(Auto‑)Immunität bei fokaler Epilepsie: Mechanismen (auto‑)immun-inflammatorischer epileptogener Neurodegeneration

Aarts JH, Binnie CD, Smit AM et al (1984) Selective cognitive impairment during focal and generalized epileptiform EEG activity. Brain 107(1):293–308

Article  PubMed  Google Scholar 

Al-Diwani A, Theorell J, Damato V et al (2022) Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis. Brain 145:2742–2754

Article  PubMed Central  PubMed  Google Scholar 

Alberti P, Handel AE (2021) The contribution of thymic tolerance to central nervous system autoimmunity. Semin Immunopathol 43:135–157

Article  CAS  PubMed  Google Scholar 

Bauer J, Becker AJ, Elyaman W et al (2017) Innate and adaptive immunity in human epilepsies. Epilepsia 58(3):57–68

Article  CAS  PubMed Central  PubMed  Google Scholar 

Bauer J, Becker AJ, Elyaman W et al (2017) Innate and adaptive immunity in human epilepsies. Epilepsia 58(3):57–68

Article  CAS  PubMed Central  PubMed  Google Scholar 

Bien CG, Schulze-Bonhage A, Deckert M et al (2000) Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy. Neurology 55:1823–1828

Article  CAS  PubMed  Google Scholar 

Bien CG, Urbach H, Schramm J et al (2007) Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy. Neurology 69:1236–1244

Article  CAS  PubMed  Google Scholar 

Bien CG, Vincent A, Barnett MH et al (2012) Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain 135:1622–1638

Article  PubMed  Google Scholar 

Blumcke I, Spreafico R, Haaker G et al (2017) Histopathological findings in brain tissue obtained during epilepsy surgery. N Engl J Med 377:1648–1656

Article  PubMed  Google Scholar 

Brandle SM, Cerina M, Weber S et al (2021) Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.1916337118

Article  PubMed Central  PubMed  Google Scholar 

Carreno M, Bien CG, Asadi-Pooya AA et al (2017) Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies. Epilepsy Res 129:101–105

Article  PubMed  Google Scholar 

Chuquisana O, Strippel C, Gross CC et al (2022) Antibody response to herpes simplex virus‑1 is increased in autoimmune encephalitis. Eur J Immunol 52:1198–1200

Article  CAS  PubMed  Google Scholar 

Chuquisana O, Strippel C, Troscher AM et al (2022) Complement activation contributes to GAD antibody-associated encephalitis. Acta Neuropathol 144:381–383

Article  CAS  PubMed Central  PubMed  Google Scholar 

Cserr HF, Harling-Berg CJ, Knopf PM (1992) Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 2:269–276

Article  CAS  PubMed  Google Scholar 

Dalmau J, Gleichman AJ, Hughes EG et al (2008) Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7:1091–1098

Article  CAS  PubMed Central  PubMed  Google Scholar 

Dalmau J, Graus F (2018) Antibody-mediated encephalitis. N Engl J Med 378:840–851

Article  PubMed  Google Scholar 

Dalmau J, Rosenfeld MR (2008) Paraneoplastic syndromes of the CNS. Lancet Neurol 7:327–340

Article  PubMed Central  PubMed  Google Scholar 

Daneman R, Engelhardt B (2017) Brain barriers in health and disease. Neurobiol Dis 107:1–3

Article  PubMed  Google Scholar 

Deluca I, Blachere NE, Santomasso B et al (2009) Tolerance to the neuron-specific paraneoplastic HuD antigen. PLoS ONE 4:e5739

Article  PubMed Central  PubMed  Google Scholar 

Di Liberto G, Pantelyushin S, Kreutzfeldt M et al (2018) Neurons under T cell attack coordinate phagocyte-mediated synaptic stripping. Cell 175:458–471 e419

Article  CAS  PubMed  Google Scholar 

Di Sapia R, Zimmer TS, Kebede V et al (2021) CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy. Neurobiol Dis 158:105468

Article  CAS  PubMed  Google Scholar 

Dik A, Widman G, Schulte-Mecklenbeck A et al (2021) Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis. Ann Clin Transl Neurol 8:2289–2301

Article  CAS  PubMed Central  PubMed  Google Scholar 

Gales JM, Prayson RA (2017) Chronic inflammation in refractory hippocampal sclerosis-related temporal lobe epilepsy. Ann Diagn Pathol 30:12–16

Article  PubMed  Google Scholar 

Geis C, Planaguma J, Carreno M et al (2019) Autoimmune seizures and epilepsy. J Clin Invest 129:926–940

Article  PubMed Central  PubMed  Google Scholar 

Gelinas JN, Khodagholy D, Thesen T et al (2016) Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med 22:641–648

Article  CAS  PubMed Central  PubMed  Google Scholar 

Giometto B, Nicolao P, Macucci M et al (1998) Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies. Lancet 352:457

Article  CAS  PubMed  Google Scholar 

Golombeck KS, Bonte K, Monig C et al (2016) Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis. Neurol Neuroimmunol Neuroinflamm 3:e232

Article  PubMed Central  PubMed  Google Scholar 

Graus F, Saiz A, Dalmau J (2020) GAD antibodies in neurological disorders – insights and challenges. Nat Rev Neurol 16:353–365

Article  CAS  PubMed  Google Scholar 

Hansen N, Ernst L, Ruber T et al (2018) Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy. Epilepsy Behav 79:93–99

Article  PubMed  Google Scholar 

Henin S, Shankar A, Borges H et al (2021) Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing. Brain 144:1590–1602

Article  PubMed Central  PubMed  Google Scholar 

Ince-Dunn G, Okano HJ, Jensen KB et al (2012) Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron 75:1067–1080

Article  CAS  PubMed Central  PubMed  Google Scholar 

Iyer A, Zurolo E, Spliet WG et al (2010) Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias. Epilepsia 51:1763–1773

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