmonary arteriovenous fistula and hereditary hemorrhagic telangiectasia. Chest. 1977;72(5):654–5.

Article  CAS  PubMed  Google Scholar 

Lisboa ECC, et al. The connection between brain abscess and odontogenic infections: a systematic review. Arch Oral Biol. 2022;135: 105360.

Article  PubMed  Google Scholar 

Al Masalma M, et al. Metagenomic analysis of brain abscesses identifies specific bacterial associations. Clin Infect Dis. 2012;54(2):202–10.

Article  CAS  PubMed  Google Scholar 

Zhou W, Shao X, Jiang X. A clinical report of two cases of cryptogenic brain abscess and a relevant literature review. Front Neurosci. 2018;12:1054.

Article  PubMed  Google Scholar 

Jim KK, Brouwer MC, van der Ende A, van de Beek D. Cerebral abscesses in patients with bacterial meningitis. J Infect. 2012;64(2):236–8.

Article  PubMed  Google Scholar 

Nelson CA, Zunt JR. Tuberculosis of the central nervous system in immunocompromised patients: HIV infection and solid organ transplant recipients. Clin Infect Dis. 2011;53(9):915–26.

Article  PubMed  PubMed Central  Google Scholar 

Tan IL, et al. HIV-associated opportunistic infections of the CNS. Lancet Neurol. 2012;11(7):605–17.

Article  PubMed  Google Scholar 

Modi M, Mochan A, Modi G. Management of HIV-associated focal brain lesions in developing countries. QJM. 2004;97(7):413–21.

Article  CAS  PubMed  Google Scholar 

Mamelak AN, Obana WG, Flaherty JF, Rosenblum ML. Nocardial brain abscess: treatment strategies and factors influencing outcome. Neurosurgery. 1994;35(4):622–31.

Article  CAS  PubMed  Google Scholar 

Yetmar ZA, et al. Outcomes of nocardiosis and treatment of disseminated infection in solid organ transplant recipients. Transplantation. 2023;107(3):782–91.

Article  CAS  PubMed  Google Scholar 

Selby R, et al. Brain abscess in solid organ transplant recipients receiving cyclosporine-based immunosuppression. Arch Surg. 1997;132(3):304–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alagha R, et al. Volvariella volvacea brain abscess in an immunocompromised host-An emerging fungal pathogen in Asia. J Mycol Med. 2022;32(3):101272.

Article  PubMed  Google Scholar 

St John JA, et al. Burkholderia pseudomallei penetrates the brain via destruction of the olfactory and trigeminal nerves: implications for the pathogenesis of neurological melioidosis. MBio. 2014;5(2):e00025.

Article  PubMed  PubMed Central  Google Scholar 

Chadwick DR, Ang B, Sitoh YY, Lee CC. Cerebral melioidosis in Singapore: a review of five cases. Trans R Soc Trop Med Hyg. 2002;96(1):72–6.

Article  CAS  PubMed  Google Scholar 

Ibekwe TS, Nwaorgu OG. Classification and management challenges of otitis media in a resource-poor country. Niger J Clin Pract. 2011;14(3):262–9.

Article  CAS  PubMed  Google Scholar 

Wu JF, et al. Extracranial and intracranial complications of otitis media: 22-year clinical experience and analysis. Acta Otolaryngol. 2012;132(3):261–5.

Article  PubMed  Google Scholar 

Higuita NA, et al. U.S bound journey of migrant peoples InTransit across Dante’s inferno and purgatory in the Americas. Travel Med Infect Dis. 2022;47:102317.

Article  PubMed  Google Scholar 

Dwyer-Lindgren L, et al. Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017. Nature. 2019;570(7760):189–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Osborn MK, Steinberg JP. Subdural empyema and other suppurative complications of paranasal sinusitis. Lancet Infect Dis. 2007;7(1):62–7.

Article  PubMed  Google Scholar 

Kichenbrand C, et al. Brain abscesses and intracranial empyema due to dental pathogens: case series. Int J Surg Case Rep. 2020;69:35–8.

Article  PubMed  PubMed Central  Google Scholar 

Viswanatha B, Nsaeeruddin K. Conservative management of otogenic brain abscess with surgical management of attico antral ear disease: a review. Indian J Otolaryngol Head Neck Surg. 2012;64(2):113–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao F, et al. Brain abscess: clinical experience and analysis of prognostic factors. Surg Neurol. 2005;63(5):442–9 (discussion 449-50).

Article  PubMed  Google Scholar 

Taj S, et al. Infective endocarditis leading to intracranial abscess: a case report and literature review. Cureus. 2021;13(1):e12660.

PubMed  PubMed Central  Google Scholar 

Daoud H, Abugroun A, Olanipekun O, Garrison D. Infective endocarditis and brain abscess secondary to Aggregatibacter aphrophilus. IDCases. 2019;17:e00561.

Article  PubMed  PubMed Central  Google Scholar 

Wongwandee M, Linasmita P. Central nervous system melioidosis: a systematic review of individual participant data of case reports and case series. PLoS Negl Trop Dis. 2019;13(4):e0007320.

Article  PubMed  PubMed Central  Google Scholar 

Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–18.

Article  PubMed  PubMed Central  Google Scholar 

Russo TA and CM Marr. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev. 2019;32(3).

Wu C, Han S, Baydur A, Lindgren B. Klebsiella brain abscess in an immunocompetent patient: a case report. J Med Case Rep. 2021;15(1):44.

Article  PubMed  PubMed Central  Google Scholar 

Goralska K, Blaszkowska J, Dzikowiec M. Neuroinfections caused by fungi. Infection. 2018;46(4):443–59.

Article  PubMed  PubMed Central