Achudhan D, Li-Yun Chang S, Liu SC, Lin YY, Huang WC, Wu YC, Huang CC, Tsai CH, Ko CY, Kuo YH, Tang CH (2022) Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res 66. https://doi.org/10.29219/fnr.v66.8645

Bell RD, Zlokovic BV (2009) Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease. Acta Neuropathol 118(1):103–113. https://doi.org/10.1007/s00401-009-0522-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bianchi VE, Locatelli V, Rizzi L (2017) Neurotrophic and Neuroregenerative Effects of GH/IGF1. Int J Mol Sci 18(11):2441. https://doi.org/10.3390/ijms18112441

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castillo EM, Goodman-Gruen D, Kritz-Silverstein D, Morton DJ, Wingard DL, Barrett-Connor E (2003) Sarcopenia in elderly men and women: the Rancho Bernardo study. Am J Prev Med 25(3):226–231. https://doi.org/10.1016/s0749-3797(03)00197-1

Article  PubMed  Google Scholar 

Chang WS, Tsai CW, Yang JS, Hsu YM, Shih LC, Chiu HY, Bau DT, Tsai FJ (2021) Resveratrol inhibited the metastatic behaviors of cisplatin-resistant human oral cancer cells via phosphorylation of ERK/p-38 and suppression of MMP-2/9. J Food Biochem 45(6):e13666. https://doi.org/10.1111/jfbc.13666

Chen M-S, Tsai BC-K, Sitorus MA, Kuo C-H, Kuo W-W, Chen T-S, Fu C-Y, Ho T-J, Huang C-Y, Ju D-T (2022) Epigallocatechin-3-gallate pretreatment improves autologous adipose-derived stem cells against rheumatoid arthritis-induced neuroinflammation in the brain of collagen-induced rats. Neurotox Res 40(5):1223–1234. https://doi.org/10.1007/s12640-022-00544-0

Article  CAS  PubMed  Google Scholar 

Chen MY, Tsai BC, Kuo WW, Kuo CH, Lin YM, Hsieh DJ, Pai PY, Liao SC, Huang SE, Lee SD, Huang CY (2023) Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes. Am J Chin Med 1–22. https://doi.org/10.1142/s0192415x23500556

Cheng SM, Ho TJ, Yang AL, Chen IJ, Kao CL, Wu FN, Lin JA, Kuo CH, Ou HC, Huang CY, Lee SD (2013) Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats. Int J Cardiol 167(2):478–485. https://doi.org/10.1016/j.ijcard.2012.01.031

Article  PubMed  Google Scholar 

Chentli F, Azzoug S, Mahgoun S (2015) Diabetes mellitus in elderly. Indian J Endocrinol Metab 19(6):744–752. https://doi.org/10.4103/2230-8210.167553

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chong ZZ, Wang S, Shang YC, Maiese K (2012) Targeting cardiovascular disease with novel SIRT1 pathways. Future Cardiol 8(1):89–100. https://doi.org/10.2217/fca.11.76

Article  CAS  PubMed  Google Scholar 

Corder EH, Ervin JF, Lockhart E, Szymanski MH, Schmechel DE (2005) Hulette CM (2005) Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC. J Biomed Biotechnol 2:189–197. https://doi.org/10.1155/JBB.2005.189

Article  CAS  Google Scholar 

Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R (2005) Reduced risk of Alzheimer’s disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimers Dement 1(1):11–18. https://doi.org/10.1016/j.jalz.2005.06.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui S, Lv X, Li W, Li Z, Liu H, Gao Y, Huang G (2018) Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox Biol 19:81–91. https://doi.org/10.1016/j.redox.2018.08.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng JS, Lee SD, Kuo WW, Fan MJ, Lin YM, Hu WS, Huang YC, Velmurugan BK, Tsai FJ, Tsai CH, Huang CY (2014) Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Chem Biol Interact 209:77–84. https://doi.org/10.1016/j.cbi.2013.11.017

Article  CAS  PubMed  Google Scholar 

Donmez G, Guarente L (2010) Aging and disease: connections to sirtuins. Aging Cell 9(2):285–290. https://doi.org/10.1111/j.1474-9726.2010.00548.x

Article  CAS  PubMed  Google Scholar 

Dupuis L, Gonzalez de Aguilar JL, Oudart H, de Tapia M, Barbeito L, Loeffler JP (2004) Mitochondria in amyotrophic lateral sclerosis: a trigger and a target. Neurodegener Dis 1(6):245–254. https://doi.org/10.1159/000085063

Article  PubMed  Google Scholar 

Finegold JA, Asaria P, Francis DP (2013) Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol 168(2):934–945. https://doi.org/10.1016/j.ijcard.2012.10.046

Article  PubMed  PubMed Central  Google Scholar 

Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147(4):742–758. https://doi.org/10.1016/j.cell.2011.10.033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gabbouj S, Ryhänen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, Martiskainen H, Tanila H, Haapasalo A, Hiltunen M, Natunen T (2019) Altered Insulin Signaling in Alzheimer’s Disease Brain - Special Emphasis on PI3K-Akt Pathway. Front Neurosci 13:629. https://doi.org/10.3389/fnins.2019.00629

