Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018;62:2–10.

Article  PubMed  Google Scholar 

Levine H, Jorgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, Pinotti R, Swan SH. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. 2017;23(6):646–59.

Article  PubMed  PubMed Central  Google Scholar 

Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36(6):E1–150.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Skakkebaek NE, Lindahl-Jacobsen R, Levine H, Andersson A, Jorgensen N, Main KM, Lidegaard O, Priskorn L, Holmboe SA, Brauner EV, Almstrup K, Franca LR, Znaor A, Kortenkamp A, Hart RJ, Juul A. Environmental factors in declining human fertility. Nat Rev Endocrinol. 2022;18(3):139–57.

Article  PubMed  Google Scholar 

Ilacqua A, Izzo G, Emerenziani GP, Baldari C, Aversa A. Lifestyle and fertility: the influence of stress and quality of life on male fertility. Reprod Biol Endocrin. 2018;16(1):115.

Article  CAS  Google Scholar 

Janevic T, Kahn LG, Landsbergis P, Cirillo PM, Cohn BA, Liu X, Factor-Litvak P. Effects of work and life stress on semen quality. Fertil Steril. 2014;102(2):530–8.

Article  PubMed  PubMed Central  Google Scholar 

Collaborators GMD. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiat. 2022;9(2):137–50.

Article  Google Scholar 

Yang B, Zhang J, Qi Y, Wang P, Jiang R, Li H. Assessment on Occurrences of Depression and Anxiety and Associated Risk Factors in the Infertile Chinese Men. Am J Mens Health. 2017;11(3):767–74.

Article  PubMed  PubMed Central  Google Scholar 

Mor M, Jayaseelan V, Kattimani S, Thyagaraju C, Kubera NS, Duraiswamy M. Depression, anxiety, stress, and coping among men with infertility seeking treatment at a tertiary care hospital in South India: A mixed-method study. Indian J Psychiat. 2024;66(12):1131–8.

Article  Google Scholar 

Bhongade MB, Prasad S, Jiloha RC, Ray PC, Mohapatra S, Koner BC. Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples. Andrologia. 2015;47(3):336–42.

Article  PubMed  CAS  Google Scholar 

Zorn B, Auger J, Velikonja V, Kolbezen M, Meden-Vrtovec H. Psychological factors in male partners of infertile couples: relationship with semen quality and early miscarriage. Int J Androl. 2008;31(6):557–64.

Article  PubMed  CAS  Google Scholar 

Zou P, Wang X, Sun L, Chen Q, Yang H, Zhou N, Chen H, Zhang G, Ling X, Wang Z, Gao J, Mo M, Huang L, Peng K, Chen S, Cui Z, Liu J, Ao L, Cao J. Semen Quality in Chinese College Students: Associations With Depression and Physical Activity in a Cross-Sectional Study. Psychosom Med. 2018;80(6):564–72.

Article  PubMed  Google Scholar 

Pandya CD, Howell KR, Pillai A. Antioxidants as potential therapeutics for neuropsychiatric disorders. Prog Neuro-Psychoph. 2013;46:214–23.

Article  CAS  Google Scholar 

Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH. Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrino. 2017;76:197–205.

Article  CAS  Google Scholar 

Pan Y, Wang S, Kang J, Cao T, Liu J, Zhang L, Niu S, Liu X. Association between generalized anxiety symptoms and semen quality in infertile men: A multicentre study in North China. Andrologia. 2022;54(8): e14449.

Article  PubMed  Google Scholar 

Gurhan N, Akyuz A, Atici D, Kisa S. Association of depression and anxiety with oocyte and sperm numbers and pregnancy outcomes during in vitro fertilization treatment. Psychol Rep. 2009;104(3):796–806.

Article  PubMed  Google Scholar 

Roopnarinesingh R, Keane D, Harrison R. Detecting mood disorders in men diagnosed with cancer who seek semen cryopreservation: a chance to improve service. Ir Med J 2003, 96(4): 104, 106–107.

