A dose-ranging study of the physiological and self-reported effects of repeated, rapid infusion of remifentanil in people with opioid use disorder and physical dependence on fentanyl

American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edition. American Psychiatric Association: Washington, DC

Antoine D, Huhn AS, Strain EC, Turner G, Jardot J, Hammond AS, Dunn KE (2021) Method for successfully inducting individuals who use illicit fentanyl onto buprenorphine/naloxone. Am J Addict 30:83–87

Article  PubMed  Google Scholar 

Banks ML, Negus SS (2017) Insights from preclinical choice models on treating drug addiction. Trends Pharmacol Sci 38:181–194

Article  CAS  PubMed  Google Scholar 

Beylon GJ, Kaplan HL, Somer G, Busto UE, Sellers EM (2000) Comparative abuse liability of intravenously administered remifentanil and fentanyl. J Clin Pharmacol 20:597–606

Google Scholar 

Bodner RJ (2008) Endogenous opiates and behavior: 2007. Peptides 29:2292–2375

Article  Google Scholar 

Center for Disease Control and Prevention (2022) Provisional Drug Overdose Death Counts. Accessed at https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm

Chow JJ, Beckmann JS (2021) Remifentanil-food choice follows predictions of relative subjective value. Drug Alcohol Depend 218:108369

Article  CAS  PubMed  Google Scholar 

Ciccarone D (2021) The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis. Curr Opin Psychiatry 34:344–350

Article  PubMed  PubMed Central  Google Scholar 

Cooper ZD, Truong NT, Shi YG, Woods JH (2008) Morphine deprivation increases self-administration of the fast and short-acting mu-opioid agonist remifentanil in the rat. J Pharmacol Exp Ther 326:920–929

Article  CAS  PubMed  Google Scholar 

Duthie DJ, Stevens JJ, Doyle AR, Baddoo HH, Gupta SK, Muir KT, Kirkham AJ (1997) Remifentanil and pulmonary extraction during and after cardiac anesthesia. Anesth Analg 84:740–744

Article  CAS  PubMed  Google Scholar 

Foltin RW, Haney M (2004) Intranasal cocaine in humans: acute tolerance, cardiovascular and subjective effects. Pharmacol Biochem Behav 78:93–101

Article  CAS  PubMed  Google Scholar 

Gureckis TM, Love BC (2009) Learning in noise: dynamic decision-making in a variable environment. J Math Psychol 53:180–193

Article  PubMed  PubMed Central  Google Scholar 

Hay JL, White JM, Bochner F, Somogyi AA (2008) Antinociceptive effects of high dose remifentanil in male methadone-maintained patients. Eur J Pain 12:926–933

Article  CAS  PubMed  Google Scholar 

Huhn AS, Hobelmann JG, Oyler GA, Strain EC (2020) Protracted renal clearance of fentanyl in persons with opioid use disorder. Drug Alcohol Depend 214:108147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joint Economic Committee (2022) Accessed at https://www.jec.senate.gov/public/_cache/files/67bced7f-4232-40ea-9263-f033d280c567/jec-cost-of-opioids-issue-brief.pdf

Ko MC, Terner J, Hursh S, Woods JH, Winger G (2002) Relative reinforcing effects of three opioids with different durations of action. J Pharmacol Exp Ther 301:698–704

Article  CAS  PubMed  Google Scholar 

Lile JA, Stoops WW, Glaser PEA, Hays LR, Rush CR (2011) Physiological and subjective effects of acute intranasal methamphetamine during extended-release alprazolam maintenance. Drug Alcohol Depend 119:187–193

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lile JA, Stoops WW, Rush CR, Negus SS, Glaser PEA, Hatton KW, Hays LR (2016) Development of a translational model to screen medications for cocaine use disorder II: choice between cocaine and money in humans. Drug Alcohol Depend 165:111–119

Article  PubMed  PubMed Central  Google Scholar 

Lile JA, Johnson AR, Banks ML, Hatton KW, Hays LR, Nicholson KL, Poklis JL, Rayapati AO, Rush CR, Stoops WW, Negus SS (2020) Pharmacological validation of a translational model of cocaine use disorder: effects of d-amphetamine maintenance on choice between intravenous cocaine and a non-drug alternative in humans and rhesus monkeys. Exp Clin Psychopharmacol 28:169–180

