Abdala Valencia H, Loffredo LF, Misharin AV, Berdnikovs S (2016) Phenotypic plasticity and targeting of Siglec-F(high) CD11c(low) eosinophils to the airway in a murine model of asthma. Allergy 71(2):267–271. https://doi.org/10.1111/all.12776

CrossRef  Google Scholar 

Aegerter H, Kulikauskaite J, Crotta S, Patel H, Kelly G, Hessel EM, Mack M, Beinke S, Wack A (2020) Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat Immunol 21(2):145–157. https://doi.org/10.1038/s41590-019-0568-x

CrossRef  Google Scholar 

Arumugam P, Suzuki T, Shima K, McCarthy C, Sallese A, Wessendarp M, Ma Y, Meyer J, Black D, Chalk C, Carey B, Lachmann N, Moritz T, Trapnell BC (2019) Long-term safety and efficacy of gene-pulmonary macrophage transplantation therapy of PAP in Csf2ra mice. Mol Ther 27(9):1597–1611. https://doi.org/10.1016/j.ymthe.2019.06.010

CrossRef  Google Scholar 

Banks WA (2019) The blood-brain barrier as an endocrine tissue. Nat Rev Endocrinol 15(8):444–455. https://doi.org/10.1038/s41574-019-0213-7

CrossRef  Google Scholar 

Bansal S, Yajjala VK, Bauer C, Sun K (2018) IL-1 signaling prevents alveolar macrophage depletion during influenza and coinfection. J Immunol 200(4):1425–1433. https://doi.org/10.4049/jimmunol.1700210

CrossRef  Google Scholar 

Bao L, Deng W, Huang B, Gao H, Liu J, Ren L, Wei Q, Yu P, Xu Y, Qi F, Qu Y, Li F, Lv Q, Wang W, Xue J, Gong S, Liu M, Wang G, Wang S, Song Z, Zhao L, Liu P, Zhao L, Ye F, Wang H, Zhou W, Zhu N, Zhen W, Yu H, Zhang X, Guo L, Chen L, Wang C, Wang Y, Wang X, Xiao Y, Sun Q, Liu H, Zhu F, Ma C, Yan L, Yang M, Han J, Xu W, Tan W, Peng X, Jin Q, Wu G, Qin C (2020) The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Nature 583(7818):830–833. https://doi.org/10.1038/s41586-020-2312-y

CrossRef  Google Scholar 

Becerra-Díaz M, Strickland AB, Keselman A, Heller NM (2018) Androgen and androgen receptor as enhancers of M2 macrophage polarization in allergic lung inflammation. J Immunol 201(10):2923–2933. https://doi.org/10.4049/jimmunol.1800352

CrossRef  Google Scholar 

Beckmann A, Grissmer A, Meier C, Tschernig T (2020a) Intercellular communication between alveolar epithelial cells and macrophages. Ann Anat 227:151417. https://doi.org/10.1016/j.aanat.2019.151417

CrossRef  Google Scholar 

Beckmann N, Sutton JM, Hoehn RS, Jernigan PL, Friend LA, Johanningman TA, Schuster RM, Lentsch AB, Caldwell CC, Pritts TA (2020b) IFNγ and TNFα mediate CCL22/MDC production in alveolar macrophages after hemorrhage and resuscitation. Am J Physiol Lung Cell Mol Physiol 318(5):L864–L872. https://doi.org/10.1152/ajplung.00455.2019

CrossRef  Google Scholar 

Bellamri N, Viel R, Morzadec C, Lecureur V, Joannes A, de Latour B, Llamas-Gutierrez F, Wollin L, Jouneau S, Vernhet L (2020) TNF-α and IL-10 control CXCL13 expression in human macrophages. J Immunol 204(9):2492–2502. https://doi.org/10.4049/jimmunol.1900790

CrossRef  Google Scholar 

Bhattacharya J, Westphalen K (2016) Macrophage-epithelial interactions in pulmonary alveoli. Semin Immunopathol 38(4):461–469. https://doi.org/10.1007/s00281-016-0569-x

CrossRef  Google Scholar 

Bogdan C, Schleicher U (2006) Production of interferon-gamma by myeloid cells – fact or fancy? Trends Immunol 27(6):282–290

Google Scholar 

Bonfield TL, Konstan MW, Burfeind P, Panuska JR, Hilliard JB, Berger M (1995) Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis. Am J Respir Cell Mol Biol 13(3):257–261

Google Scholar 

Brunet K, Arrivé F, Martellosio J-P, Lamarche I, Marchand S, Rammaert B (2021) Corticosteroids alter alveolar macrophage control of Lichtheimia corymbifera spores in an ex vivo mouse model. Med Mycol 59(7):694–700. https://doi.org/10.1093/mmy/myaa104