Coward RM, Stetter C, Kunselman A, Trussell JC, Lindgren MC, Alvero RR, Casson P, Christman GM, Coutifaris C, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Robinson RD, Smith JF, Steiner AZ, Wild RA, Zhang H, Santoro N. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. J Urology. 2019;202(2):379–84.

Article  Google Scholar 

Hjollund NHI, Bonde JPE, Henriksen TB, Giwercman A, Olsen J. Reproductive effects of male psychologic stress. Epidemiology. 2004;15(1):21–7.

Article  PubMed  Google Scholar 

Piomboni P, Focarelli R, Stendardi A, Ferramosca A, Zara V. The role of mitochondria in energy production for human sperm motility. Int J Androl. 2012;35(2):109–24.

Article  PubMed  CAS  Google Scholar 

Boguenet M, Bouet P, Spiers A, Reynier P, May-Panloup P. Mitochondria: their role in spermatozoa and in male infertility. HUM REPROD UPDATE. 2021;27(4):697–719.

Article  PubMed  CAS  Google Scholar 

Ferramosca A, Zara V. Bioenergetics of mammalian sperm capacitation. BIOMED RES INT. 2014;2014: 902953.

Article  PubMed  PubMed Central  Google Scholar 

Buffone MG, Ijiri TW, Cao W, Merdiushev T, Aghajanian HK, Gerton GL. Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility. MOL REPROD DEV. 2012;79(1):4–18.

Article  PubMed  CAS  Google Scholar 

Mukai C, Travis AJ. What sperm can teach us about energy production. Reprod Domest Anim 2012, 47 Suppl 4(0 4): 164–169.

Storey BT. Mammalian sperm metabolism: oxygen and sugar, friend and foe. Int J Dev Biol. 2008;52(5–6):427–37.

Article  PubMed  CAS  Google Scholar 

Turner RM. Moving to the beat: a review of mammalian sperm motility regulation. Reprod Fert Develop. 2006;18(1–2):25–38.

Article  Google Scholar 

Asghari A, Marashi S, Ansari-Pour N. A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia. SYST Biol Reprod Med. 2017;63(2):100–12.

Article  PubMed  CAS  Google Scholar 

Paiva C, Amaral A, Rodriguez M, Canyellas N, Correig X, Ballesca JL, Ramalho-Santos J, Oliva R. Identification of endogenous metabolites in human sperm cells using proton nuclear magnetic resonance ((1) H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS). Andrology-US. 2015;3(3):496–505.

Article  CAS  Google Scholar 

Chauvin T, Xie F, Liu T, Nicora CD, Yang F, Camp DGN, Smith RD, Roberts KP. A systematic analysis of a deep mouse epididymal sperm proteome. Biol Reprod. 2012;87(6):141.

Article  PubMed  PubMed Central  Google Scholar 

Amaral A, Lourenco B, Marques M, Ramalho-Santos J. Mitochondria functionality and sperm quality. Reproduction. 2013;146(5):R163–74.

Article  PubMed  CAS  Google Scholar 

Foster DW. Malonyl-CoA: the regulator of fatty acid synthesis and oxidation. J Clin Invest. 2012;122(6):1958–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sugden MC, Kraus A, Harris RA, Holness MJ. Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Biochem J 2000, 346 Pt 3(Pt 3): 651–657.

Hou T, Zhang F, Mao X, Deng G. Chronotype and psychological distress among Chinese rural population: A moderated mediation model of sleep quality and age. PLoS ONE. 2020;15(10): e241301.

Article  Google Scholar 

Le MTH, Tran TD, Holton S, Nguyen HT, Wolfe R, Fisher J. Reliability, convergent validity and factor structure of the DASS-21 in a sample of Vietnamese adolescents. PLoS ONE. 2017;12(7): e180557.

Article  Google Scholar 

Mishra P, Negi MPS, Srivastava M, Singh K, Rajender S. Decline in seminal quality in Indian men over the last 37 years. Reprod Biol Endocrin. 2018;16(1):103.

Article  CAS  Google Scholar 

Sengupta P, Borges EJ, Dutta S, Krajewska-Kulak E. Decline in sperm count in European men during the past 50 years. Hum Exp Toxicol. 2018;37(3):247–55.