Does CPAP increase or protect against cancer risk in OSA: a systematic review and meta-analysis

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328(17):1230–1235

Article  PubMed  CAS  Google Scholar 

Cheng H, Li D (2021) Investigation into the association between obstructive sleep apnea and incidence of all-type cancers: a systematic review and meta-analysis. Sleep Med

Palamaner Subash Shantha G, Kumar AA, Cheskin LJ, Pancholy SB (2015) Association between sleep-disordered breathing, obstructive sleep apnea, and cancer incidence: a systematic review and meta-analysis. Sleep Med 16 10:1289–1294

Article  Google Scholar 

Momani LA, Alomari M, Kwak HG, Sarmini MT, Kurdi BE, Thota PN et al (2019) 2825 Colorectal Cancer is not associated with obstructive sleep apnea: A Meta-Analysis and systematic review. Am J Gastroenterol

Cheng H, Li D (2021) Investigation into the association between obstructive sleep apnea and incidence of all-type cancers: a systematic review and meta-analysis. Sleep Med 88:274–281

Article  PubMed  Google Scholar 

Cao Y, Ning P, Li Q, Wu S (2022) Cancer and obstructive sleep apnea. Medicine.;101

Sánchez-de-la-Torre M, Cubillos CF, Veatch OJ, García-Río F, Gozal D, Martínez-García MA (2023) Potential pathophysiological pathways in the complex relationships between OSA and Cancer. Cancers.;15

Castrogiovanni A, Modica DM, Amata M, Bonsignore MR (2024) Obstructive sleep apnea and cancer: epidemiology, pathophysiology, and clinical aspects. Minerva Respiratory Med

Kukwa W, Migacz E, Druc K, Grzesiuk E, Czarnecka AM (2015) Obstructive sleep apnea and cancer: effects of intermittent hypoxia? Future Oncol 11 24:3285–3298

Article  Google Scholar 

Marrone O, Bonsignore MR (2020) Obstructive sleep apnea and cancer: a complex relationship. Curr Opin Pulm Med 26:657–667

Article  PubMed  Google Scholar 

Gildeh N, Drakatos P, Higgins SE, Rosenzweig I, Kent BD (2016) Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer. J Thorac Disease 8 9:E901–E17

Article  Google Scholar 

Jordan AS, McSharry DG, Malhotra A (2014) Adult obstructive sleep Apnoea. Lancet 383(9918):736–747

Article  PubMed  Google Scholar 

Gagnadoux F, Bailly S, Schwab RJ (2024) CPAP recall and cancer risk: should we be concerned? Eur Respir J

Brauer PR, Bryson PC, Wu SS, Gau VL, Lamarre ED, Kominsky AH (2022) Cancer risk associated with continuous positive airway pressure: A National study. Laryngoscope 132(11):2270–2274

Article  PubMed  PubMed Central  Google Scholar 

Doherty LS, Kiely JL, Swan V, McNicholas WT (2005) Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome. Chest 127 6:2076–2084

Article  Google Scholar 

Justeau G, Bailly S, Gerves-Pinquie C, Trzepizur W, Meslier N, Goupil F et al (2022) Cancer risk in patients with sleep Apnoea following adherent 5-year CPAP therapy. Eur Respir J.;59(4)

O’Connor-Reina C, Rodriguez Alcala L, Ignacio JM, Garcia-Iriarte MT, Carrasco Llatas M, Casado Morente JC et al (2024) Risk of cancer in patients with sleep apnea: comparison of surgery versus CPAP in a long-term follow-up study. Eur Arch Otorhinolaryngol 281(6):3131–3141

Article  PubMed  Google Scholar 

Kendzerska T, Leung RS, Boulos MI, McIsaac DI, Murray BJ, Bryson GL et al (2021) An association between positive airway pressure device manufacturer and incident cancer?? A secondary data analysis. Am J Respir Crit Care Med 204(12):1484–1488

Article  PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71

Article  PubMed  PubMed Central  Google Scholar 

Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605

Article  PubMed  Google Scholar 

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188

Article  PubMed  CAS  Google Scholar 

Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560

Article  PubMed  PubMed Central  Google Scholar 

Sánchez-de-la-Torre M, Cubillos C, Veatch OJ, Garcia-Rio F, Gozal D, Martinez-Garcia MA (2023) Potential pathophysiological pathways in the complex relationships between OSA and Cancer. Cancers (Basel).;15(4)

Kheirandish-Gozal L, Gozal D (2019) Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines. Int J Mol Sci.;20(3)

Gozal D, Farré R, Nieto FJ (2015) Putative links between sleep apnea and cancer: from hypotheses to evolving evidence. Chest 148(5):1140–1147

Article  PubMed  PubMed Central  Google Scholar 

Arcidiacono B, Iiritano S, Nocera A, Possidente K, Nevolo MT, Ventura V et al (2012) Insulin resistance and Cancer risk: an overview of the pathogenetic mechanisms. J Diabetes Res 2012(1):789174

Google Scholar 

Srivali N, Thongprayoon C, Tangpanithandee S, Cheungpasitporn W, Won C (2023) The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review. Sleep Med 108:55–60

Article  PubMed  Google Scholar 

Xie X, Pan L, Ren D, Du C, Guo Y (2013) Effects of continuous positive airway pressure therapy on systemic inflammation in obstructive sleep apnea: a meta-analysis. Sleep Med 14 11:1139–1150

Article  Google Scholar 

Steiropoulos P, Kotsianidis I, Nena E, Tsara V, Gounari E, Hatzizisi O et al (2009) Long-term effect of continuous positive airway pressure therapy on inflammation markers of patients with obstructive sleep apnea syndrome. Sleep 32(4):537–543

Article  PubMed  PubMed Central  Google Scholar 

Scully T, Ettela A, Leroith D, Gallagher EJ, Obesity (2021) Type 2 diabetes, and Cancer risk. Front Oncol.;10

Comments (0)

No login
gif