*Department of Cardiovascular Medicine, People's Hospital of Wanning, Wanning, Hainan, China;

†Department of Science and Education, People's Hospital of Wanning, Wanning, Hainan, China; and

‡Department of General Practice, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.

Correspondence: Yipeng Ding, PhD, No. 19, Xiuhua Road, Xiuying District, Haikou 570311, Hainan, China (e-mail: [email protected]).

The author(s) report(s) no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jcvp.org).

Our study was approved by the Ethics Committee of the People's Hospital of Wanning, and the ethical documents is shown in the Supplemental Digital Content 1 (see https://links.lww.com/JCVP/A964). All procedures performed in studies involving human participants were in accordance with the ethical standards of the People's Hospital of Wanning and Helsinki's Declaration, and informed consent was obtained from all individual participants included in the study.

The original trial data including SNP genotyping data (see Supplemental Digital Content 2, https://links.lww.com/JCVP/A965) and peak diagram of SNP genotyping (see Supplemental Digital Content 3-11, https://links.lww.com/JCVP/A966, https://links.lww.com/JCVP/A967, https://links.lww.com/JCVP/A968, https://links.lww.com/JCVP/A969, https://links.lww.com/JCVP/A970, https://links.lww.com/JCVP/A971, https://links.lww.com/JCVP/A972, https://links.lww.com/JCVP/A973, https://links.lww.com/JCVP/A974) for this study is presented in the Supplemental data file.

Yongdong Li and Jiaqiang Zhang are co-first author.

Y. Li drafted the manuscript; J. Zhang performed the DNA extraction and genotyping; J. He performed the data analysis; X. Chen and X. Zhang was responsible for the sample collection and information recording; H. Wu revised the manuscript; Y. Ding conceived and supervised the study. All authors read and approved the final manuscript.