Therapeutic Effect of Melatonin on CCl4-Induced Fibrotic Liver Model by Modulating Oxidative Stress, Inflammation, and TGF-β1 Signaling Pathway in Pinealectomized Rats

Tennant, B.C., and S.A. Center. 2008. Hepatic function. Clinical biochemistry of domestic animals 6: 379–412.

Article  Google Scholar 

Muriel, P. 2007. Some experimental models of liver damage. Hepatotoxicity: from Genomics to in Vitro and in Vivo Models. 119–137. https://doi.org/10.1002/9780470516751.ch6

Fathy, M., E.M. Khalifa, and M.A. Fawzy. 2019. Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats. Life sciences 216: 207–214.

Article  CAS  PubMed  Google Scholar 

Wang, H., W. Wei, N.-P. Wang, S.-Y. Gui, L. Wu, W.-Y. Sun, and S.-Y. Xu. 2005. Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. Life sciences 77: 1902–1915.

Article  CAS  PubMed  Google Scholar 

Recknagel, R.O., E.A. Glende Jr., J.A. Dolak, and R.L. Waller. 1989. Mechanisms of carbon tetrachloride toxicity. Pharmacology & therapeutics 43: 139–154.

Article  CAS  Google Scholar 

Cornelli, U. 2009. Antioxidant use in nutraceuticals. Clinics in dermatology 27: 175–194.

Article  PubMed  Google Scholar 

Halliwell, B. 1991. Reactive oxygen species in living systems: Source, biochemistry, and role in human disease. The American journal of medicine 91: S14–S22.

Article  Google Scholar 

Dunning, S., A. ur Rehman, M.H. Tiebosch, R.A. Hannivoort, F.W. Haijer, J. Woudenberg, F.A. van den Heuvel, M. Buist-Homan, K.N. Faber, and H. Moshage. 2013. Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death. Molecular Basis of Disease 1832: 2027–2034. https://doi.org/10.1016/j.bbadis.2013.07.008.

Article  CAS  Google Scholar 

Najeeb, S., Z. Khurshid, S. Zohaib, and M.S. Zafar. 2016. Therapeutic potential of melatonin in oral medicine and periodontology. The Kaohsiung journal of medical sciences 32: 391–396.

Article  PubMed  Google Scholar 

Meng, X., Y. Li, S. Li, Y. Zhou, R.-Y. Gan, D.-P. Xu, and H.-B. Li. 2017. Dietary sources and bioactivities of melatonin. Nutrients 9: 367.

Article  PubMed  PubMed Central  Google Scholar 

Pereira, N., M.F. Naufel, E.B. Ribeiro, S. Tufik, and H. Hachul. 2020. Influence of dietary sources of melatonin on sleep quality: A review. Journal of food science 85: 5–13.

Article  CAS  PubMed  Google Scholar 

Esteban-Zubero, E., L. López-Pingarrón, M.A. Alatorre-Jiménez, P. Ochoa-Moneo, C. Buisac-Ramon, M. Rivas-Jimenez, S. Castan-Ruiz, A. Antonanzas-Lombarte, D.-X. Tan, and J.J. García. 2017. Melatonin’s role as a co-adjuvant treatment in colonic diseases: A review. Life sciences 170: 72–81.

Article  CAS  PubMed  Google Scholar 

Rezzani, R., L. Rodella, G. Favero, G. Damiani, C. Paganelli, and R. Reiter. 2014. Attenuation of ultraviolet A-induced alterations in NIH3T3 dermal fibroblasts by melatonin. British Journal of Dermatology 170: 382–391.

Article  CAS  PubMed  Google Scholar 

Cosgun, B.E., M.E. Erdemli, M. Gul, S. Gul, H.G. Bag, Z. Erdemli, and E. Altinoz. 2019. Crocin (active constituent of saffron) improves CCl4-induced liver damage by modulating oxidative stress in rats. Turkish Journal of Biochemistry 44: 370–378.

Article  CAS  Google Scholar 

Yu, X., L. Huang, C. You, and L. Huang. 2021. Hepatoprotective effects of polysaccharide from Anoectochilus roxburghii (Wall.) Lindl. on rat liver injury induced by CCl4. Drug Design, Development and Therapy 15: 2885–2897.