Article  CAS  PubMed  Google Scholar 

Lofwall MR, Babalonis S, Nuzzo PA, Elayi SC, Walsh SL (2016) Opioid withdrawal suppression efficacy of oral dronabinol in opioid dependent humans. Drug Alcohol Depend 164:143–150

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin TJ, Walker LE, Sizemore GM, Smith JE, Dworkin SI (1996) Within-session determination of dose-response curves for heroin self-administration in rats: comparison with between-session determination and effects of naltrexone. Drug Alcohol Depend 41:93–100

Article  CAS  PubMed  Google Scholar 

Martinez S, Jones JD, Brandt L, Campbell ANC, Abbott RA, Comer SD (2021) The increasing prevalence of fentanyl: a urinalysis-based study among individuals with opioid use disorder in New York City. Am J Addict 30:65–71

Article  PubMed  Google Scholar 

Miezin FM, Maccotta L, Ollinger JM, Petersen SE, Buckner RL (2000) Characterizing the hemodynamic response: effects of presentation rate, sampling procedure, and the possibility of ordering brain activity based on relative timing. NeuroImage 11:735–759

Article  CAS  PubMed  Google Scholar 

Moss RB, Carlo DJ (2019) Higher doses of naloxone are needed in the synthetic opioid era. Subst Abuse Treat Prev Policy 14:6

Article  PubMed  PubMed Central  Google Scholar 

Niv Y, Daniel R, Geana A, Gershman SJ, Leong YC, Radulescu A, Wilson RC (2015) Reinforcement learning in multidimensional environments relies on attention mechanisms. J Neurosci 35:8145–8157

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oxecta® Product Information (2013) King Pharmaceuticals Inc., Bristol, Tennessee 37620, USA

Panlilio LV, Secci ME, Schindler CW, Bradberry CW (2017) Choice between delayed food and immediate opioids in rats: treatment effects and individual differences. Psychopharmacology 234:3361–3373

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poldrack R, Mumford J, Nichols T (2011) Statistical modeling: single subject analysis. Handbook of functional MRI Data Analysis. Cambridge University Press, Cambridge, pp 70–99. doi:https://doi.org/10.1017/CBO9780511895029.006.

Chapter  Google Scholar 

Smith AP, Beckmann JS (2021) Quantifying value-based determinants of drug and non-drug decision dynamics. Psychopharmacology 238:2037–2057

Article  Google Scholar 

Stoops WW, Pike E, Hays LR, Glaser PE, Rush CR (2015) Naltrexone and bupropion, alone or combined, do not alter the reinforcing effects of intranasal methamphetamine. Pharmacol Biochem Behav 129:45–50

Article  CAS  PubMed  Google Scholar 

Stoops WW, Strickland JC, Hatton KW, Hays LR, Rayapati AO, Lile JA, Rush CR (2022) Suvorexant maintenance enhances the reinforcing but not subjective and physiological effects of intravenous cocaine in humans. Pharmacol Biochem Behav 220:173466

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strang J, Volkow ND, Degenhardt L, Hickman M, Johnson K, Koob GF, Marshall BDL, Tyndall M, Walsh S (2020) Opioid use disorder. Nat Rev Dis Primers 6:3

Article  PubMed  Google Scholar 

Sutton RS, Barto AG (1998) Reinforcement learning: an introduction. MIT Press, Cambridge, MA

Google Scholar 

Torralva R, Janowsky A (2019) Noradrenergic mechanisms in fentanyl-mediated rapid death explain failure of naloxone in the opioid crisis. J Pharmacol Exp Ther 371:453–475

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ultiva® Product Information (2001) Abbot Laboratories, North Chicago. IL 60064, USA

Google Scholar 

Vearrier D, Grundmann O (2021) Clinical pharmacology, toxicity and abuse potential of opioids. J Clin Pharmacol 61(Suppl 2):S70–S88

CAS  PubMed  Google Scholar 

Volkow ND, Blanco C (2023) Fentanyl and other opioid use disorders: treatment and research needs. Am J Psychiatry 180:410–417

Article  PubMed  Google Scholar 

Wesson DR, Ling W (2003) The clinical opiate withdrawal scale. J Psychoact Drugs 35:253–259

Article  Google Scholar 

Zernig G, Giacomuzzi S, Riemer Y, Wakonigg G, Sturm K, Saria A (2003) Intravenous drug injection habits: drug users’ self-reports versus researchers’ perception. Pharmacology 68:49–56

Article  CAS  PubMed  Google Scholar 

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