Ahmed S, Riegsecker S, Beamer M, Rahman A, Bellini JV, Bhansali P, Tillekeratne LV (2013) Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts. Toxicol. https://doi.org/10.1016/j.taap.2013.04.014

Article  Google Scholar 

Angiolilli C, Grabiec AM, Ferguson BS, Ospelt C, Fernandez BM, van Es IE, Reedquist KA (2014) Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression. Ann Rheum Dis. https://doi.org/10.1136/annrheumdis-2014-205635

Article  PubMed  Google Scholar 

Angiolilli C, Kabala PA, Grabiec AM, Van Baarsen IM, Ferguson BS, García S, Reedquist KA (2017) Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes. Ann Rheum Dis. https://doi.org/10.1136/annrheumdis-2015-209064

Article  PubMed  Google Scholar 

Angiolilli C, Kabala PA, Grabiec AM, Rossato M, Lai WS, Fossati G, Radstake TR (2018) Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation. Arthritis Res Ther. https://doi.org/10.1186/s13075-018-1638-4

Article  PubMed  PubMed Central  Google Scholar 

Bae D, Choi Y, Lee J, Ha N, Suh D, Baek J, Son W (2021) M-134, a novel HDAC6-selective inhibitor, markedly improved arthritic severity in a rodent model of rheumatoid arthritis when combined with tofacitinib. Pharmacological Rep. https://doi.org/10.1007/s43440-020-00188-x

Article  Google Scholar 

Burrage PS, Mix KS, Brinckerhoff CE (2006) Matrix metalloproteinases: role i arthritis. Front Biosci. https://doi.org/10.2741/1817

Article  PubMed  Google Scholar 

Choi J, Gang S, Ramalingam M, Hwang J, Jeong H, Yoo J, Jang S (2023) BML-281 promotes neuronal differentiation by modulating Wnt/Ca2+ and Wnt/PCP signaling pathway. Mol Cell Biochem. https://doi.org/10.1007/s11010-023-04857-2

Article  PubMed  Google Scholar 

Choo QY, Ho PC, Tanaka Y, Lin HS (2010) Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF-κB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells. Rheumatology. https://doi.org/10.1093/rheumatology/keq108

Article  PubMed  Google Scholar 

Choo QY, Ho PC, Tanaka Y, Lin HS (2013) The histone deacetylase inhibitors MS-275 and SAHA suppress the p38 mitogen-activated protein kinase signaling pathway and chemotaxis in rheumatoid arthritic synovial fibroblastic E11 cells. Molecules 18:14085

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chung YL, Lee MY, Wang AJ, Yao LF (2003) A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. Mol Ther. https://doi.org/10.1016/s1525-0016(03)00235-1

Article  PubMed  Google Scholar 

Costenbader KH, Gay S, Alarcón-Riquelme ME, Iaccarino L, Doria A (2012) Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun Rev. https://doi.org/10.1016/j.autrev.2011.10.022

Article  PubMed  Google Scholar 

Cui SN, Chen ZY, Yang XB, Chen L, Yang YY, Pan SW, Shang Y (2019) Trichostatin A modulates the macrophage phenotype by enhancing autophagy to reduce inflammation during polymicrobial sepsis. Int Immunopharmcol. https://doi.org/10.1016/j.intimp.2019.105973

Article  Google Scholar 

Elshabrawy HA, Chen Z, Volin MV, Ravella S, Virupannavar S, Shahrara S (2015) The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis 18:433

Article  CAS  PubMed  PubMed Central  Google Scholar 

Furlan A, Monzani V, Reznikov LL, Leoni F, Fossati G, Modena D, Dinarello CA (2011) Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol Med. https://doi.org/10.2119/molmed.2011.00020

Article  PubMed  PubMed Central  Google Scholar 

Gerosa M, De Angelis V, Riboldi P, Meroni PL (2008) Rheumatoid arthritis: a female challenge. WHNP. https://doi.org/10.2217/17455057.4.2.195

Article  Google Scholar 

Gillespie J, Savic S, Wong C, Hempshall A, Inman M, Emery P, McDermott MF (2012) Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3–selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Rheum. https://doi.org/10.1002/art.33382

Article  PubMed  PubMed Central  Google Scholar 

Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Bonelli M (2020) Histone deacetylase 1 (HDAC1): a key player of T cell-mediated arthritis. J Autoimmun. https://doi.org/10.1016/j.jaut.2019.102379

Article  PubMed  Google Scholar 

Grabiec AM, Reedquist KA (2013) The ascent of acetylation in the epigenetics of rheumatoid arthritis. Nat Rev Rheumatol. https://doi.org/10.1038/nrrheum.2013.17

Article  PubMed  Google Scholar 

Grabiec AM, Krausz S, De Jager W, Burakowski T, Groot D, Sanders ME, Reedquist KA (2010) Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J Immunol. https://doi.org/10.4049/jimmunol.0901467