Article  PubMed  PubMed Central  Google Scholar 

Gueant JL, Namour F, Gueant-Rodriguez RM, Daval JL (2013) Folate and fetal programming: a play in epigenomics? Trends Endocrinol Metab 24(6):279–289. https://doi.org/10.1016/j.tem.2013.01.010

Article  CAS  PubMed  Google Scholar 

Henchcliffe C, Beal MF (2008) Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 4(11):600–609. https://doi.org/10.1038/ncpneuro0924

Article  CAS  PubMed  Google Scholar 

Hsieh YL, Teng HJ, Yeh YH, Hsieh CH, Huang CY (2018) The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer’s Diseased Mice Hearts. Mar Drugs 16(8):263. https://doi.org/10.3390/md16080263

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang CY, Kuo WW, Yeh YL, Ho TJ, Lin JY, Lin DY, Chu CH, Tsai FJ, Tsai CH, Huang CY (2014) ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell Death Differ 21(8):1262–1274. https://doi.org/10.1038/cdd.2014.46

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang CY, Su YC, Lu CY, Chiu PL, Chang YM, Ju DT, Chen RJ, Yang LY, Ho TJ, Kao HC (2022) Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer’s disease model mice by suppressing cardiac hypertrophy and fibrosis. Environ Toxicol 37(7):1740–1749. https://doi.org/10.1002/tox.23521

Article  CAS  PubMed  Google Scholar 

Huang CY, Yang AL, Lin YM, Wu FN, Lin JA, Chan YS, Tsai FJ, Tsai CH, Kuo CH, Lee SD (2012) Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts. J Appl Physiol (1985) 112(5):883–891. https://doi.org/10.1152/japplphysiol.00605.2011

Hunter JJ, Chien KR (1999) Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 341(17):1276–1283. https://doi.org/10.1056/NEJM199910213411706

Article  CAS  PubMed  Google Scholar 

Jeyapalan JC, Sedivy JM (2008) Cellular senescence and organismal aging. Mech Ageing Dev 129(7–8):467–474. https://doi.org/10.1016/j.mad.2008.04.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JY, Mondaca-Ruff D, Singh S, Wang Y (2022) SIRT1 and Autophagy: Implications in Endocrine Disorders. Front Endocrinol (Lausanne) 13:930919. https://doi.org/10.3389/fendo.2022.930919

Kitada M, Koya D (2013) SIRT1 in type 2 diabetes: mechanisms and therapeutic potential. Diabetes Metab J 37(5):315–325. https://doi.org/10.4093/dmj.2013.37.5.315

Article  PubMed  PubMed Central  Google Scholar 

Klaunig JE, Kamendulis LM (2004) The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44:239–267. https://doi.org/10.1146/annurev.pharmtox.44.101802.121851

Article  CAS  PubMed  Google Scholar 

Koay K-P, Tsai BC-K, Kuo C-H, Kuo W-W, Luk H-N, Day CH, Chen R-J, Chen MY-C, Padma VV, Huang C-Y (2021) Hyperglycemia-Induced Cardiac Damage Is Alleviated by Heat-Inactivated Lactobacillus reuteri GMNL-263 via Activation of the IGF1R Survival Pathway. Probiotics Antimicrob Proteins 13(4):1044–1053. https://doi.org/10.1007/s12602-021-09745-z

Article  CAS  PubMed  Google Scholar 

Kumar R, Chaterjee P, Sharma PK, Singh AK, Gupta A, Gill K, Tripathi M, Dey AB, Dey S (2013) Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease. PloS one 8(4):e61560. https://doi.org/10.1371/journal.pone.0061560

Lai CH, Van Thao D, Tsai BCK, Hsieh DJY, Chen MYC, Kuo WW, Kuo CH, Lu SY, Liao SC, Lin KH (2022) Insulin-like growth factor II receptor alpha overexpression in heart aggravates hyperglycemia-induced cardiac inflammation and myocardial necrosis. Environ Toxicol 38(3):676–684. https://doi.org/10.1002/tox.23717

Article  CAS  PubMed  Google Scholar 

Leszek J, Mikhaylenko EV, Belousov DM, Koutsouraki E, Szczechowiak K, Kobusiak-Prokopowicz M, Mysiak A, Diniz BS, Somasundaram SG, Kirkland CE, Aliev G (2021) The Links between Cardiovascular Diseases and Alzheimer’s Disease. Curr Neuropharmacol 19(2):152–169. https://doi.org/10.2174/1570159x18666200729093724

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases. Clin Interv Aging 13:757–772. https://doi.org/10.2147/cia.S158513

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu G, Yao L, Liu J, Jiang Y, Ma G, Genetic, Environmental Risk for Alzheimer's disease C, Chen Z, Zhao B, Li K, (2014) Cardiovascular disease contributes to Alzheimer’s disease: evidence from large-scale genome-wide association studies. Neurobiol Aging 35(4):786–792. https://doi.org/10.1016/j.neurobiolaging.2013.10.084

Liu SP, Shibu MA, Tsai FJ, Hsu YM, Tsai CH, Chung JG, Yang JS, Tang CH, Wang S, Li Q, Huang CY (2020) Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1alpha induced BNIP3 expressi