Chung JK, Lee SY, Park M, Joo EJ, Kim SA. Investigation of mitochondrial DNA copy number in patients with major depressive disorder. Psychiatry Res. 2019;282:112616.
Article CAS PubMed Google Scholar
Elbatarny M, Lu YT, Hu M, Coles J, Mital S, Ross-White A, et al. Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review. EBioMedicine. 2025;118:105839.
Article CAS PubMed PubMed Central Google Scholar
Tharayil SP, Shukla P. Connecting the dots: mitochondrial dysfunction, PCOS, and insulin resistance-insights and therapeutic advances. Int J Mol Sci. 2025;26(13):6233. https://doi.org/10.3390/ijms26136233.
Article CAS PubMed PubMed Central Google Scholar
Wei P, Zhang X, Yan C, Sun S, Chen Z, Lin F. Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic strategies. Biogerontology. 2025;26:142.
Article PubMed PubMed Central Google Scholar
Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;290:457–65.
Article CAS PubMed Google Scholar
Liu Z, Fu Q, Shao Y, Duan X. The role of mitochondrial DNA copy number in autoimmune disease: a bidirectional two sample Mendelian randomization study. Front Immunol. 2024;15:1409969.
Article CAS PubMed PubMed Central Google Scholar
Castellani CA, Longchamps RJ, Sun J, Guallar E, Arking DE. Thinking outside the nucleus: mitochondrial DNA copy number in health and disease. Mitochondrion. 2020;53:214–23.
Article CAS PubMed PubMed Central Google Scholar
Harerimana NV, Paliwali D, Romero-Molina C, Bennett DA, Pa J, Goate A, et al. The role of mitochondrial genome abundance in Alzheimer’s disease. Alzheimers Dement. 2023;19:2069–83.
Article CAS PubMed Google Scholar
Ashar FN, Zhang Y, Longchamps RJ, Lane J, Moes A, Grove ML, et al. Association of mitochondrial DNA copy number with cardiovascular disease. JAMA Cardiol. 2017;2:1247–55.
Article PubMed PubMed Central Google Scholar
Qin P, Qin T, Liang L, Li X, Jiang B, Wang X, et al. The role of mitochondrial DNA copy number in cardiometabolic disease: a bidirectional two-sample Mendelian randomization study. Cardiovasc Diabetol. 2024;23:45.
Article CAS PubMed PubMed Central Google Scholar
Liu X, Longchamps RJ, Wiggins KL, Raffield LM, Bielak LF, Zhao W, et al. Association of mitochondrial DNA copy number with cardiometabolic diseases. Cell Genom. 2021;1(1):514–21. https://doi.org/10.1016/j.xgen.2021.100006.
Green R, Allen LH, Bjørke-Monsen A-L, Brito A, Guéant J-L, Miller JW, et al. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017;3:1–20.
Stepien KM, Heaton R, Rankin S, Murphy A, Bentley J, Sexton D, et al. Evidence of oxidative stress and secondary mitochondrial dysfunction in metabolic and non-metabolic disorders. J Clin Med. 2017;6(7):71. https://doi.org/10.3390/jcm6070071.
Article CAS PubMed PubMed Central Google Scholar
Chandler RJ, Zerfas PM, Shanske S, Sloan J, Hoffmann V, DiMauro S, et al. Mitochondrial dysfunction in mut methylmalonic acidemia. FASEB J. 2009;23:1252–61.
Article CAS PubMed PubMed Central Google Scholar
Solmi M, Radua J, Olivola M, Croce E, Soardo L, Salazar de Pablo G, Il Shin J, Kirkbride JB, Jones P, Kim JH, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Mol Psychiatry. 2022;27:281–95.
Article CAS PubMed Google Scholar
Pan G, Fu Q, Xu Y, Jiang L. Evidence for a causal link between lipoprotein (a) and mental disorders: a retrospective and Mendelian randomization study. J Affect Disord. 2025;374:397–407. https://doi.org/10.1016/j.jad.2025.01.038.
Article CAS PubMed Google Scholar
Krystal JH, State MW. Psychiatric disorders: diagnosis to therapy. Cell. 2014;157:201–14.
Article CAS PubMed PubMed Central Google Scholar
Area-Gomez E, Guardia-Laguarta C, Schon EA, Przedborski S. Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas. J Clin Invest. 2019;129:34–45.
Article PubMed PubMed Central Google Scholar
Shivakumar V, Rajasekaran A, Subbanna M, Kalmady SV, Venugopal D, Agrawal R, et al. Leukocyte mitochondrial DNA copy number in schizophrenia. Asian J Psychiatr. 2020;53:102193.
Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2020;19:609–33.
Article CAS PubMed PubMed Central Google Scholar
Kausar S, Wang F, Cui H. The role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases. Cells. 2018. https://doi.org/10.3390/cells7120274.
Article PubMed PubMed Central Google Scholar
Fu Q, Yu Q, Luo H, Liu Z, Ma X, Wang H, et al. Protective effects of Wogonin in the treatment of central nervous system and degenerative diseases. Brain Res Bull. 2025;221:111202. https://doi.org/10.1016/j.brainresbull.2025.111202
Article CAS PubMed Google Scholar
Al-Kafaji G, Jahrami HA, Alwehaidah MS, Alshammari Y, Husni M. Mitochondrial DNA copy number in autism spectrum disorder and attention deficit hyperactivity disorder: a systematic review and meta-analysis. Front Psychiatry. 2023;14:1196035.
Article PubMed PubMed Central Google Scholar
Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, et al. Molecular signatures of major depression. Curr Biol. 2015;25:1146–56.
Article CAS PubMed PubMed Central Google Scholar
Chang CC, Jou SH, Lin TT, Lai TJ, Liu CS. Mitochondria DNA change and oxidative damage in clinically stable patients with major depressive disorder. PLoS ONE. 2015;10:e0125855.
Article PubMed PubMed Central Google Scholar
Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, et al. Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder. Neuropsychopharmacology. 2018;43:1557–64.
Article CAS PubMed PubMed Central Google Scholar
Wang S, Liu Y, Liu J, Tian W, Zhang X, Cai H, et al. Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population. Redox Biol. 2020;37:101741.
Article CAS PubMed PubMed Central Google Scholar
Cao B, Xiao Y, Liu D. Associations of methylmalonic acid and depressive symptoms with mortality: a population-based study. Transl Psychiatry. 2024;14:297.
Article CAS PubMed PubMed Central Google Scholar
Fu Q, Shen T, Yu Q, Jiang L, Yang R. Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infa
Comments (0)