Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS

Alekseyev YO, Hamm ML, Essigmann JM (2004) Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo. Carcinogenesis 25(6):1045–1051. https://doi.org/10.1093/carcin/bgh098

Article  CAS  PubMed  Google Scholar 

Bedard LL, Alessi M, Davey S, Massey TE (2005) Susceptibility to aflatoxin B1-induced carcinogenesis correlates with tissue-specific differences in DNA repair activity in mouse and in rat. Cancer Res 65(4):1265–1270. https://doi.org/10.1158/0008-5472.CAN-04-3373

Article  CAS  PubMed  Google Scholar 

Buchi G, Spitzner D, Paglialunga S, Wogan GN (1973) Synthesis and toxicity evaluation of aflatoxin P1. Life Sci 13(8):1143–1149. https://doi.org/10.1016/0024-3205(73)90381-0

Article  CAS  PubMed  Google Scholar 

Bujons J, Hsieh DP, Kado NY, Messeguer A (1995) Aflatoxin M1 8,9-epoxide: preparation and mutagenic activity. Chem Res Toxicol 8(3):328–332. https://doi.org/10.1021/tx00045a002

Article  CAS  PubMed  Google Scholar 

Burke MD, Upshall DG (1976) Species and phenobarbitone-induced differences in the kinetic constants of liver microsomal harmine O-demethylation. Xenobiotica 6(5):321–328. https://doi.org/10.3109/00498257609151643

Article  CAS  PubMed  Google Scholar 

Cenis JL (1992) Rapid extraction of fungal DNA for PCR amplification. Nucleic Acids Res 20(9):2380. https://doi.org/10.1093/nar/20.9.2380

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chatterjee S, Bijsmans ITGW, van Mil SWC, Augustijns P, Annaert P (2014) Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates. Toxicol in Vitro 28(2):218–230. https://doi.org/10.1016/j.tiv.2013.10.020

Article  CAS  PubMed  Google Scholar 

Ch’ih JJ, Biedrzycka DW, Devlin TM (1991) Isolated hepatocytes are capable of excreting aflatoxin metabolites. Biochem Biophys Res Commu 178(3):1002–1007. https://doi.org/10.1016/0006-291X(91)90991-F

Article  CAS  Google Scholar 

Cole KE, Hsu IC, Trump BF (1986) Comparative ultrastructural effects of aflatoxin B1 on mouse, rat, and human hepatocytes in primary culture. Cancer Res 46(3):1290–1296

CAS  PubMed  Google Scholar 

Coskun E, Jaruga P, Vartanian V, Erdem O, Egner PA, Groopman JD, Lloyd RS, Dizdaroglu M (2019) Aflatoxin-guanine DNA adducts and oxidatively induced DNA damage in aflatoxin-treated mice in Vivo as measured by liquid chromatography-tandem mass spectrometry with isotope dilution. Chem Res Toxicol 32(1):80–89. https://doi.org/10.1021/acs.chemrestox.8b00202

Article  CAS  PubMed  Google Scholar 

Croy RG, Wogan GN (1981) Temporal patterns of covalent DNA adducts in rat liver after single and multiple doses of aflatoxin B1. Cancer Res 41(1):197–203

CAS  PubMed  Google Scholar 

Croy RG, Essigmann JM, Reinhold VN, Wogan GN (1978) Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver. Proc Natl Acad Sci U S A 75(4):1745–1749. https://doi.org/10.1073/pnas.75.4.1745

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dahms R, Gurtoo HL (1976) Metabolism of aflatoxin B1 to aflatoxins Q1, M1 and P1 by mouse and rat. Res Commun Chem Pathol Pharmacol 15(1):11–20

CAS  PubMed  Google Scholar 

Dalezios J, Wogan GN, Weinreb SM (1971) Aflatoxin P1: a new aflatoxin metabolite in monkeys. Science 171(3971):584–585. https://doi.org/10.1126/science.171.3971.584

Article  CAS  PubMed  Google Scholar 

Degen GH, Neumann H-G (1978) The major metabolite of aflatoxin B1 in the rat is a glutathione conjugate. Chem-Biol Interact 22(2–3):239–255. https://doi.org/10.1016/0009-2797(78)90129-1

Article  CAS  PubMed  Google Scholar 

Degen GH, Neumann HG (1981) Differences in aflatoxin B1-susceptibility of rat and mouse are correlated with the capability in vitro to inactivate aflatoxin B1-epoxide. Carcinogenesis 2(4):299–306. https://doi.org/10.1093/carcin/2.4.299