CrossRef  Google Scholar 

Byrne AJ, Powell JE, O'Sullivan BJ, Ogger PP, Hoffland A, Cook J, Bonner KL, Hewitt RJ, Wolf S, Ghai P, Walker SA, Lukowski SW, Molyneaux PL, Saglani S, Chambers DC, Maher TM, Lloyd CM (2020) Dynamics of human monocytes and airway macrophages during healthy aging and after transplant. J Exp Med 217(3). https://doi.org/10.1084/jem.20191236

Carvalho-Sousa CE, Pereira EP, Kinker GS, Veras M, Ferreira ZS, Barbosa-Nunes FP, Martins JO, Saldiva PHN, Reiter RJ, Fernandes PA, da Silveira C-MS, Markus RP (2020) Immune-pineal axis protects rat lungs exposed to polluted air. J Pineal Res 68(3):e12636. https://doi.org/10.1111/jpi.12636

CrossRef  Google Scholar 

Chanteux H, Guisset AC, Pilette C, Sibille Y (2007) LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms. Respir Res 8:71

Google Scholar 

Cheng P, Li S, Chen H (2021) Macrophages in lung injury, repair, and fibrosis. Cell 10(2). https://doi.org/10.3390/cells10020436

Cohen M, Giladi A, Gorki A-D, Solodkin DG, Zada M, Hladik A, Miklosi A, Salame T-M, Halpern KB, David E, Itzkovitz S, Harkany T, Knapp S, Amit I (2018) Lung single-cell signaling interaction map reveals basophil role in macrophage imprinting. Cell 175(4). https://doi.org/10.1016/j.cell.2018.09.009

Cooper AM (2009) Cell-mediated immune responses in tuberculosis. Annu Rev Immunol 27:393–422. https://doi.org/10.1146/annurev.immunol.021908.132703

CrossRef  Google Scholar 

Cui H, Xie N, Banerjee S, Ge J, Jiang D, Dey T, Matthews QL, Liu R-M, Liu G (2021) Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation. Am J Respir Cell Mol Biol 64(1):115–125. https://doi.org/10.1165/rcmb.2020-0360OC

CrossRef  Google Scholar 

Doyle AD, Mukherjee M, LeSuer WE, Bittner TB, Pasha SM, Frere JJ, Neely JL, Kloeber JA, Shim KP, Ochkur SI, Ho T, Svenningsen S, Wright BL, Rank MA, Lee JJ, Nair P, Jacobsen EA (2019) Eosinophil-derived IL-13 promotes emphysema. Eur Respir J 53(5). https://doi.org/10.1183/13993003.01291-2018

Du S, Li C, Lu Y, Lei X, Zhang Y, Li S, Liu F, Chen Y, Weng D, Chen J (2019) Dioscin alleviates crystalline silica-induced pulmonary inflammation and fibrosis through promoting alveolar macrophage autophagy. Theranostics 9(7):1878–1892. https://doi.org/10.7150/thno.29682

CrossRef  Google Scholar 

Epelman S, Lavine KJ, Randolph GJ (2014) Origin and functions of tissue macrophages. Immunity 41(1):21–35. https://doi.org/10.1016/j.immuni.2014.06.013

CrossRef  Google Scholar 

Feng Z, Zhou J, Liu Y, Xia R, Li Q, Yan L, Chen Q, Chen X, Jiang Y, Chao G, Wang M, Zhou G, Zhang Y, Wang Y, Xia H (2021) Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response. Cell Death Differ 28(7):2238–2256. https://doi.org/10.1038/s41418-021-00750-x

CrossRef  Google Scholar 

Fenton MJ, Vermeulen MW, Kim S, Burdick M, Strieter RM, Kornfeld H (1997) Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis. Infect Immun 65(12):5149–5156

Google Scholar 

Gao DK, Salomonis N, Henderlight M, Woods C, Thakkar K, Grom AA, Thornton S, Jordan MB, Wikenheiser-Brokamp KA, Schulert GS (2021) IFN-γ is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. JCI Insight 6(17). https://doi.org/10.1172/jci.insight.147593

Garcia-Reyero N (2018) The clandestine organs of the endocrine system. Gen Comp Endocrinol 257:264–271. https://doi.org/10.1016/j.ygcen.2017.08.017

CrossRef  Google Scholar 

Glass CK, Natoli G (2016) Molecular control of activation and priming in macrophages. Nat Immunol 17(1):26–33. https://doi.org/10.1038/ni.3306

CrossRef  Google Scholar 

Grant RA, Morales-Nebreda L, Markov NS, Swaminathan S, Querrey M, Guzman ER, Abbott DA, Donnelly HK, Donayre A, Goldberg IA, Klug ZM, Borkowski N, Lu Z, Kihshen H, Politanska Y, Sichizya L, Kang M, Shilatifard A, Qi C, Lomasney JW, Argento AC, Kruser JM, Malsin ES, Pickens CO, Smith SB, Walter JM, Pawlowski AE, Schneider D, Nannapaneni P, Abdala-Valencia H, Bharat A, Gottardi CJ, Budinger GRS, Misharin AV, Singer BD, Wunderink RG (2021) Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia. Nature 590(7847):635–641. https://doi.org/10.1038/s41586-020-03148-w

