PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study

Masoli M, Holt S, Weatherall M, Beasley R. The dose-response relationship of inhaled corticosteroids in asthma. Curr Allergy Asthma Rep. 2004;4(2):144–8.

Article  PubMed  Google Scholar 

Salamé J, Tyan P, Salameh P, Waked M. Hyperreactive airway disease in adults: data from a national study in Lebanon. Lebanese Med J. 2014;62(3):143–9.

Article  Google Scholar 

Akiki Z, Saadeh D, Farah R, Hallit S, Sacre H, Hosseini H, et al. Asthma prevalence and associated factors among Lebanese adults: the first national survey. BMC Pulm Med. 2021;21(1):162.

Article  PubMed  PubMed Central  Google Scholar 

Accordini S, Corsico A, Cerveri I, Gislason D, Gulsvik A, Janson C, et al. The socio-economic burden of asthma is substantial in Europe. Allergy. 2008;63(1):116–24.

Article  CAS  PubMed  Google Scholar 

National Asthma Education and Prevention Program TEPotDaMoA. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma: Clinical Practice Guidelines. Bethesda (MD)2007.

Bahadori K, Doyle-Waters MM, Marra C, Lynd L, Alasaly K, Swiston J, et al. Economic burden of asthma: a systematic review. BMC Pulm Med. 2009;9:24.

Article  PubMed  PubMed Central  Google Scholar 

Cisternas MG, Blanc PD, Yen IH, Katz PP, Earnest G, Eisner MD, et al. A comprehensive study of the direct and indirect costs of adult asthma. J Allergy Clin Immunol. 2003;111(6):1212–8.

Article  PubMed  Google Scholar 

Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46(5):1308–21.

Article  CAS  PubMed  Google Scholar 

Buhl R, Humbert M, Bjermer L, Chanez P, Heaney LG, Pavord I, et al. Severe eosinophilic asthma: a roadmap to consensus. Eur Respir J. 2017;49(5):1700634.

Article  PubMed  Google Scholar 

Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–73.

Article  CAS  PubMed  Google Scholar 

Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet. 2002;360(9347):1715–21.

Article  PubMed  Google Scholar 

Bakakos A, Loukides S, Bakakos P. Severe eosinophilic asthma. J Clin Med. 2019;8(9):1375.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014;371(13):1189–97.

Article  PubMed  Google Scholar 

Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–9.

Article  CAS  PubMed  Google Scholar 

Casciano J, Krishnan JA, Small MB, Buck PO, Gopalan G, Li C, et al. Burden of asthma with elevated blood eosinophil levels. BMC Pulm Med. 2016;16(1):100.

Article  PubMed  PubMed Central  Google Scholar 

Price DB, Rigazio A, Campbell JD, Bleecker ER, Corrigan CJ, Thomas M, et al. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Lancet Respir Med. 2015;3(11):849–58.

Article  PubMed  Google Scholar 

Castro M, Wenzel SE, Bleecker ER, Pizzichini E, Kuna P, Busse WW, et al. Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med. 2014;2(11):879–90.

Article  CAS  PubMed  Google Scholar 

Corren J, Weinstein S, Janka L, Zangrilli J, Garin M. Phase 3 study of reslizumab in patients with poorly controlled asthma: effects across a broad range of eosinophil counts. Chest. 2016;150(4):799–810.

Article  PubMed  Google Scholar 

Possa SS, Leick EA, Prado CM, Martins MA, Tibério IF. Eosinophilic inflammation in allergic asthma. Front Pharmacol. 2013;4:46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walford HH, Doherty TA. Diagnosis and management of eosinophilic asthma: a US perspective. J Asthma Allergy. 2014;7:53–65.

PubMed  PubMed Central  Google Scholar 

de Groot JC, Ten Brinke A, Bel EH. Management of the patient with eosinophilic asthma: a new era begins. ERJ Open Res. 2015;1(1):00024.

Article  PubMed  PubMed Central  Google Scholar 

Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160(3):1001–8.

Article  CAS  PubMed  Google Scholar 

Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med. 2008;178(3):218–24.

Article  PubMed  Google Scholar 

Al-Jahdali H, Wali S, Albanna AS, Allehebi R, Al-Matar H, Fattouh M, et al. Prevalence of eosinophilic, atopic, and overlap phenotypes among patients with severe asthma in Saudi Arabia: a cross-sectional study. BMC Pulm Med. 2022;22(1):67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Global Initiative for Asthma. Global strategy for asthma management and prevention. 2022.

Weir CB, Jan A. BMI Classification percentile and cut off points. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.

Nagasaki T, Sato K, Kume N, Oguma T, Sunadome H, Ito I, et al. The prevalence and disease burden of severe eosinophilic asthma in Japan. J Asthma. 2019;56(11):1147–58.

Article  PubMed  Google Scholar 

Athanazio R, Stelmach R, Antila M, Machado A, Arruda LK, Neto A, et al. Cross-sectional, observational study to estimate the prevalence of the eosinophilic phenotype for Brazilian patients with severe asthma: the BRAEOS study. Eur Respir J. 2020;56(suppl 64):205.

Google Scholar 

Hamilton D, Lehman H. Asthma phenotypes as a guide for current and future biologic therapies. Clin Rev Allergy Immunol. 2020;59(2):160–74.

Article  CAS  PubMed  Google Scholar 

Fuseini H, Newcomb DC. Mechanisms driving gender differences in asthma. Curr Allergy Asthma Rep. 2017;17(3):19.

Article  PubMed  PubMed Central  Google Scholar 

Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018;141(4):1169–79.

Article  PubMed  PubMed Central  Google Scholar 

Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J. 2004;24(5):822–33.

Article  CAS  PubMed  Google Scholar 

Bantulà M, Roca-Ferrer J, Arismendi E, Picado C. Asthma and obesity: two diseases on the rise and bridged by inflammation. J Clin Med. 2021;10(2):169.

Article  PubMed  PubMed Central  Google Scholar 

Sideleva O, Suratt BT, Black KE, Tharp WG, Pratley RE, Forgione P, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012;186(7):598–605.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Global Initiative for Asthma. Global strategy for asthma management and prevention. 2021.

Humbert M, Beasley R, Ayres J, Slavin R, Hébert J, Bousquet J, et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005;60(3):309–16.

Article  CAS  PubMed  Google Scholar 

Weinstein SF, Katial R, Jayawardena S, Pirozzi G, Staudinger H, Eckert L, et al. Efficacy and safety of dupilumab in perennial allergic rhinitis and comorbid asthma. J Allergy Clin Immunol. 2018;142(1):171-7.e1.

Article  CAS  PubMed  Google Scholar 

Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198–207.

Article  PubMed  Google Scholar 

Benralizumab (Fasenra) for Severe Eosinophilic Asthma. Jama. 2018;319(14):1501–2.

Marques Mello L, Viana KP, Moraes dos Santos F, Saturnino LT, Kormann ML, Lazaridis E, et al. Severe asthma and eligibility for biologics in a Brazilian cohort. J Asthma. 2021;58(7):958–66.

Article  CAS  PubMed  Google Scholar 

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