Arai F, Hirao A, Ohmura M et al (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118:149–161. https://doi.org/10.1016/j.cell.2004.07.004
Article CAS PubMed Google Scholar
Asfaha S, Hayakawa Y, Muley A et al (2015) Krt19(+)/Lgr5(-) cells are radioresistant cancer-initiating stem cells in the colon and intestine. Cell Stem Cell 16:627–638. https://doi.org/10.1016/j.stem.2015.04.013
Article CAS PubMed PubMed Central Google Scholar
Ayyaz A, Kumar S, Sangiorgi B et al (2019) Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature 569:121–125. https://doi.org/10.1038/s41586-019-1154-y
Article CAS PubMed Google Scholar
Barker N, van Es JH, Kuipers J et al (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449:1003–1007. https://doi.org/10.1038/nature06196
Article CAS PubMed Google Scholar
Barriga FM, Montagni E, Mana M et al (2017) Mex3a marks a slowly dividing subpopulation of Lgr5+ intestinal stem cells. Cell Stem Cell 20:801-816.e7. https://doi.org/10.1016/j.stem.2017.02.007
Article CAS PubMed PubMed Central Google Scholar
Cairnie AB, Lamerton LF, Steel GG (1965) Cell proliferation studies in the intestinal epithelium of the rat. I. Determination of the kinetic parameters. Exp Cell Res 39:528–538. https://doi.org/10.1016/0014-4827(65)90055-8
Article CAS PubMed Google Scholar
Cairns J (2002) Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc Natl Acad Sci U S A 99:10567–10570. https://doi.org/10.1073/pnas.162369899
Article CAS PubMed PubMed Central Google Scholar
Clevers H (2016) Modeling development and disease with organoids. Cell 165:1586–1597. https://doi.org/10.1016/j.cell.2016.05.082
Article CAS PubMed Google Scholar
Cotsarelis G, Cheng SZ, Dong G et al (1989) Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57:201–209. https://doi.org/10.1016/0092-8674(89)90958-6
Article CAS PubMed Google Scholar
Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329–1337. https://doi.org/10.1016/0092-8674(90)90696-c
Article CAS PubMed Google Scholar
Foudi A, Hochedlinger K, Van Buren D et al (2009) Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol 27:84–90. https://doi.org/10.1038/nbt.1517
Article CAS PubMed Google Scholar
Greco V, Chen T, Rendl M et al (2009) A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4:155–169. https://doi.org/10.1016/j.stem.2008.12.009
Article CAS PubMed PubMed Central Google Scholar
Haug JS, He XC, Grindley JC et al (2008) N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells. Cell Stem Cell 2:367–379. https://doi.org/10.1016/j.stem.2008.01.017
Article CAS PubMed Google Scholar
Hughes KR, Gândara RMC, Javkar T et al (2012) Heterogeneity in histone 2B-green fluorescent protein-retaining putative small intestinal stem cells at cell position 4 and their absence in the colon. Am J Physiol Gastrointest Liver Physiol 303:G1188–G1201. https://doi.org/10.1152/ajpgi.00080.2012
Article CAS PubMed Google Scholar
Ireland H, Houghton C, Howard L, Winton DJ (2005) Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine. Dev Dyn 233:1332–1336. https://doi.org/10.1002/dvdy.20446
Article CAS PubMed Google Scholar
Itzkovitz S, Lyubimova A, Blat IC et al (2011) Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol 14:106–114. https://doi.org/10.1038/ncb2384
Article CAS PubMed PubMed Central Google Scholar
Li L, Clevers H (2010) Coexistence of quiescent and active adult stem cells in mammals. Science 327:542–545. https://doi.org/10.1126/science.1180794
Article CAS PubMed PubMed Central Google Scholar
Meran L, Massie I, Campinoti S et al (2020) Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure. Nat Med 26:1593–1601. https://doi.org/10.1038/s41591-020-1024-z
Article CAS PubMed Google Scholar
Metcalfe C, Kljavin NM, Ybarra R, de Sauvage FJ (2013) Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell 14:149–159. https://doi.org/10.1016/j.stem.2013.11.008
Article CAS PubMed Google Scholar
Montgomery RK, Carlone DL, Richmond CA et al (2010) Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A 108:179–184. https://doi.org/10.1073/pnas.1013004108
Article PubMed PubMed Central Google Scholar
Muñoz J, Stange DE, Schepers AG et al (2012) The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent “+4” cell markers. EMBO J 31:3079–3091. https://doi.org/10.1038/emboj.2012.166
Article CAS PubMed PubMed Central Google Scholar
Nanki K, Fujii M, Shimokawa M et al (2020) Somatic inflammatory gene mutations in human ulcerative colitis epithelium. Nature 577:254–259. https://doi.org/10.1038/s41586-019-1844-5
Article CAS PubMed Google Scholar
Nikolaev M, Mitrofanova O, Broguiere N et al (2020) Homeostatic mini-intestines through scaffold-guided organoid morphogenesis. Nature 585(7826):574–578. https://doi.org/10.1038/s41586-020-2724-8
Article CAS PubMed Google Scholar
Oszvald Á, Szvicsek Z, Sándor GO et al (2020) Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche. Stem Cells 38:291–300. https://doi.org/10.1002/stem.3113
Article CAS PubMed Google Scholar
Potten CS, Booth C (2002) Keratinocyte stem cells: a commentary. J Invest Dermatol 119:888–899. https://doi.org/10.1046/j.1523-1747.2002.00020.x
Article CAS PubMed Google Scholar
Potten CS, Kovacs L, Hamilton E (1974) Continuous labelinglabelling studies on mouse skin and intestine. Cell Tissue Kinet 7:271–283. https://doi.org/10.1111/j.1365-2184.1974.tb00907.x
Article CAS PubMed Google Scholar
Potten CS, Hume WJ, Reid P, Cairns J (1978) The segregation of DNA in epithelial stem cells. Cell 15:899–906. https://doi.org/10.1016/0092-8674(78)90274-x
Comments (0)