CrossRef  Google Scholar 

Gschwend J, Sherman SPM, Ridder F, Feng X, Liang H-E, Locksley RM, Becher B, Schneider C (2021) Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth. J Exp Med 218(10). https://doi.org/10.1084/jem.20210745

Guilliams M, De Kleer I, Henri S, Post S, Vanhoutte L, De Prijck S, Deswarte K, Malissen B, Hammad H, Lambrecht BN (2013) Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J Exp Med 210(10):1977–1992. https://doi.org/10.1084/jem.20131199

CrossRef  Google Scholar 

Hamidzadeh K, Christensen SM, Dalby E, Chandrasekaran P, Mosser DM (2017) Macrophages and the recovery from acute and chronic inflammation. Annu Rev Physiol 79:567–592. https://doi.org/10.1146/annurev-physiol-022516-034348

CrossRef  Google Scholar 

Hamilton JA (2002) GM-CSF in inflammation and autoimmunity. Trends Immunol 23(8):403–408

Google Scholar 

Happle C, Lachmann N, Škuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G (2014) Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Sci Transl Med 6(250):250ra113. https://doi.org/10.1126/scitranslmed.3009750

CrossRef  Google Scholar 

Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M (2013) Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38(4):792–804. https://doi.org/10.1016/j.immuni.2013.04.004

CrossRef  Google Scholar 

Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M, Murphy KM, García-Sastre A, Merad M (2012) Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest 122(11):4037–4047. https://doi.org/10.1172/JCI60659

CrossRef  Google Scholar 

Hou F, Xiao K, Tang L, Xie L (2021) Diversity of macrophages in lung homeostasis and diseases. Front Immunol 12:753940. https://doi.org/10.3389/fimmu.2021.753940

CrossRef  Google Scholar 

Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M (2019) Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenge. Immunity 51(5). https://doi.org/10.1016/j.immuni.2019.10.010

Huaux F, Lo Re S, Giordano G, Uwambayinema F, Devosse R, Yakoub Y, Panin N, Palmai-Pallag M, Rabolli V, Delos M, Marbaix E, Dauguet N, Couillin I, Ryffel B, Renauld J-C, Lison D (2015) IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation. J Pathol 235(5):698–709. https://doi.org/10.1002/path.4487

CrossRef  Google Scholar 

Hussell T, Bell TJ (2014) Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol 14(2):81–93. https://doi.org/10.1038/nri3600

CrossRef  Google Scholar 

Isler P, de Rochemonteix BG, Songeon F, Boehringer N, Nicod LP (1999) Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10. Am J Respir Cell Mol Biol 20(2):270–278

Google Scholar 

Ji J-J, Sun Q-M, Nie D-Y, Wang Q, Zhang H, Qin F-F, Wang Q-S, Lu S-F, Pang G-M, Lu Z-G (2021) Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis. Acta Pharmacol Sin 42(10):1630–1641. https://doi.org/10.1038/s41401-020-00573-5

CrossRef  Google Scholar 

Kaur M, Smyth LJ, Cadden P, Grundy S, Ray D, Plumb J, Singh D (2012) T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease. Respir Res 13:20. https://doi.org/10.1186/1465-9921-13-20

CrossRef  Google Scholar 

Khalaj K, Figueira RL, Antounians L, Lauriti G, Zani A (2020) Systematic review of extracellular vesicle-based treatments for lung injury: are EVs a potential therapy for COVID-19? J Extracell Vesicles 9(1):1795365. https://doi.org/10.1080/20013078.2020.1795365

CrossRef  Google Scholar 

Khan N, Mendonca L, Dhariwal A, Fontes G, Menzies D, Xia J, Divangahi M, King IL (2019) Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis. Mucosal Immunol 12(3):772–783. https://doi.org/10.1038/s41385-019-0147-3

CrossRef  Google Scholar 

Kim Y-G, Udayanga KGS, Totsuka N, Weinberg JB, Núñez G, Shibuya A (2014) Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2. Cell Host Microbe 15(1). https://doi.org/10.1016/j.chom.2013.12.010

Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, Akira S (2007) Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity 27(2):240–252

Google Scholar 

Kurihara C, Lecuona E, Wu Q, Yang W, Núñez-Santana FL, Akbarpour M, Liu X, Ren Z, Li W, Querrey M, Ravi S, Anderson ML, Cerier E, Sun H, Kelly ME, Abdala-Valencia H, Shilatifard A, Mohanakumar T, Budinger GRS, Kreisel D, Bharat A (2021) Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment. JCI Insight 6(6). https://doi.org/10.1172/jci.insight.147282

Lambrecht BN (2006) Alveolar macrophage in the driver's seat. Immunity 24(4):366–368

Google Scholar 

Lang FM, Lee KMC, Teijaro JR, Becher B, Hamilton JA (2020) GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches. Nat Rev Immunol 20(8):507–514. https://doi.org/10.1038/s41577-020-0357-7

CrossRef