Article  PubMed  PubMed Central  Google Scholar 

Kim, C.-Y., M.-J. Lee, S.M. Lee, W.C. Lee, and J.S. Kim. 1998. Effect of melatonin on cadmium-induced hepatotoxicity in male Sprague-Dawley rats. The Tohoku Journal of Experimental Medicine 186: 205–213.

Article  CAS  PubMed  Google Scholar 

Keelo, R.M.A.H., H. Elbe, Y. Bicer, G. Yigitturk, O. Koca, M. Karayakali, D. Acar, and E. Altinoz. 2022. Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats. Chemico-Biological Interactions 351: 109733.

Article  Google Scholar 

Ohkawa, H., N. Ohishi, and K. Yagi. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical biochemistry 95: 351–358.

Article  CAS  PubMed  Google Scholar 

Ellman, G.L. 1959. Tissue sulfhydryl groups. Archives of biochemistry and biophysics 82: 70–77.

Article  CAS  PubMed  Google Scholar 

Sun, Y., L.W. Oberley, and Y. Li. 1988. A simple method for clinical assay of superoxide dismutase. Clinical chemistry 34: 497–500.

Article  CAS  PubMed  Google Scholar 

Aebi, H. 1984. [13] Catalase in vitro. Methods in enzymology, Elsevier, 121–126. https://doi.org/10.1016/S0076-6879(84)05016-3

Lowry, O.H. 1951. Measurement with the folin phenol reagent. J Biol Chem 193: 265–275.

Article  CAS  PubMed  Google Scholar 

Erel, O. 2005. A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry 38: 1103–1111.

Article  CAS  PubMed  Google Scholar 

Erel, O. 2004. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical biochemistry 37: 277–285.

Article  CAS  PubMed  Google Scholar 

Erel, O. 2004. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical biochemistry 37: 112–119.

Article  CAS  PubMed  Google Scholar 

Ozturk, I., H. Elbe, Y. Bicer, M. Karayakali, M.O. Onal, and E. Altinoz. 2023. Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation. Food and Chemical Toxicology 174: 113658.

Article  CAS  PubMed  Google Scholar 

Yan, J.-K., C. Wang, T.-T. Chen, J. Zhu, X. Chen, L. Li, X. Liu, H. Zhang, and L. Li. 2023. A pectic polysaccharide from fresh okra (Abelmoschus esculentus L.) beneficially ameliorates CCl4-induced acute liver injury in mice by antioxidation, inhibition of inflammation and modulation of gut microbiota. Food and Chemical Toxicology 171: 113551.

Article  CAS  PubMed  Google Scholar 

Algefare, A.I., M. Alfwuaires, A.C. Famurewa, H. Elsawy, and A. Sedky. 2024. Geraniol prevents CCl4-induced hepatotoxicity via suppression of hepatic oxidative stress, pro-inflammation and apoptosis in rats. Toxicology Reports 12: 128–134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El-Kot, S.M., W. Wanas, A.M. Hafez, N.A. Mahmoud, A.M. Tolba, A.H. Younis, G.E. Sayed, and H.E. Abdelwahab. 2023. Effect of silymarin on the relative gene expressions of some inflammatory cytokines in the liver of CCl4-intoxicated male rats. Scientific Reports 13: 15245.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ning, Q.-J., S.-W. Qin, and C.-S. Xu. 2006. Expression patterns and action analysis of genes associated with drug-induced liver diseases during rat liver regeneration. World Journal of Gastroenterology: WJG 12: 6966.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozturk, F., M. Ucar, I.C. Ozturk, N. Vardi, and K. Batcioglu. 2003. Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology 62: 353–356.

Article  PubMed  Google Scholar 

El-Meligy, R.M., M.E. Zain, and F.A. Ahmed. 2014. Protective role of Cynanchum acutum L. extracts on carbon tetrachloride-induced hepatotoxicity in rat. Int J Chem Appl Biol Sci 1: 9.

Article  Google Scholar 

Zhao, Y., M. Zhao, Z. Wang, C. Zhao, Y. Zhang, and M. Wang. 2024. Danggui Shaoyao San: Chemical characterization and inhibition of oxidative stress and inflammation to treat CCl4-induced hepatic fibrosis. Journal of Ethnopharmacology 318: 116870.

Article  CAS 

Comments (0)

No login
gif