Martínez de Toda I, Maté I, Vida C, Cruces J, De la Fuente M. Immune function parameters as markers of biological age and predictors of longevity. Aging. 2016;8:3110–9. https://doi.org/10.18632/aging.101116.
Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25:1822–32. https://doi.org/10.1038/s41591-019-0675-0.
Article CAS PubMed Central PubMed Google Scholar
Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007;128:92–105. https://doi.org/10.1016/j.mad.2006.11.016.
Article CAS PubMed Google Scholar
Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14:576–90. https://doi.org/10.1038/S41574-018-0059-4.
Article CAS PubMed Google Scholar
Aiello A, Farzaneh F, Candore G, Caruso C, Davinelli S, Gambino CM, et al. Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention. Front Immunol. 2019;10:2247. https://doi.org/10.3389/fimmu.2019.02247.
Article CAS PubMed Central PubMed Google Scholar
Franceschi C, Ostan R, Mariotti S, Monti D, Vitale G. The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective. Endocr Rev. 2019;40:1250–70. https://doi.org/10.1210/er.2018-00170.
Asperges E, Albi G, Zuccaro V, Sambo M, Pieri TC, Calia M, et al. Dynamic NLR and PLR in Predicting COVID-19 Severity: A Retrospective Cohort Study. Infect Dis Ther. 2023;12:1625–40. https://doi.org/10.1007/s40121-023-00813-1.
Article PubMed Central PubMed Google Scholar
de Dios E, Rios-Navarro C, Perez-Sole N, Gavara J, Marcos-Garces V, Rodríguez E, et al. Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19. J Clin Med. 2020;9:3484. https://doi.org/10.3390/jcm9113484.
Article CAS PubMed Central PubMed Google Scholar
Wilson D, Drew W, Jasper A, Crisford H, Nightingale P, Newby P, et al. Frailty Is Associated With Neutrophil Dysfunction Which Is Correctable With Phosphoinositol-3-Kinase Inhibitors. Journals Gerontol Ser A. 2020;75:2320–5. https://doi.org/10.1093/gerona/glaa216.
Paganelli R, Scala E, Quinti I, Ansotegui IJ. Humoral immunity in aging. Aging (Milano). 1994;6:143–50. https://doi.org/10.1007/BF03324229.
Article CAS PubMed Google Scholar
Cao Dinh H, Njemini R, Onyema OO, Beyer I, Liberman K, De Dobbeleer L, et al. Strength Endurance Training but Not Intensive Strength Training Reduces Senescence-Prone T Cells in Peripheral Blood in Community-Dwelling Elderly Women. J Gerontol A Biol Sci Med Sci. 2019;74:1870–8. https://doi.org/10.1093/gerona/gly229.
Article CAS PubMed Google Scholar
Grilz E, Posch F, Königsbrügge O, Schwarzinger I, Lang IM, Marosi C, et al. Association of Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with the Risk of Thromboembolism and Mortality in Patients with Cancer. Thromb Haemost. 2018;118:1875–84. https://doi.org/10.1055/s-0038-1673401.
Shah N, Parikh V, Patel N, Patel N, Badheka A, Deshmukh A, et al. Neutrophil lymphocyte ratio significantly improves the Framingham risk score in prediction of coronary heart disease mortality: insights from the National Health and Nutrition Examination Survey-III. Int J Cardiol. 2014;171:390–7. https://doi.org/10.1016/j.ijcard.2013.12.019.
Li H, Lu X, Xiong R, Wang S. High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients. Mediators Inflamm. 2017; 2017: 9327136. https://doi.org/10.1155/2017/9327136.
Jhuang Y-H, Kao T-W, Peng T-C, Chen W-L, Li Y-W, Chang P-K, et al. Neutrophil to lymphocyte ratio as predictor for incident hypertension: a 9-year cohort study in Taiwan. Hypertens Res. 2019;42:1209–14. https://doi.org/10.1038/s41440-019-0245-3.
Article PubMed Central PubMed Google Scholar
Fest J, Ruiter TR, Groot Koerkamp B, Rizopoulos D, Ikram MA, van Eijck CHJ, et al. The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study. Eur J Epidemiol. 2019;34:463–70. https://doi.org/10.1007/s10654-018-0472-y.
Article CAS PubMed Google Scholar
Tap L, Corsonello A, Di Rosa M, Fabbietti P, Formiga F, Moreno-González R, et al. Inflammaging and Blood Pressure Profiles in Late Life: The Screening for CKD among Older People across Europe (SCOPE) Study. J Clin Med. 2022;11. https://doi.org/10.3390/jcm11247311.
Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85 + Study. Mech Ageing Dev. 2012;133:456–66. https://doi.org/10.1016/J.MAD.2012.05.005.
