López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243–78. https://doi.org/10.1016/j.cell.2022.11.001.
Article CAS PubMed Google Scholar
Weber KA, Achenbach LA, Coates JD. Microorganisms pumping iron: anaerobic microbial iron oxidation and reduction. Nat Rev Microbiol. 2006;4(10):752–64. https://doi.org/10.1038/nrmicro1490.
Article CAS PubMed Google Scholar
Coffey R, Ganz T. Iron homeostasis: an anthropocentric perspective. J Biol Chem. 2017;292(31):12727–34. https://doi.org/10.1074/jbc.R117.781823.
Article CAS PubMed PubMed Central Google Scholar
Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263–8. https://doi.org/10.1182/blood-2004-05-1812.
Article CAS PubMed Google Scholar
Zeidan RS, Han SM, Leeuwenburgh C, Xiao R. Iron homeostasis and organismal aging. Ageing Res Rev. 2021;72:101510. https://doi.org/10.1016/j.arr.2021.101510.
Article CAS PubMed PubMed Central Google Scholar
Casale G, Bonora C, Migliavacca A, Zurita IE, de Nicola P. Serum ferritin and ageing. Age Ageing. 1981;10(2):119–22. https://doi.org/10.1093/ageing/10.2.119.
Article CAS PubMed Google Scholar
Liu B, Sun Y, Xu G, Snetselaar LG, Ludewig G, Wallace RB, Bao W. Association between body iron status and leukocyte telomere length, a biomarker of biological aging, in a nationally representative sample of US adults. J Acad Nutr Dietetics. 2019;119(4):617–25. https://doi.org/10.1016/j.jand.2018.09.007.
Höhn A, Jung T, Grimm S, Grune T. Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells. Free Rad Biol Med. 2010;48(8):1100–8. https://doi.org/10.1016/j.freeradbiomed.2010.01.030.
Article CAS PubMed Google Scholar
Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genetics. 2018;19(6):371–84. https://doi.org/10.1038/s41576-018-0004-3.
Article CAS PubMed Google Scholar
Kane AE, Sinclair DA. Epigenetic changes during aging and their reprogramming potential. Crit Rev Biochem Mol Biol. 2019;54(1):61–83. https://doi.org/10.1080/10409238.2019.1570075.
Article CAS PubMed PubMed Central Google Scholar
Seale K, Horvath S, Teschendorff A, Eynon N, Voisin S. Making sense of the ageing methylome. Nat Rev Genet. 2022;23(10):585–605. https://doi.org/10.1038/s41576-022-00477-6.
Article CAS PubMed Google Scholar
Jylhävä J, Pedersen NL, Hägg S. Biological age predictors. EBioMedicine. 2017;21:29–36. https://doi.org/10.1016/j.ebiom.2017.03.046.
Article PubMed PubMed Central Google Scholar
Gibson J, Russ TC, Clarke TK, Howard DM, Hillary RF, Evans KL, Walker RM, Bermingham ML, Morris SW, Campbell A, et al. A meta-analysis of genome-wide association studies of epigenetic age acceleration. PLoS Genet. 2019;15(11):e1008104. https://doi.org/10.1371/journal.pgen.1008104.
Article CAS PubMed PubMed Central Google Scholar
Yarmolinsky J, Wade KH, Richmond RC, Langdon RJ, Bull CJ, Tilling KM, Relton CL, Lewis SJ, Davey Smith G, Martin RM. Causal inference in cancer epidemiology: what is the role of mendelian randomization? Cancer Epidemiol Biomarkers Prev. 2018;27(9):995–1010. https://doi.org/10.1158/1055-9965.Epi-17-1177.
Article CAS PubMed PubMed Central Google Scholar
Labrecque J, Swanson SA. Understanding the assumptions underlying instrumental variable analyses: a brief review of falsification strategies and related tools. Curr Epidemiol Rep. 2018;5(3):214–20. https://doi.org/10.1007/s40471-018-0152-1.
