Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74:12–49

Article  PubMed  Google Scholar 

Kamat AM, Hahn NM, Efstathiou JA, Lerner SP, Malmström PU, Choi W et al (2016) Bladder cancer. Lancet 388: 2796–2810

Sylvester RJ, Rodríguez O, Hernández V, Turturica D, Bauerová L, Bruins HM et al (2021) European association of urology (EAU) prognostic factor risk groups for non-muscle-invasive bladder cancer (nmibc) incorporating the WHO 2004/2016 and WHO 1973 classification systems for grade: an update from the EAU NMIBC guidelines panel. Eur Urol 79:480–488

Article  PubMed  Google Scholar 

Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM et al (2017) EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016. Eur Urol 71:447–461

Article  PubMed  Google Scholar 

Laukhtina E, Abufaraj M, Al-Ani A, Ali MR, Mori K, Moschini M et al (2022) Intravesical therapy in patients with intermediate-risk non-muscle-invasive bladder cancer: a systematic review and network meta-analysis of disease recurrence. Eur Urol Focus 8:447–456

Article  PubMed  Google Scholar 

Morales A, Eidinger D, Bruce AW (1976) Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors. J Urol 116:180–183

Article  CAS  PubMed  Google Scholar 

Han J, Gu X, Li Y, Wu Q (2020) Mechanisms of BCG in the treatment of bladder cancer-current Understanding and the prospect. Biomed Pharmacother 129:110393

Article  CAS  PubMed  Google Scholar 

Zlotta AR, Fleshner NE, Jewett MA (2009) The management of BCG failure in non-muscle-invasive bladder cancer: an update. Can Urol Assoc J 3:S199–205

Article  PubMed  PubMed Central  Google Scholar 

Griffiths JR (1991) Are cancer cells acidic? Br J Cancer 64:425–427

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogdanov A, Bogdanov A, Chubenko V, Volkov N, Moiseenko F, Moiseyenko V (2022) Tumor acidity: from the hallmark of cancer to target of treatment. Front Oncol 12:979154

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wright ME, Michaud DS, Pietinen P, Taylor PR, Virtamo J, Albanes D (2005) Estimated urine pH and bladder cancer risk in a cohort of male smokers (Finland). Cancer Causes Control 16:1117–1123

Article  PubMed  Google Scholar 

Fischer AH, Wong JYY, Baris D, Koutros S, Karagas MR, Schwenn M et al (2023) Urine pH and risk of bladder cancer in Northern new England. Cancer Epidemiol Biomarkers Prev 32:1323–1327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ide H, Kikuchi E, Ogihara K, Niwa N, Shigeta K, Masuda T et al (2021) Urinary pH is an independent predictor of upper tract recurrence in non-muscle-invasive bladder cancer patients with a smoking history. Sci Rep 11:20675

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han JH, Jeong SH, Yuk HD, Jeong CW, Kwak C, Ku JH (2022) Acidic urine is associated with poor prognosis in patients with bladder cancer undergoing radical cystectomy. Front Oncol 12:964571

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han JH, Jeong SH, Yuk HD, Jeong CW, Kwak C, Ku JH (2022) Acidic urine is associated with poor prognosis of upper tract urothelial carcinoma. Front Oncol 11:817781

Article  PubMed  PubMed Central  Google Scholar 

Erra Díaz F, Dantas E, Geffner J (2018) Unraveling the interplay between extracellular acidosis and immune cells. Mediators Inflamm 2018:1218297

Article  PubMed  PubMed Central  Google Scholar 

Vuillefroy de Silly R, Pericou L, Seijo B, Crespo I, Irving M (2024) Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling. EMBO J 16:1–32

Google Scholar 

Roumiguié M, Kamat AM, Bivalacqua TJ, Lerner SP, Kassouf W, Böhle A et al (2022) International bladder cancer group consensus statement on clinical trial design for patients with bacillus Calmette-Guérin-exposed high-risk non-muscle-invasive bladder cancer. Eur Urol 82:34–46

