Department of Emergency, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Correspondence: Lei Wang, MD, Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China 450052 (e-mail: [email protected]).

Supported by Henan Province Science and Technology Research (Grant No. 192102310060).

The authors report no conflicts of interest.

The data used to support the findings of this study are available from the corresponding author upon request.

This study was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University (2020-KY-0928-005), and all patients gave informed consent and signed the informed consent form. All procedures of animal experiment were performed in accordance with the Guide for the Care and Use of Laboratory Animals published by the U.S. National Institutes of Health (NIH publication, eighth edition, 2011) and approved by the Committee on Animal Care and Use of the Ethical Committee of Zunyi Medical University.

L. Wang and Z. Wang conceptualized and designed the study and drafted the initial manuscript. L. Zhang, L. Cui, X. Yue, L. Huang, N. Liu, and M. Zhu collected the data and carried out the initial analyses. Z. Wang critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.