Friend C. Cell-free transmission in adult swiss mice of a disease having the character of a leukemia. J Exp Med. 1957;105:307–18.

Article  CAS  Google Scholar 

Steeves RA. Editorial: Spleen focus-forming virus in Friend and Rauscher leukemia virus preparations. J Natl Cancer Inst. 1975;54:289–97.

Article  CAS  Google Scholar 

Miyazawa M, Tsuji-Kawahara S, Kanari Y. Host genetic factors that control immune responses to retrovirus infections. Vaccine. 2008;26:2981–96.

Article  CAS  Google Scholar 

Persons DA, Paulson RF, Loyd MR, Herley MT, Bodner SM, Bernstein A, Correll PH, Ney PA. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nat Genet. 1999;23:159–65.

Article  CAS  Google Scholar 

Cmarik J, Ruscetti S. Friend spleen focus-forming virus activates the tyrosine kinase sf-Stk and the transcription factor PU.1 to cause a multi-stage erythroleukemia in mice. Viruses. 2010;2:2235–57.

Article  CAS  Google Scholar 

Moreau-Gachelin F. Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation. Retrovirology. 2008;5:99.

Article  Google Scholar 

Mirand EA, Steeves RA, Lange RD, Grace JT Jr. Virus-induced polycythemia in mice: erythropoiesis without erythropoietin. Proc Soc Exp Biol Med. 1968;128:844–9.

Article  CAS  Google Scholar 

Tambourin P, Wendling F. Malignant transformation and erythroid differentiation by polycythaemia-inducing Friend virus. Nat New Biol. 1971;234:230–3.

Article  CAS  Google Scholar 

Liao SK, Axelrad AA. Erythropoietin-independent erythroid colony formation in vitro by hemopoietic cells of mice infected with Friend virus. Int J Cancer. 1975;15:467–82.

Article  CAS  Google Scholar 

Mager D, MacDonald ME, Robson IB, Mak TW, Bernstein A. Clonal analysis of the late stages of erythroleukemia induced by two distinct strains of Friend leukemia virus. Mol Cell Biol. 1981;1:721–30.

CAS  Google Scholar 

Clark SP, Mak TW. Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein. Proc Natl Acad Sci USA. 1983;80:5037–41.

Article  CAS  Google Scholar 

Iwashiro M, Kondo T, Shimizu T, Yamagishi H, Takahashi K, Matsubayashi Y, Masuda T, Otaka A, Fujii N, Ishimoto A, et al. Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. J Virol. 1993;67:4533–42.

Article  CAS  Google Scholar 

Chen W, Qin H, Chesebro B, Cheever MA. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J Virol. 1996;70:7773–82.

Article  CAS  Google Scholar 

Messer RJ, Lavender KJ, Hasenkrug KJ. Mice of the resistant H-2(b) haplotype mount broad CD4(+) T cell responses against 9 distinct Friend virus epitopes. Virology. 2014;456–457:139–44.

Article  Google Scholar 

Kleiser C, Schneider J, Bayer H, Hunsmann G. Immunoprevention of Friend leukaemia virus-induced erythroleukaemia by vaccination with aggregated gp70. J Gen Virol. 1986;67(Pt 9):1901–7.

Article  CAS  Google Scholar 

Ishihara C, Miyazawa M, Nishio J, Chesebro B. Induction of protective immunity to Friend murine leukemia virus in genetic nonresponders to virus envelope protein. J Immunol. 1991;146:3958–63.

CAS  Google Scholar 

Miyazawa M, Fujisawa R, Ishihara C, Takei YA, Shimizu T, Uenishi H, Yamagishi H, Kuribayashi K. Immunization with a single T helper cell epitope abrogates Friend virus-induced early erythroid proliferation and prevents late leukemia development. J Immunol. 1995;155:748–58.

CAS  Google Scholar 

Dittmer U, Werner T, Kraft AR. Co-immunization of mice with a retroviral DNA vaccine and GITRL-encoding plasmid augments vaccine-induced protection against retrovirus infection. Viral Immunol. 2008;21:459–67.

Article  CAS  Google Scholar 

Bongard N, Lapuente D, Windmann S, Dittmer U, Tenbusch M, Bayer W. Interference of retroviral envelope with vaccine-induced CD8(+) T cell responses is relieved by co-administration of cytokine-encoding vectors. Retrovirology. 2017;14:28.

Article  Google Scholar 

Schone D, Hrycak CP, Windmann S, Lapuente D, Dittmer U, Tenbusch M, Bayer W. Immunodominance of adenovirus-derived CD8(+) T cell epitopes interferes with the induction of transgene-specific immunity in adenovirus-based immunization. J Virol. 2017;91:e01184-17.

Article  Google Scholar 

Earl PL, Moss B, Morrison RP, Wehrly K, Nishio J, Chesebro B. T-lymphocyte priming and protection against Friend leukemia by vaccinia-retrovirus env gene recombinant. Science. 1986;234:728–31.

Article  CAS  Google Scholar 

Miyazawa M, Nishio J, Chesebro B. Protection against Friend retrovirus-induced leukemia by recombinant vaccinia viruses expressing the gag gene. J Virol. 1992;66:4497–507.

