Levy, M.L., L.B. Bacharier, E. Bateman, L.P. Boulet, C. Brightling, R. Buhl, et al. 2023. Key recommendations for primary care from the 2022 global initiative for asthma (GINA) update. NPJ Primary Care Respiratory Medicine 33: 7.
Article PubMed PubMed Central Google Scholar
Bener, A., M. Ehlayel, and A. Sabbah. 2007. The pattern and genetics of pediatric extrinsic asthma risk factors in polluted environment. European Annals of Allergy and Clinical Immunology 39: 58–63.
Kuruvilla, M.E., F.E.-H. Lee, and G.B. Lee. 2019. Understanding asthma phenotypes, Endotypes, and mechanisms of disease. Clinical Reviews in Allergy & Immunology 56: 219–233.
Kay, A.B., E.W. Gelfand, L.J. Smith, and D. Tashkin. 2002. Natural history of asthma from childhood to adulthood. Clinical & Experimental Allergy Reviews 2: 117–127.
Lambrecht, B.N., H. Hammad, and J.V. Fahy. 2019. The cytokines of asthma. Immunity 50: 975–991.
Article CAS PubMed Google Scholar
Salvermoser, M., K. Zeber, A. Boeck, E. Klucker, and B. Schaub. 2021. Childhood asthma: Novel endotyping by cytokines, validated through sensitization profiles and clinical characteristics. Clinical and Experimental Allergy 51: 654–665.
Article CAS PubMed Google Scholar
Lee, J.H., Y.T. Lin, A.L. Chu, S.Y. Hsiao, K.Y. Chang, Y.H. Yang, et al. 2022. Predictive characteristics to discriminate the longitudinal outcomes of childhood asthma: A retrospective program-based study. Pediatric Research 92: 1357–1363.
Article CAS PubMed Google Scholar
Brasier, A.R., and N.N. Jarjour. 2023. Precision approaches to heterogeneity in asthma. Springer.
McIntyre, A.P., and R.K. Viswanathan. 2023. Phenotypes and Endotypes in asthma. Advances in Experimental Medicine and Biology 1426: 119–142.
Article CAS PubMed Google Scholar
Lameire, S., and H. Hammad. 2023. Lung epithelial cells: Upstream targets in type 2-high asthma. European Journal of Immunology 53: e2250106.
Lee, J.H., L.C. Wang, Y.T. Lin, Y.H. Yang, H.H. Yu, Y.C. Hu, et al. 2023. Differentially expressed microRNAs in peripheral blood cell are associated with downregulated expression of IgE in nonallergic childhood asthma. Scientific Reports 13: 6381.
Article CAS PubMed PubMed Central Google Scholar
Kyriakopoulos, C., A. Gogali, K. Bartziokas, and K. Kostikas. 2021. Identification and treatment of T2-low asthma in the era of biologics. ERJ Open Research 7.
Hudey, S.N., D.K. Ledford, and J.C. Cardet. 2020. Mechanisms of non-type 2 asthma. Current Opinion in Immunology 66: 123–128.
Article CAS PubMed PubMed Central Google Scholar
Hammad, H., and B.N. Lambrecht. 2021. The basic immunology of asthma. Cell 184: 1469–1485.
Article CAS PubMed Google Scholar
Peters, M.C., L. Ringel, N. Dyjack, R. Herrin, P.G. Woodruff, C. Rios, et al. 2019. A transcriptomic method to determine airway immune dysfunction in T2-high and T2-low asthma. American Journal of Respiratory and Critical Care Medicine 199: 465–477.
Article CAS PubMed PubMed Central Google Scholar
Fitzpatrick, A.M., B.E. Chipps, F. Holguin, and P.G. Woodruff. 2020. T2-"low" asthma: Overview and management strategies. The Journal of Allergy and Clinical Immunology. In Practice 8: 452–463.
Sicherer, S.H., R.A. Wood, American Academy of Pediatrics Section On Allergy And Immunology, S.H. Sicherer, S. Abramson, et al. 2012. Allergy testing in childhood: Using allergen-specific IgE tests. Pediatrics 129: 193–197.