Article  PubMed  Google Scholar 

Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA (2011) Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. Ann Rheum Dis. https://doi.org/10.1136/ard.2011.154211

Article  PubMed  Google Scholar 

Ha MK, Song YH, Jeong SJ, Lee HJ, Jung JH, Kim B, Kim SH (2011) Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes. Biol Pharm Bull. https://doi.org/10.1248/bpb.34.1432

Article  PubMed  Google Scholar 

Hawtree S, Muthana M, Wilson AG (2013) The role of histone deacetylases in rheumatoid arthritis fibroblast-like synoviocytes. Biochem Soc Trans. https://doi.org/10.1042/BST20130053

Article  PubMed  Google Scholar 

Hawtree S, Muthana M, Wilkinson JM, Akil M, Wilson AG (2015) Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis. Hum Mol Genet. https://doi.org/10.1093/hmg/ddv258

Article  PubMed  Google Scholar 

Horiuchi M, Morinobu A, Chin T, Sakai Y, Kurosaka M, Kumagai S (2009) Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts. J Rheumatol. https://doi.org/10.3899/jrheum.081115

Article  PubMed  Google Scholar 

Hou J, Li Z, Fang Q, Feng C, Zhang H, Guo W, Wang PG (2012) Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead. J Med Chem. https://doi.org/10.1021/jm201496g

Article  PubMed  PubMed Central  Google Scholar 

Huber LC, Brock M, Hemmatazad H, Giger OT, Moritz F, Trenkmann M, Jüngel A (2007) Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients. Arthritis Rheum. https://doi.org/10.1002/art.22512

Article  PubMed  Google Scholar 

Ito T, Ouchida M, Morimoto Y, Yoshida A, Jitsumori Y, Ozaki T, Shimizu K (2005) Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo. Cancer Let. https://doi.org/10.1016/j.canlet.2004.10.030

Article  Google Scholar 

Kawabata T, Nishida K, Takasugi K, Ogawa H, Sada K, Kadota Y, Makino H (2010) Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis. Arthritis Res Ther 12:R133

Article  PubMed  PubMed Central  Google Scholar 

Kim DS, Kwon JE, Lee SH, Kim EK, Ryu JG, Jung KA, Kwok SK (2018) Attenuation of rheumatoid inflammation by sodium butyrate through reciprocal targeting of HDAC2 in osteoclasts and HDAC8 in T cells. Front Immunol. https://doi.org/10.3389/fimmu.2018.01525

Article  PubMed  PubMed Central  Google Scholar 

Klein K, Gay S (2013) Epigenetic modifications in rheumatoid arthritis, a review. Curr Opin Pharmacol. https://doi.org/10.1016/j.coph.2013.01.007

Article  PubMed  Google Scholar 

Kong S, Yeung P, Fang D (2013) The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis. J Genet Genomics. https://doi.org/10.1016/j.jgg.2013.04.001

Article  PubMed  PubMed Central  Google Scholar 

Konstantinopoulos PA, Vandoros GP, Papavassiliou AG (2006) FK228 (depsipeptide): a HDAC inhibitor with pleiotropic antitumor activities. Cancer Chemother Pharmacol. https://doi.org/10.1007/s00280-005-0182-5

Article  PubMed  Google Scholar 

Lee DM, Weinblatt ME (2001) Rheumatoid arthritis. Lancet. https://doi.org/10.1016/S0140-6736(01)06075-5

Article  PubMed  Google Scholar 

Lee EC, Kim YM, Lim HM, Ki GE, Seo YK (2020) The histone deacetylase inhibitor (MS-275) promotes differentiation of human dental pulp stem cells into odontoblast-like cells independent of the MAPK signaling system. Int J Mol Sci. https://doi.org/10.3390/ijms21165771

Article  PubMed  PubMed Central  Google Scholar 

Li M, Liu X, Sun X, Wang Z, Guo W, Hu F, Li Z (2013) Therapeutic effects of NK-HDAC-1, a novel histone deacetylase inhibitor, on collagen-induced arthritis through the induction of apoptosis of fibroblast-like synoviocytes. Inflammation. https://doi.org/10.1007/s10753-013-9616-0

Article  PubMed  Google Scholar 

Li Y, Zhou M, Lv X, Song L, Zhang D, He Y, Wang D (2018) Reduced activity of HDAC3 and increased acetylation of histones H3 in peripheral blood mononuclear cells of patients with rheumatoid arthritis. J Immunol Res 2018:1

Google Scholar 

Lin HS, Hu CY, Chan HY, Liew YY, Huang HP, Lepescheux L, Clément-Lacroix P (2007) Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br J Pharmacol. https://doi.org/10.1038/sj.bjp.0707165