Article CAS PubMed Google Scholar
Kara SP, Altunan B, Unal A. Investigation of the peripheral inflammation (neutrophil–lymphocyte ratio) in two neurodegenerative diseases of the central nervous system. Neurol Sci. 2022;43:1799–807. https://doi.org/10.1007/s10072-021-05507-5.
Rembach A, Watt AD, Wilson WJ, Rainey-Smith S, Ellis KA, Rowe CC, et al. An increased neutrophil–lymphocyte ratio in Alzheimer’s disease is a function of age and is weakly correlated with neocortical amyloid accumulation. J Neuroimmunol. 2014;273:65–71. https://doi.org/10.1016/J.JNEUROIM.2014.05.005.
Article CAS PubMed Google Scholar
Pawelec G. Age and immunity: What is immunosenescence? Exp Gerontol. 2018;105:4–9. https://doi.org/10.1016/j.exger.2017.10.024.
Article CAS PubMed Google Scholar
Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H. Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment. Front Immunol. 2016;7. https://doi.org/10.3389/fimmu.2016.00502.
Olsson J, Wikby A, Johansson B, Löfgren S, Nilsson B-O, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev. 2001;121:187–201. https://doi.org/10.1016/S0047-6374(00)00210-4.
Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listi’ F, et al. Immunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics. Rejuvenation Res. 2008;11:425–32. https://doi.org/10.1089/rej.2008.0662.
Article CAS PubMed Google Scholar
Tough DF, Sprent J. Life span of naive and memory t cells. Stem Cells. 1995;13:242–9. https://doi.org/10.1002/STEM.5530130305.
Article CAS PubMed Google Scholar
Henson SM, Lanna A, Riddel NE, Franzese O, Macaulay R, Griffiths SJ, et al. p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells. J Clin Invest. 2014;124:4004–16. https://doi.org/10.1172/JCI75051.
Article CAS PubMed Central PubMed Google Scholar
Pereira BI, De Maeyer RPH, Covre LP, Nehar-Belaid D, Lanna A, Ward S, et al. Sestrins induce natural killer function in senescent-like CD8 + T cells. Nat Immunol. 2020;21:684–94. https://doi.org/10.1038/S41590-020-0643-3.
Article CAS PubMed Central PubMed Google Scholar
Frasca D, Blomberg BB, Paganelli R. Aging, obesity, and inflammatory age-related diseases. Front Immunol. 2017;8. https://doi.org/10.3389/FIMMU.2017.01745.
Cancro MP, Age-Associated B, Cells. Annu Rev Immunol. 2020;38:315–40. https://doi.org/10.1146/ANNUREV-IMMUNOL-092419-031130.
Article CAS PubMed Google Scholar
Salvioli S, Monti D, Lanzarini C, Conte M, Pirazzini C, Giulia Bacalini M, et al. Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised. Curr Pharm Des. 2013;19:1675–9. https://doi.org/10.2174/1381612811319090015.
Article CAS PubMed Google Scholar
Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC, et al. Neutrophils: New insights and open questions. Sci Immunol. 2018;3. https://doi.org/10.1126/sciimmunol.aat4579.
Koenderman L, Tesselaar K, Vrisekoop N. Human neutrophil kinetics: a call to revisit old evidence. Trends Immunol. 2022;43:868–76. https://doi.org/10.1016/J.IT.2022.09.008.
Article CAS PubMed Google Scholar
Summers C, Rankin SM, Condliffe AM, Singh N, Peters AM, Chilvers ER. Neutrophil kinetics in health and disease. Trends Immunol. 2010;31:318–24. https://doi.org/10.1016/j.it.2010.05.006.
Article CAS PubMed Central PubMed Google Scholar
Lee KA, Flores RR, Jang IH, Saathoff A, Robbins PD. Immune Senescence, Immunosenescence and Aging. Front aging. 2022;3. https://doi.org/10.3389/FRAGI.2022.900028.
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, et al. The conundrum of human immune system senescence. Mech Ageing Dev. 2020;192:111357. https://doi.org/10.1016/j.mad.2020.111357.
Article CAS PubMed Central PubMed Google Scholar
Franceschi C, Salvioli S, Garagnani P, de Eguileor M, Monti D, Capri M. Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity. Front Immunol. 2017;8. https://doi.org/10.3389/FIMMU.2017.00982.
Marrella V, Facoetti A, Cassani B. Cellular Senescence in Immunity against Infections. Int J Mol Sci. 2022;23. https://doi.org/10.3390/IJMS231911845.
Ferrucci L, Gonzalez-Freire M, Fabbri E, Simonsick E, Tanaka T, Moore Z, et al. Measuring biological aging in humans: A quest. Aging Cell. 2020;19. https://doi.org/10.1111/acel.13080.
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10:573–91. https://doi.org/10.18632/AGING.101414.
留言 (0)