*Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China;

†Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China;

‡Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, Jining, Shandong, China;

§Department of Ultrasound, Affiliated Hospital of Jining Medical University, Jining, Shandong, China;

¶Deprartment of Cardiology, Jinxiang People's Hospital, Jining, Shandong, China;

║Clinical Medical College, Jining Medical University, Jining, Shandong, China; and

**Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Correspondence: Jinguo Zhang, PhD or Lijun Gan, PhD, Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, Jining 272000, Shandong, China (e-mail: [email protected] or [email protected]).

This study was supported by the Surface Project of National Natural Science Foundation of Shandong (ZR202112020064 to Jinguo Zhang), the Jining Key Research and Development Project (2020JKNS006 to L. Gan), and the Youth Project of the National Natural Science Foundation of China (82000269 to C. Shen).

The authors report no conflicts of interest.

This study was approved by the Ethics Committee of the Affiliated Hospital of Jining Medical University (Approval Document No. 2021C075).

J. Zhang, L. Gan, and Y. Cao conceived and designed this study. C. Shen, X. Chen, Y. Du, and Q. Wu performed the animal treatments. X. Xu participated in the echocardiographic examination. Y. Qin and R. Meng contributed to the ELISA and Western blotting experiments. L. Lin participated in the histological analysis. C. Shen, X. Chen, and Y. Cao contributed to generating the figures and drafting the manuscript. J. Zhang and L. Gan contributed to revising this manuscript. All the authors read and approved the manuscript.