Article  CAS  Google Scholar 

Bongard N, Le-Trilling VTK, Malyshkina A, Ruckborn M, Wohlgemuth K, Wensing I, Windmann S, Dittmer U, Trilling M, Bayer W. Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection. PLoS Pathog. 2019;15:e1008043.

Article  CAS  Google Scholar 

Bayer W, Schimmer S, Hoffmann D, Dittmer U, Wildner O. Evaluation of the Friend virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies. Vaccine. 2008;26:716–26.

Article  CAS  Google Scholar 

Bayer W, Lietz R, Ontikatze T, Johrden L, Tenbusch M, Nabi G, Schimmer S, Groitl P, Wolf H, Berry CM, et al. Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes. Retrovirology. 2011;8:75.

Article  CAS  Google Scholar 

Godel P, Windmann S, Dietze KK, Dittmer U, Bayer W. Modification of one epitope-flanking amino acid allows for the induction of Friend retrovirus-specific CD8+ T cells by adenovirus-based immunization. J Virol. 2012;86:12422–5.

Article  Google Scholar 

Kaulfuss M, Wensing I, Windmann S, Hrycak CP, Bayer W. Induction of complex immune responses and strong protection against retrovirus challenge by adenovirus-based immunization depends on the order of vaccine delivery. Retrovirology. 2017;14:8.

Article  Google Scholar 

Hrycak CP, Windmann S, Bayer W. Comparative evaluation of the vaccine efficacies of three adenovirus-based vector types in the Friend retrovirus infection model. J Virol. 2019;93:e01155-19.

Article  Google Scholar 

Wolff L, Ruscetti S. The spleen focus-forming virus (SFFV) envelope gene, when introduced into mice in the absence of other SFFV genes, induces acute erythroleukemia. J Virol. 1988;62:2158–63.

Article  CAS  Google Scholar 

Subramanian A, Hegde S, Porayette P, Yon M, Hankey P, Paulson RF. Friend virus utilizes the BMP4-dependent stress erythropoiesis pathway to induce erythroleukemia. J Virol. 2008;82:382–93.

Article  CAS  Google Scholar 

Thomson S, Srivatanakul P. Factors influencing the assay for target cells of Friend spleen focus-forming virus. Cancer Res. 1973;33:717–20.

CAS  Google Scholar 

Opitz U, Seidel HJ. Studies on the target cell for the Friend virus (FV-P strain) using the CFU-E technique. Blut. 1978;37:183–92.

Article  CAS  Google Scholar 

Opitz U, Seidel HJ, Bertoncello I. Erythroid stem cells in Friend-virus infected mice. J Cell Physiol. 1978;96:95–104.

Article  CAS  Google Scholar 

Windmann S, Otto L, Hrycak CP, Malyshkina A, Bongard N, David P, Gunzer M, Dittmer U, Bayer W. Infection of B cell follicle-resident cells by Friend retrovirus occurs during acute infection and is maintained during viral persistence. mBio. 2019;10:e00004-19.

Article  Google Scholar 

Streeck H. AIDS virus seeks refuge in B cell follicles. Nat Med. 2015;21:111–2.

Article  CAS  Google Scholar 

Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8(+) T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018;19:475–86.

Article  CAS  Google Scholar 

Medema JP, Schuurhuis DH, Rea D, van Tongeren J, de Jong J, Bres SA, Laban S, Toes RE, Toebes M, Schumacher TN, et al. Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. J Exp Med. 2001;194:657–67.

Article  CAS  Google Scholar 

Shcherbo D, Merzlyak EM, Chepurnykh TV, Fradkov AF, Ermakova GV, Solovieva EA, Lukyanov KA, Bogdanova EA, Zaraisky AG, Lukyanov S, Chudakov DM. Bright far-red fluorescent protein for whole-body imaging. Nat Methods. 2007;4:741–6.

Article  CAS  Google Scholar 

Subach OM, Gundorov IS, Yoshimura M, Subach FV, Zhang J, Gruenwald D, Souslova EA, Chudakov DM, Verkhusha VV. Conversion of red fluorescent protein into a bright blue probe. Chem Biol. 2008;15:1116–24.

Article  CAS  Google Scholar 

Strestik BD, Olbrich ARM, Hasenkrug KJ, Dittmer U. The role of IL-5, IL-6 and IL-10 in primary and vaccine-primed immune responses to infection with Friend retrovirus (murine leukaemia virus). J Gen Virol. 2001;82:1349–54.

Article  CAS  Google Scholar 

Sitbon M, Nishio J, Wehrly K, Lodmell D, Chesebro B. Use of a focal immunofluorescence assay on live cells for quantitation of retroviruses: distinction of host range classes in virus mixtures and biological cloning of dual-tropic murine leukemia viruses. Virology. 1985;141:110–8.

Article  CAS  Google Scholar 

Hasenkrug KJ, Chesebro B. Immunity to retroviral infection: the Friend virus model. Proc Natl Acad Sci USA. 1997;94:7811–6.

Article  CAS  Google Scholar 

Denner J, Eschricht M, Lauck M, Semaan M, Schlaermann P, Ryu H, Akyüz L. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. PLoS ONE. 2012;8:e55199.

Article  Google Scholar