Article PubMed PubMed Central Google Scholar
McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Davies G, Broer L, Guo X, Jeong A, Jung J, et al. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biol. 2021;22(1):194. https://doi.org/10.1186/s13059-021-02398-9.
Article CAS PubMed PubMed Central Google Scholar
Pan Y, Sun X, Huang Z, Zhang R, Li C, Anderson AH, Lash JP, Kelly TN. Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study. Clin Epigenetics. 2023;15(1):61. https://doi.org/10.1186/s13148-023-01476-y.
Article PubMed PubMed Central Google Scholar
Kasvosve I, Delanghe J. Total iron binding capacity and transferrin concentration in the assessment of iron status. Clin Chem Lab Med. 2002;40(10):1014–8. https://doi.org/10.1515/cclm.2002.176.
Article CAS PubMed Google Scholar
Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G, Ramond A, Sørensen E, Halldorsson GH, Paul DS, et al. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Commun Biol. 2021;4(1):156. https://doi.org/10.1038/s42003-020-01575-z.
Article CAS PubMed PubMed Central Google Scholar
Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab. 2012;15(6):918–24. https://doi.org/10.1016/j.cmet.2012.03.018.
Article CAS PubMed PubMed Central Google Scholar
Bulvik BE, Berenshtein E, Konijn AM, Grinberg L, Vinokur V, Eliashar R, Chevion MM. Aging is an organ-specific process: changes in homeostasis of iron and redox proteins in the rat. Age (Dordr). 2012;34(3):693–704. https://doi.org/10.1007/s11357-011-9268-7.
Article CAS PubMed Google Scholar
Busti F, Campostrini N, Martinelli N, Girelli D. Iron deficiency in the elderly population, revisited in the hepcidin era. Front Pharmacol. 2014;5:83. https://doi.org/10.3389/fphar.2014.00083.
Article CAS PubMed PubMed Central Google Scholar
Tian Y, Tian Y, Yuan Z, Zeng Y, Wang S, Fan X, Yang D, Yang M. Iron metabolism in aging and age-related diseases. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23073612.
Article PubMed PubMed Central Google Scholar
Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI, et al. Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis. Redox Biol. 2018;14:100–15. https://doi.org/10.1016/j.redox.2017.08.015.
Article CAS PubMed Google Scholar
Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol. 2014;10(1):9–17. https://doi.org/10.1038/nchembio.1416.
Article CAS PubMed Google Scholar
Brunk UT, Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Rad Biol Med. 2002;33(5):611–9. https://doi.org/10.1016/s0891-5849(02)00959-0.
Article CAS PubMed Google Scholar
Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107–25. https://doi.org/10.1038/s41422-020-00441-1.
Article CAS PubMed Google Scholar
Braymer JJ, Lill R. Iron-sulfur cluster biogenesis and trafficking in mitochondria. J Biol Chem. 2017;292(31):12754–63. https://doi.org/10.1074/jbc.R117.787101.
Article CAS PubMed PubMed Central Google Scholar
Massie HR, Aiello VR, Williams TR. Inhibition of iron absorption prolongs the life span of Drosophila. Mech Ageing Dev. 1993;67(3):227–37. https://doi.org/10.1016/0047-6374(93)90001-8.
Article CAS PubMed Google Scholar
Schiavi A, Maglioni S, Palikaras K, Shaik A, Strappazzon F, Brinkmann V, Torgovnick A, Castelein N, De Henau S, Braeckman BP, et al. Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Curr Biol CB. 2015;25(14):1810–22. https://doi.org/10.1016/j.cub.2015.05.059.
Article CAS PubMed Google Scholar
Ren Y, Yang S, Tan G, Ye W, Liu D, Qian X, Ding Z, Zhong Y, Zhang J, Jiang D, et al. Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans. PLoS ONE. 2012;7(1):e29666. https://doi.org/10.1371/journal.pone.0029666.
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