Roles of Intramolecular Interactions in the Regulation of TRP Channels

Alberts B, Alexander J, Lewis J, Raff M, Roberts K, Walter P (2002) Molecular biology of the cell, 4th edn. Garland Science, New York

Google Scholar 

Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, Cheng Y (2018) Structure of the human TRPM4 ion channel in a lipid nanodisc. Science 359:228–232

Google Scholar 

Bai Y, Yu X, Chen H, Horne D, White R, Wu X, Lee P, Gu Y, Ghimire-Rijal S, Lin DC et al (2020) Structural basis for pharmacological modulation of the TRPC6 channel. eLife 9

Google Scholar 

Bamps D, Vriens J, de Hoon J, Voets T (2021) TRP channel cooperation for nociception: therapeutic opportunities. Annu Rev Pharmacol Toxicol 61:655–677

Google Scholar 

Bargal R, Avidan N, Ben-Asher E, Olender Z, Zeigler M, Frumkin A, Raas-Rothschild A, Glusman G, Lancet D, Bach G (2000) Identification of the gene causing mucolipidosis type IV. Nat Genet 26:118–123

Google Scholar 

Bhardwaj R, Lindinger S, Neuberger A, Nadezhdin KD, Singh AK, Cunha MR, Derler I, Gyimesi G, Reymond JL, Hediger MA et al (2020) Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv 6

Google Scholar 

Boukalova S, Marsakova L, Teisinger J, Vlachova V (2010) Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels. J Biol Chem 285:41455–41462

Google Scholar 

Cai R, Liu X, Zhang R, Hofmann L, Zheng W, Amin MR, Wang L, Hu Q, Peng JB, Michalak M et al (2020) Autoinhibition of TRPV6 channel and regulation by PIP2. iScience 23:101444

Google Scholar 

Cai R, Wang L, Liu X, Michalak M, Tang J, Peng JB, Chen XZ (2021) Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion. Commun Biol 4:990

Google Scholar 

Cao E (2020) Structural mechanisms of transient receptor potential ion channels. J Gen Physiol 152

Google Scholar 

Cao E, Liao M, Cheng Y, Julius D (2013) TRPV1 structures in distinct conformations reveal activation mechanisms. Nature 504:113–118

Google Scholar 

Chen Q, She J, Zeng W, Guo J, Xu H, Bai XC, Jiang Y (2017) Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550:415–418

Google Scholar 

Chen HW, Yen CC, Kuo LL, Lo CW, Huang CS, Chen CC, Lii CK (2020) Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells. Toxicol Appl Pharmacol 393:114941

Google Scholar 

Clapham DE (2007) SnapShot: mammalian TRP channels. Cell 129:220

Google Scholar 

Colton CK, Zhu MX (2007) 2-Aminoethoxydiphenyl borate as a common activator of TRPV1, TRPV2, and TRPV3 channels. Handb Exp Pharmacol:173–187

Google Scholar 

Cosens DJ, Manning A (1969) Abnormal electroretinogram from a drosophila mutant. Nature 224:285–287

Google Scholar 

Damann N, Voets T, Nilius B (2008) TRPs in our senses. Curr Biol 18:R880–R889

Google Scholar 

Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J (2019) Structural insight into TRPV5 channel function and modulation. Proc Natl Acad Sci U S A 116:8869–8878

Google Scholar 

Daumy X, Amarouch MY, Lindenbaum P, Bonnaud S, Charpentier E, Bianchi B, Nafzger S, Baron E, Fouchard S, Thollet A et al (2016) Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I. Int J Cardiol 207:349–358

Google Scholar 

de Almeida AS, Bernardes LB, Trevisan G (2021) TRP channels in cancer pain. Eur J Pharmacol 904:174185

Google Scholar 

Deng HX, Klein CJ, Yan J, Shi Y, Wu Y, Fecto F, Yau HJ, Yang Y, Zhai H, Siddique N et al (2010) Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet 42:165–169

Google Scholar 

Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P (2018) Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat Struct Mol Biol 25:252–260

