Bengoechea JA, Sa PJ. Klebsiella pneumoniae infection biology: living to counteract host defences. FEMS Microbiol Rev. 2018;43(2):123–44.

Article  PubMed Central  Google Scholar 

Chen J, Ma H, Huang X, Cui Y, Peng W, Zhu F, et al. Risk factors and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary-care hospital in China: an eight-year retrospective study. Antimicrob Resist Infect Control. 2022;11(1):161.

Article  PubMed  PubMed Central  Google Scholar 

Balkhair A, Al-Muharrmi Z, Al’Adawi B, Al Busaidi I, Taher HB, Al-Siyabi T, et al. Prevalence and 30-day all-cause mortality of carbapenem-and colistin-resistant bacteraemia caused by Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae: description of a decade-long trend. Int J Infect Dis. 2019;85:10–5.

Article  CAS  PubMed  Google Scholar 

Wang N, Zhan M, Liu J, Wang Y, Hou Y, Li C, et al. Prevalence of carbapenem-resistant Klebsiella pneumoniae infection in a northern province in China: Clinical characteristics, drug resistance, and geographic distribution. Infect Drug Resist. 2022;15:569–79.

Article  PubMed  PubMed Central  Google Scholar 

Kotb S, Lyman M, Ismail G, Abd El Fattah M, Girgis SA, Etman A, et al. Epidemiology of carbapenem-resistant Enterobacteriaceae in Egyptian intensive care units using national healthcare-associated infections surveillance data, 2011–2017. Antimicrob Resist Infect Control. 2020. https://doi.org/10.1186/s13756-019-0639-7.

Article  PubMed  PubMed Central  Google Scholar 

Lin X-c, Li C-l, Zhang S-y, Yang X-f, Jiang M. The global and regional prevalence of hospital-acquired carbapenem-resistant Klebsiella pneumoniae infection: a systematic review and meta-analysis. Open Forum Infect Dis. 2023. https://doi.org/10.1093/ofid/ofad649.

Article  PubMed  PubMed Central  Google Scholar 

Navon-Venezia S, Kondratyeva K, Carattoli A. Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance. FEMS Microbiol Rev. 2017;41(3):252–75.

Article  CAS  PubMed  Google Scholar 

Biswas S, Brunel JM, Dubus JC, Reynaud-Gaubert M, Rolain JM. Colistin: an update on the antibiotic of the 21st century. Expert Rev Anti Infect Ther. 2012;10(8):917–34.

Article  CAS  PubMed  Google Scholar 

El-Sayed Ahmed MAE, Zhong LL, Shen C, Yang Y, Doi Y, Tian GB. Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019). Emerg Microbes Infect. 2020;9(1):868–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ah YM, Kim AJ, Lee JY. Colistin resistance in Klebsiella pneumoniae. Int J Antimicrob Agents. 2014;44(1):8–15.

Article  CAS  PubMed  Google Scholar 

Poirel L, Jayol A, Nordmann P. Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clin Microbiol Rev. 2017;30(2):557–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeannot K, Bolard A, Plesiat P. Resistance to polymyxins in Gram-negative organisms. Int J Antimicrob Agents. 2017;49(5):526–35.

Article  CAS  PubMed  Google Scholar 

Yusof NY, Norazzman NII, Hakim S, Azlan MM, Anthony AA, Mustafa FH, et al. Prevalence of mutated colistin-resistant Klebsiella pneumoniae: a systematic review and meta-analysis. Trop Med Infect Dis. 2022;7(12):414.

Article  PubMed  PubMed Central  Google Scholar 

Binsker U, Kasbohrer A, Hammerl JA. Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis. FEMS Microbiol Rev. 2022. https://doi.org/10.1093/femsre/fuab049.

Article  PubMed  Google Scholar 

Wang C, Feng Y, Liu L, Wei L, Kang M, Zong Z. Identification of novel mobile colistin resistance gene mcr-10. Emerg Microbes Infect. 2020;9(1):508–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sameni F, Ghazi M, Dadashi M, Bostanshirin N, Al-Dahmoshi HOM, Khosravi-Dehaghi N, et al. Global distribution, genotypes and prevalent sequence types of colistin-resistant Klebsiella pneumoniae isolated from clinical samples. A systematic review Gene Rep. 2022;28:101635.

