Early growth response 2, a novel target of pelvic organ prolapse, is highly expressed in anterior vaginal wall tissues with pelvic organ prolapse

Barber MD (2016) Pelvic organ prolapse. BMJ 354:i3853. https://doi.org/10.1136/bmj.i3853

Article  PubMed  Google Scholar 

Barber MD, Maher C (2013) Epidemiology and outcome assessment of pelvic organ prolapse. Int Urogynecol J 24(11):1783–1790. https://doi.org/10.1007/s00192-013-2169-9

Article  PubMed  Google Scholar 

Beckmann AM, Wilce PA (1997) Egr transcription factors in the nervous system. Neurochem Int 31(4):477–510. https://doi.org/10.1016/s0197-0186(96)00136-2. (discussion 517-476)

Article  CAS  PubMed  Google Scholar 

Carow B, Rottenberg ME (2014) SOCS3, a major regulator of infection and inflammation. Front Immunol 5:58. https://doi.org/10.3389/fimmu.2014.00058

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, Yeh J (2011) Alterations in connective tissue metabolism in stress incontinence and prolapse. J Urol 186(5):1768–1772. https://doi.org/10.1016/j.juro.2011.06.054

Article  CAS  PubMed  Google Scholar 

Chen B, Wen Y, Yu X, Polan ML (2005) Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones? Am J Obstet Gynecol 192(5):1605–1613. https://doi.org/10.1016/j.ajog.2004.11.027

Article  CAS  PubMed  Google Scholar 

Chen M, Zeng J, Chen S, Li J, Wu H, Dong X, Lei Y, Zhi X, Yao L (2020) SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway. Aging (Albany NY) 12(11):10896–10911. https://doi.org/10.18632/aging.103303

Article  CAS  PubMed  Google Scholar 

Creemers LB, Jansen ID, Docherty AJ, Reynolds JJ, Beertsen W, Everts V (1998) Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue. Matrix Biol 17(1):35–46. https://doi.org/10.1016/s0945-053x(98)90123-8

Article  CAS  PubMed  Google Scholar 

De Landsheere L, Munaut C, Nusgens B, Maillard C, Rubod C, Nisolle M, Cosson M, Foidart JM (2013) Histology of the vaginal wall in women with pelvic organ prolapse: a literature review. Int Urogynecol J 24(12):2011–2020. https://doi.org/10.1007/s00192-013-2111-1

Article  PubMed  Google Scholar 

Dees C, Potter S, Zhang Y, Bergmann C, Zhou X, Luber M, Wohlfahrt T, Karouzakis E, Ramming A, Gelse K, Yoshimura A, Jaenisch R, Distler O, Schett G, Distler JH (2020) TGF-beta-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis. J Clin Invest 130(5):2347–2363. https://doi.org/10.1172/JCI122462

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du N, Kwon H, Li P, West EE, Oh J, Liao W, Yu Z, Ren M, Leonard WJ (2014) EGR2 is critical for peripheral naive T-cell differentiation and the T-cell response to influenza. Proc Natl Acad Sci USA 111(46):16484–16489. https://doi.org/10.1073/pnas.1417215111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elneil S (2009) Complex pelvic floor failure and associated problems. Best Pract Res Clin Gastroenterol 23(4):555–573. https://doi.org/10.1016/j.bpg.2009.04.011

Article  PubMed  Google Scholar 

Emmerson S, Mukherjee S, Melendez-Munoz J, Cousins F, Edwards SL, Karjalainen P, Ng M, Tan KS, Darzi S, Bhakoo K, Rosamilia A, Werkmeister JA, Gargett CE (2019) Composite mesh design for delivery of autologous mesenchymal stem cells influences mesh integration, exposure and biocompatibility in an ovine model of pelvic organ prolapse. Biomaterials 225:119495. https://doi.org/10.1016/j.biomaterials.2019.119495

Article  CAS  PubMed  Google Scholar 

Gabriel B, Denschlag D, Gobel H, Fittkow C, Werner M, Gitsch G, Watermann D (2005) Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct 16(6):475–479. https://doi.org/10.1007/s00192-005-1294-5

Article  PubMed  Google Scholar 

Hirakata S, Aoki H, Ohno-Urabe S, Nishihara M, Furusho A, Nishida N, Ito S, Hayashi M, Yasukawa H, Imaizumi T, Hiromatsu S, Tanaka H, Fukumoto Y (2020) Genetic deletion of socs3 in smooth muscle cells ameliorates aortic dissection in mice. JACC Basic Transl Sci 5(2):126–144. https://doi.org/10.1016/j.jacbts.2019.10.010