Article  PubMed  Google Scholar 

Maalouf NM, Cameron MA, Moe OW, Adams-Huet B, Sakhaee K (2007) Low urine pH: a novel feature of the metabolic syndrome. Clin J Am Soc Nephrol 2:883–888

Article  CAS  PubMed  Google Scholar 

Cho YH, Lee SY, Jeong DW, Choi EJ, Nam KJ, Kim YJ et al (2014) The association between a low urine pH and the components of metabolic syndrome in the Korean population: findings based on the 2010 Korea National health and nutrition examination survey. J Res Med Sci 19:599–604

PubMed  PubMed Central  Google Scholar 

Lu Y, Zhang W, Fan S, Liang Z, Li Z, Tian J et al (2021) Metabolic syndrome and risk of upper tract urothelial carcinoma: a case–control study using surveillance, epidemiology and end results-medicare-linked database. Front Oncol 10:613366

Article  PubMed  PubMed Central  Google Scholar 

Nakanishi N, Fukui M, Tanaka M, Toda H, Imai S, Yamazaki M et al (2012) Low urine pH is a predictor of chronic kidney disease. Kidney Blood Press Res 35:77–81

Article  CAS  PubMed  Google Scholar 

Li CE, Chien CS, Chuang YC, Chang YI, Tang HP, Kang CH (2016) Chronic kidney disease as an important risk factor for tumor recurrence, progression, and overall survival in primary non-muscle-invasive bladder cancer. Int Urol Nephrol 48:993–999

Article  PubMed  Google Scholar 

Fujita N, Hatakeyama S, Momota M, Tobisawa Y, Yoneyama T, Yamamoto H et al (2020) Preoperative chronic kidney disease predicts poor prognosis in patients with primary non-muscle-invasive bladder cancer who underwent transurethral resection of the bladder tumor. Urol Oncol 38:684e1–684e8

Article  Google Scholar 

Sylvester RJ (2011) Bacillus Calmette-Guérin treatment of nonmuscle invasive bladder cancer. Int J Urol 18:113–120

Article  CAS  PubMed  Google Scholar 

Gofrit ON, Yutkin V, Shapiro A, Pizov G, Zorn KC, Hidas G et al (2016) The response of variant histology bladder cancer to intravesical immunotherapy compared to conventional cancer. Front Oncol 6:43

Article  PubMed  PubMed Central  Google Scholar 

Ferro M, Barone B, Crocetto F, Lucarelli G, Busetto GM, Del Giudice F et al (2022) Predictive clinico-pathological factors to identify BCG, unresponsive patients, after re-resection for T1 high grade non-muscle invasive bladder cancer. Urol Oncol 40:490e13–e490

Article  Google Scholar 

Fukumoto K, Kikuchi E, Mikami S, Miyajima A, Oya M (2016) Lymphovascular invasion status at transurethral resection of bladder tumors May predict subsequent poor response of T1 tumors to bacillus Calmette-Guérin. BMC Urol 16:5

Article  PubMed  PubMed Central  Google Scholar 

Kamat AM, Li R, O’Donnell MA, Black PC, Roupret M, Catto JW et al (2018) Predicting the response to intravesical bacillus calmette-guérin immunotherapy: are we there yet? A systematic review. Eur Urol 73:738–748

Article  PubMed  Google Scholar 

Alguacil J, Kogevinas M, Silverman DT, Malats N, Real FX, García-Closas M et al (2011) Urinary pH, cigarette smoking and bladder cancer risk. Carcinogenesis 32:843–847

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sylvester RJ, van der MEIJDEN AP, Lamm DL (2002) Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials. J Urol 168:1964–1970

Article  CAS  PubMed  Google Scholar 

Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M et al (2007) Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109:3812–3819

Article  CAS  PubMed  Google Scholar 

Mendler AN, Hu B, Prinz PU, Kreutz M, Gottfried E, Noessner E (2012) Tumor lactic acidosis suppresses CTL function by inhibiting p38 and JNK/c-Jun activation. Int J Cancer 131:633–640