Google Scholar 

Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ, Yuan P (2020) Gating of human TRPV3 in a lipid bilayer. Nat Struct Mol Biol 27:635–644

Google Scholar 

Dhani SU, Bear CE (2006) Role of intramolecular and intermolecular interactions in ClC channel and transporter function. Pflugers Arch 451:708–715

Google Scholar 

Di Palma F, Belyantseva IA, Kim HJ, Vogt TF, Kachar B, Noben-Trauth K (2002) Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc Natl Acad Sci U S A 99:14994–14999

Google Scholar 

Dill KA, Ozkan SB, Shell MS, Weikl TR (2008) The protein folding problem. Annu Rev Biophys 37:289–316

Google Scholar 

Diver MM, Cheng Y, Julius D (2019) Structural insights into TRPM8 inhibition and desensitization. Science 365:1434–1440

Google Scholar 

Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H (2009) Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem 284:32040–32052

Google Scholar 

Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG (2019) Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol 26:40–49

Google Scholar 

Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J (2018a) Structure of the mouse TRPC4 ion channel. Nat Commun 9:3102

Google Scholar 

Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE (2018b) Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc Natl Acad Sci U S A 115:E8201–E8210

Google Scholar 

Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE (2018c) Structure of full-length human TRPM4. Proc Natl Acad Sci U S A 115:2377–2382

Google Scholar 

Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y et al (2019) Cryo-EM structure of TRPC5 at 2.8-A resolution reveals unique and conserved structural elements essential for channel function. Sci Adv 5:eaaw7935

Google Scholar 

Fan C, Choi W, Sun W, Du J, Lu W (2018) Structure of the human lipid-gated cation channel TRPC3. eLife 7

Google Scholar 

Fine M, Schmiege P, Li X (2018) Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun 9:4192

Google Scholar 

Froghi S, Grant CR, Tandon R, Quaglia A, Davidson B, Fuller B (2021) New insights on the role of TRP channels in calcium signalling and immunomodulation: review of pathways and implications for clinical practice. Clin Rev Allergy Immunol 60:271–292

Google Scholar 

Galione A, Chuang KT (2020) Pyridine nucleotide metabolites and calcium release from intracellular stores. Adv Exp Med Biol 1131:371–394

Google Scholar 

Gao Y, Cao E, Julius D, Cheng Y (2016) TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature 534:347–351

Google Scholar 

Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R et al (2017) Structure of the polycystic kidney disease TRP channel polycystin-2 (PC2). Nat Struct Mol Biol 24:114–122

Google Scholar 

Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y (2017) Structures of the calcium-activated, non-selective cation channel TRPM4. Nature 552:205–209

Google Scholar 

Heber S, Gold-Binder M, Ciotu CI, Witek M, Ninidze N, Kress HG, Fischer MJM (2019) A human TRPA1-specific pain model. J Neurosci 39:3845–3855

Google Scholar 

Hermosura MC, Nayakanti H, Dorovkov MV, Calderon FR, Ryazanov AG, Haymer DS, Garruto RM (2005) A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Proc Natl Acad Sci U S A 102:11510–11515

Google Scholar 

Hermosura MC, Cui AM, Go RC, Davenport B, Shetler CM, Heizer JW, Schmitz C, Mocz G, Garruto RM, Perraud AL (2008) Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci U S A 105:18029–18034

Google Scholar 

Hirschi M, Herzik MA Jr, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY (2017) Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature 550:411–414

Google Scholar 

Huang Y, Winkler PA, Sun W, Lu W, Du J (2018) Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature 562:145–149

Google Scholar 

Huang Y, Fliegert R, Guse AH, Lu W, Du J (2020) A structural overview of the ion channels of the TRPM family. Cell Calcium 85:102111

Google Scholar 

Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V et al (2018) Structural insights on TRPV5 gating by endogenous modulators. Nat Commun 9:4198

Google Scholar 

Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC 3rd, Filizola M, Rohacs T, Moiseenkova-Bell VY (2019) Structure-based characterization of novel TRPV5 inhibitors. eLife 8