Article  PubMed  PubMed Central  Google Scholar 

Kerkhof MH, Hendriks L, Brolmann HA (2009) Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct 20(4):461–474. https://doi.org/10.1007/s00192-008-0737-1

Article  CAS  PubMed  Google Scholar 

Kim EJ, Chung N, Park SH, Lee KH, Kim SW, Kim JY, Bai SW, Jeon MJ (2013) Involvement of oxidative stress and mitochondrial apoptosis in the pathogenesis of pelvic organ prolapse. J Urol 189(2):588–594. https://doi.org/10.1016/j.juro.2012.09.041

Article  CAS  PubMed  Google Scholar 

Kisling A, Lust RM, Katwa LC (2019) What is the role of peptide fragments of collagen I and IV in health and disease? Life Sci 228:30–34. https://doi.org/10.1016/j.lfs.2019.04.042

Article  CAS  PubMed  Google Scholar 

Li S, Miao T, Sebastian M, Bhullar P, Ghaffari E, Liu M, Symonds AL, Wang P (2012) The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells. Immunity 37(4):685–696. https://doi.org/10.1016/j.immuni.2012.08.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Sun Z, Chen J, Zhang Y, Shi H, Zhu L (2020) Genetic polymorphisms in collagen-related genes are associated with pelvic organ prolapse. Menopause 27(2):223–229. https://doi.org/10.1097/GME.0000000000001448

Article  PubMed  PubMed Central  Google Scholar 

Li X, Liu R, Cui Y, Liang J, Bi Z, Li S, Miao Y, Zhang L, Li X, Zhou H, Yang C (2021) Protective effect of remdesivir against pulmonary fibrosis in mice. Front Pharmacol 12:692346. https://doi.org/10.3389/fphar.2021.692346

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Hu R, Wang H, Xu W (2022) Effect of SOCS3 on vocal fold fibroblast activation by regulating the JAK2/STAT3 signalling pathway. Tissue Cell 79:101965. https://doi.org/10.1016/j.tice.2022.101965

Article  CAS  PubMed  Google Scholar 

Maga G, Hubscher U (2003) Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 116(Pt 15):3051–3060. https://doi.org/10.1242/jcs.00653

Article  CAS  PubMed  Google Scholar 

Min J, Li B, Liu C, Guo W, Hong S, Tang J, Hong L (2017) Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts. Mol Med Rep 15(5):3278–3284. https://doi.org/10.3892/mmr.2017.6372

Article  CAS  PubMed  Google Scholar 

Moon YJ, Choi JR, Jeon MJ, Kim SK, Bai SW (2011) Alteration of elastin metabolism in women with pelvic organ prolapse. J Urol 185(5):1786–1792. https://doi.org/10.1016/j.juro.2010.12.040

Article  CAS  PubMed  Google Scholar 

Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D’Antonio M, Mirsky R, Jessen KR (2004) Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death. J Cell Biol 164(3):385–394. https://doi.org/10.1083/jcb.200307132

Article  CAS  PubMed  PubMed Central  Google Scholar 

Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6(2):99–104. https://doi.org/10.1038/sj.cdd.4400476

Article  CAS  PubMed  Google Scholar 

Reddy MA, Das S, Zhuo C, Jin W, Wang M, Lanting L, Natarajan R (2016) Regulation of vascular smooth muscle cell dysfunction under diabetic conditions by miR-504. Arterioscler Thromb Vasc Biol 36(5):864–873. https://doi.org/10.1161/ATVBAHA.115.306770

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sampson N, Berger P, Zenzmaier C (2014) Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease. Biomed Res Int 2014:131737. https://doi.org/10.1155/2014/131737

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao H, Shi P, Zhao XD, Xuan HY, Gong WH, Ding XS (2021) DNMT1 deregulation of SOCS3 axis drives cardiac fibroblast activation in diabetic cardiac fibrosis. J Cell Physiol 236(5):3481–3494. https://doi.org/10.1002/jcp.30078

Article  CAS  PubMed  Google Scholar 

Tyler EJ, Gutierrez Del Arroyo A, Hughes BK, Wallis R, Garbe JC, Stampfer MR, Koh J, Lowe R, Philpott MP, Bishop CL (2021) Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Aging Cell 20(3):e13318. https://doi.org/10.1111/acel.13318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vetuschi A, D’Alfonso A, Sferra R, Zanelli D, Pompili S, Patacchiola F, Gaudio E, Carta G (2016) Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse. Eur J Histochem 60(1):2604. https://doi.org/10.4081/ejh.2016.2604

Article  CAS  PubMed 

留言 (0)

沒有登入
gif