Viinanen, A., J. Aakko, M.I. Lassenius, G. Telg, K. Nieminen, S. Kaijala, et al. 2023. Type 2 low biomarker stability and exacerbations in severe uncontrolled asthma. Biomolecules 13.
Peters, S.P. 2014. Asthma phenotypes: Nonallergic (intrinsic) asthma. The Journal of Allergy and Clinical Immunology. In Practice 2: 650–652.
Conrad, L.A., M.D. Cabana, and D. Rastogi. 2021. Defining pediatric asthma: Phenotypes to endotypes and beyond. Pediatric Research 90: 45–51.
Schuierer, S., W. Carbone, J. Knehr, V. Petitjean, A. Fernandez, M. Sultan, et al. 2017. A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples. BMC Genomics 18: 442.
Article PubMed PubMed Central Google Scholar
Shin, H., C.P. Shannon, N. Fishbane, J. Ruan, M. Zhou, R. Balshaw, et al. 2014. Variation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion. PLoS One 9: e91041.
Article PubMed PubMed Central Google Scholar
Harrington, C.A., S.S. Fei, J. Minnier, L. Carbone, R. Searles, B.A. Davis, et al. 2020. RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-zero library method. Scientific Reports 10: 6271.
Article CAS PubMed PubMed Central Google Scholar
Love, M.I., W. Huber, and S. Anders. 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology 15: 550.
Article PubMed PubMed Central Google Scholar
2008. The gene ontology project in 2008. Nucleic Acids Research 36: D440–D444.
Yu, G., L.G. Wang, Y. Han, and Q.Y. He. 2012. clusterProfiler: An R package for comparing biological themes among gene clusters. Omics 16: 284–287.
Article CAS PubMed PubMed Central Google Scholar
Kanehisa, M., M. Araki, S. Goto, M. Hattori, M. Hirakawa, M. Itoh, et al. 2008. KEGG for linking genomes to life and the environment. Nucleic Acids Research 36: D480–D484.
Article CAS PubMed Google Scholar
Szklarczyk, D., A.L. Gable, D. Lyon, A. Junge, S. Wyder, J. Huerta-Cepas, et al. 2019. STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Research 47: D607–d613.
Article CAS PubMed Google Scholar
Subramanian, A., P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, et al. 2005. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America 102: 15545–15550.
Article CAS PubMed PubMed Central Google Scholar
Altman, M.C., A. Calatroni, S. Ramratnam, D.J. Jackson, S. Presnell, M.G. Rosasco, et al. 2021. Endotype of allergic asthma with airway obstruction in urban children. The Journal of Allergy and Clinical Immunology 148: 1198–1209.
Article CAS PubMed Google Scholar
Elbashir, M.K., M. Mohammed, H. Mwambi, and B. Omolo. 2023. Identification of hub genes associated with breast Cancer using integrated gene expression data with protein-protein interaction network. Applied Sciences 13: 2403.
Karbalaei, R., M. Piran, M. Rezaei-Tavirani, H. Asadzadeh-Aghdaei, and M.H. Heidari. 2017. A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information. Gastroenterology and Hepatology from Bed to Bench 10: 194–201.
PubMed PubMed Central Google Scholar
Zhou, G., Q. Zeng, W. Wei, H. Teng, C. Liu, Z. Zhou, et al. 2022. A pilot study of differential gene expressions in patients with cough variant asthma and classic bronchial asthma. The Journal of Asthma 59: 1070–1078.
Article CAS PubMed Google Scholar
Mak, J.C., H.C. Leung, S.P. Ho, B.K. Law, W.K. Lam, K.W. Tsang, et al. 2004. Systemic oxidative and antioxidative status in Chinese patients with asthma. The Journal of Allergy and Clinical Immunology 114: 260–264.
Article CAS PubMed Google Scholar
Agamah, F.E., D. Damena, M. Skelton, A. Ghansah, G.K. Mazandu, and E.R. Chimusa. 2021. Network-driven analysis of human-plasmodium falciparum interactome: Processes for malaria drug discovery and extracting in silico targets. Malaria Journal 20: 421.
Comments (0)