CAS  Google Scholar 

Phetburom N, Boueroy P, Chopjitt P, Hatrongjit R, Akeda Y, Hamada S, et al. Klebsiella pneumoniae complex harboring mcr-1, mcr-7, and mcr-8 isolates from slaughtered pigs in Thailand. Microorganisms. 2021;9(12):2436.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brennan-Krohn T, Pironti A, Kirby JE. Synergistic activity of colistin-containing combinations against colistin-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2018. https://doi.org/10.1128/AAC.00873-18.

Article  PubMed  PubMed Central  Google Scholar 

Karakonstantis S, Kritsotakis EI, Gikas A. Pandrug-resistant Gram-negative bacteria: a systematic review of current epidemiology, prognosis and treatment options. J Antimicrob Chemother. 2019;75(2):271–82.

Google Scholar 

Doern CD. When does 2 plus 2 equal 5? A review of antimicrobial synergy testing. J Clin Microbiol. 2014;52(12):4124–8.

Article  PubMed  PubMed Central  Google Scholar 

MacNair CR, Stokes JM, Carfrae LA, Fiebig-Comyn AA, Coombes BK, Mulvey MR, et al. Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics. Nat Commun. 2018;9(1):458.

Article  PubMed  PubMed Central  Google Scholar 

Brennan-Krohn T, Truelson KA, Smith KP, Kirby JE. Screening for synergistic activity of antimicrobial combinations against carbapenem-resistant Enterobacteriaceae using inkjet printer-based technology. J Antimicrob Chemother. 2017;72(10):2775–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kofteridis DP, Andrianaki AM, Maraki S, Mathioudaki A, Plataki M, Alexopoulou C, et al. Treatment pattern, prognostic factors, and outcome in patients with infection due to pan-drug-resistant Gram-negative bacteria. Eur J Clin Microbiol Infect Dis. 2020;39(5):965–70.

Article  CAS  PubMed  Google Scholar 

Bae S, Kim M-C, Park S-J, Kim HS, Sung H, Kim M-N, et al. In vitro synergistic activity of antimicrobial agents in combination against clinical isolates of colistin-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2016;60(11):6774–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Niu H, Wang R, Cai Y. Safety and efficacy of colistin alone or in combination in adults with Acinetobacter baumannii infection: a systematic review and meta-analysis. Int J Antimicrob Agents. 2019;53(4):383–400.

Article  CAS  PubMed  Google Scholar 

Ontong JC, Ozioma NF, Voravuthikunchai SP, Chusri S. Synergistic antibacterial effects of colistin in combination with aminoglycoside, carbapenems, cephalosporins, fluoroquinolones, tetracyclines, fosfomycin, and piperacillin on multidrug resistant Klebsiella pneumoniae isolates. PLoS ONE. 2021;16(1): e0244673.

Article  CAS  PubMed  PubMed Central  Google Scholar 

CLSI. Performance standards for antimicrobial susceptibility testing, CLSI supplement M100. 31st ed. Wayne: Clinical and Laboratory Standards Institute; 2021.

Google Scholar 

FDA Database. https://www.fda.gov/drugs/development-resources/tigecycline-injection-products. Accessed 5 Jul 2021.

Derakhshan S, Sattari M, Bigdeli M. Effect of subinhibitory concentrations of cumin (Cuminum cyminum L.) seed essential oil and alcoholic extract on the morphology, capsule expression and urease activity of Klebsiella pneumoniae. Int J Antimicrob Agents. 2008;32(5):432–6.

Article  CAS  PubMed  Google Scholar 

Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med. 2004;199(5):697–705.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abebe GM. Detection of biofilm formation and antibiotic resistance in Klebsiella oxytoca and Klebsiella pneumoniae from animal origin foods. Int J Microbiol Biotechnol. 2020;5(3):120