Article  CAS  PubMed  Google Scholar 

Deng J, Zhao L, Zhang N-Y, Karrow NA, Krumm CS, Qi D-S, Sun L-H (2018) Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents. Mutat Res, Rev Mutat Res 778:79–89. https://doi.org/10.1016/j.mrrev.2018.10.002

Article  CAS  PubMed  Google Scholar 

Dohnal V, Wu Q, Kuča K (2014) Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences. Arch Toxicol 88(9):1635–1644. https://doi.org/10.1007/s00204-014-1312-9

Article  CAS  PubMed  Google Scholar 

Eaton DL, Gallagher EP (1994) Mechanisms of aflatoxin carcinogenesis. Annu Rev Pharmacol Toxicol 34:135–172. https://doi.org/10.1146/annurev.pa.34.040194.001031

Article  CAS  PubMed  Google Scholar 

Eaton DL, Monroe DH, Bellamy G, Kalman DA (1988) Identification of a novel dihydroxy metabolite of aflatoxin B1 produced in vitro and in vivo in rats and mice. Chem Res Toxicol 1(2):108–114. https://doi.org/10.1021/tx00002a004

Article  CAS  PubMed  Google Scholar 

EFSA Contam PANEL (2020) Scientific opinion-Risk assessment of aflatoxins in food. EFSA 18(3):e06040. https://doi.org/10.2903/j.efsa.2020.6040

Article  Google Scholar 

Egner PA, Yu X, Johnson JK, Nathasingh CK, Groopman JD, Kensler TW, Roebuck BD (2003) Identification of aflatoxin M1–N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1. Chem Res Toxicol 16(9):1174–1180. https://doi.org/10.1021/tx034106u

Article  CAS  PubMed  Google Scholar 

Essigmann JM, Croy RG, Nadzan AM, Busby WF, Reinhold VN, Büchi G, Wogan GN (1977) Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro. Proc Natl Acad Sci U S A 74(5):1870–1874. https://doi.org/10.1073/pnas.74.5.1870

Article  CAS  PubMed  PubMed Central  Google Scholar 

Essigmann JM, Croy RG, Bennet RA, Wogan GN (1982) Metabolic activation of aflatoxin B1: patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis. Drug Metab Rev 13(4):581–602

Article  CAS  PubMed  Google Scholar 

Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen RO (2018) Comparison of In Vitro hepatic scoparone 7-O-demethylation between humans and experimental animals. Planta Med 84(5):320–328. https://doi.org/10.1055/s-0043-119886

Article  CAS  PubMed  Google Scholar 

Gallagher EP, Kunze KL, Stapleton PL, Eaton DL (1996) The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol Appl Pharmac 141(2):595–606. https://doi.org/10.1006/taap.1996.0326

Article  CAS  Google Scholar 

Gao Y-N, Yang X, Wang J-Q, Liu H-M, Zheng N (2022) Multi-omics reveal additive cytotoxicity effects of aflatoxin B1 and aflatoxin M1 toward intestinal NCM460 cells. Toxins 14(6):368. https://doi.org/10.3390/toxins14060368

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghallab A, Hassan R, Myllys M, Albrecht W, Friebel A, Hoehme S, Hofmann U, Seddek A-L, Braeuning A, Kuepfer L, Cramer B, Humpf H-U, Boor P, Degen GH, Hengstler JG (2021) Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney. Arch Toxicol 95(6):2163–2177. https://doi.org/10.1007/s00204-021-03073-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Godoy P, Hewitt NJ, Albrecht U et al (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 87(8):1315–1530. https://doi.org/10.1007/s00204-013-1078-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Green CE, Rice DW, Hsieh DP, Byard JL (1982) The comparative metabolism and toxic potency of aflatoxin B1 and aflatoxin M1 in primary cultures of adult-rat hepatocytes. Food Chem Toxicol 20(1):53–60. https://doi.org/10.1016/s0278-6915(82)80009-4

Article  CAS  PubMed  Google Scholar 

Guengerich FP, Johnson WW, Ueng YF, Yamazaki H, Shimada T (1996) Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. Environ Health Perspect 104(Suppl 3):557–562. https://doi.org/10.1289/ehp.96104s3557

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guengerich FP, Johnson WW, Shimada T, Ueng YF, Yamazaki H, Langouët S (1998) Activation and detoxication of aflatoxin B1. Mutat Res 402(1–2):121–128. https://doi.org/10.1016/S0027-5107(97)00289-3

Article  CAS  PubMed  Google Scholar 

Hanigan HM, Laishes BA (1984) Toxicity of aflatoxin B1 in rat and mouse hepatocytes in vivo and in vitro. Toxicology 30(3):185–193. https://doi.org/10.1016/0300-483x(84)90090-8

Article  CAS  PubMed 

留言 (0)

沒有登入
gif