Google Scholar 

Jia Q, Tian W, Li B, Chen W, Zhang W, Xie Y, Cheng N, Chen Q, Xiao J, Zhang Y et al (2021) Transient receptor potential channels, TRPV1 and TRPA1 in melanocytes synergize UV-dependent and UV-independent melanogenesis. Br J Pharmacol 178:4646–4662

Google Scholar 

Julius D (2013) TRP channels and pain. Annu Rev Cell Dev Biol 29:355–384

Google Scholar 

Kadamur G, Ross EM (2013) Mammalian phospholipase C. Annu Rev Physiol 75:127–154

Google Scholar 

Kaneko Y, Szallasi A (2014) Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol 171:2474–2507

Google Scholar 

Kass RS (2006) Sodium channel inactivation in heart: a novel role of the carboxy-terminal domain. J Cardiovasc Electrophysiol 17(Suppl 1):S21–S25

Google Scholar 

Kim KM, Wijerathne T, Hur JH, Kang UJ, Kim IH, Kweon YC, Lee AR, Jeong SJ, Lee SK, Lee YY et al (2018) Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans. Proc Natl Acad Sci U S A 115:E4623–E4632

Google Scholar 

Krakow D, Vriens J, Camacho N, Luong P, Deixler H, Funari TL, Bacino CA, Irons MB, Holm IA, Sadler L et al (2009) Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet 84:307–315

Google Scholar 

Landoure G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH et al (2010) Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet 42:170–174

Google Scholar 

Lee CM, Lee DS, Jung WK, Yoo JS, Yim MJ, Choi YH, Park S, Seo SK, Choi JS, Lee YM et al (2016) Benzyl isothiocyanate inhibits inflammasome activation in E. coli LPS-stimulated BV2 cells. Int J Mol Med 38:912–918

Google Scholar 

Lewis AH, Grandl J (2020) Inactivation kinetics and mechanical gating of Piezo1 ion channels depend on subdomains within the cap. Cell Rep 30(870–880):e872

Google Scholar 

Li H (2017) TRP channel classification. Adv Exp Med Biol 976:1–8

Google Scholar 

Li M, Yu Y, Yang J (2011) Structural biology of TRP channels. Adv Exp Med Biol 704:1–23

Google Scholar 

Liao M, Cao E, Julius D, Cheng Y (2013) Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature 504:107–112

Google Scholar 

Loukin S, Su Z, Zhou X, Kung C (2010) Forward genetic analysis reveals multiple gating mechanisms of TRPV4. J Biol Chem 285:19884–19890

Google Scholar 

Mackie K (2008) Cannabinoid receptors: where they are and what they do. J Neuroendocrinol 20(Suppl 1):10–14

Google Scholar 

Maier T, Follmann M, Hessler G, Kleemann HW, Hachtel S, Fuchs B, Weissmann N, Linz W, Schmidt T, Lohn M et al (2015) Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol 172:3650–3660

Google Scholar 

Mandadi S, Armati PJ, Roufogalis BD (2011) Protein kinase C modulation of thermo-sensitive transient receptor potential channels: implications for pain signaling. J Nat Sci Biol Med 2:13–25

Google Scholar 

Mandal K (2020) Review of PIP2 in cellular signaling, functions and diseases. Int J Mol Sci 21

Google Scholar 

Maruyama T, Kanaji T, Nakade S, Kanno T, Mikoshiba K (1997) 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release. J Biochem 122:498–505

Google Scholar 

McGoldrick LL, Singh AK, Saotome K, Yelshanskaya MV, Twomey EC, Grassucci RA, Sobolevsky AI (2018) Opening of the human epithelial calcium channel TRPV6. Nature 553:233–237

Google Scholar 

Mochizuki T, Wu G, Hayashi T, Xenophontos SL, Veldhuisen B, Saris JJ, Reynolds DM, Cai Y, Gabow PA, Pierides A et al (1996) PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 272:1339–1342

留言 (0)

沒有登入
gif