Adamcakova J, Balentova S, Barosova R, Hanusrichterova J, Mikolka P, Prso K, Mokry J, Tatarkova Z, Kalenska D, Mokra D (2023) Effects of green tea polyphenol epigallocatechin-3-gallate on markers of inflammation and fibrosis in a rat model of pulmonary silicosis. Int J Mol Sci 24:1857

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agackiran Y, Gul H, Gunay E, Akyurek N, Memis L, Gunay S, Sirin YS, Ide T (2012) The efficiency of proanthocyanidin in an experimental pulmonary fibrosis model: comparison with taurine. Inflammation 35:1402–1410

Article  CAS  PubMed  Google Scholar 

Alharbi KS, Fuloria NK, Fuloria S, Rahman SB, Al-Malki WH, Javed S, Thangavelu L, Singh SK, Rama RA, Jha NK, Chellappan DK, Dua K, Gupta G (2021) Nuclear factor-kappa B and its role in inflammatory lung disease. Chem Biol Interact 345:109568

Article  CAS  PubMed  Google Scholar 

Ameeramja J, Perumal E (2018) Possible modulatory effect of tamarind seed coat extract on fluoride-induced pulmonary inflammation and fibrosis in rats. Inflammation 41:886–895

Article  CAS  PubMed  Google Scholar 

An L, Peng LY, Sun NY, Yang YL, Zhang XW, Li B, Liu BL, Li P, Chen J (2019) Tanshinone IIA activates nuclear factor-erythroid 2-related factor 2 to restrain pulmonary fibrosis via regulation of redox homeostasis and glutaminolysis. Antioxid Redox Signal 30:1831–1848

Article  CAS  PubMed  Google Scholar 

Avila-Carrasco L, Majano P, Sanchez-Tomero JA, Selgas R, Lopez-Cabrera M, Aguilera A, Gonzalez MG (2019) Natural plants compounds as modulators of epithelial-to-mesenchymal transition. Front Pharmacol 10:715

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bacchetti T, Morresi C, Bellachioma L, Ferretti G (2020) Antioxidant and pro-oxidant properties of carthamus tinctorius, hydroxy safflor yellow A, and safflor yellow A. Antioxidants 9:119

Article  PubMed  PubMed Central  Google Scholar 

Behr J (2013) Evidence-based treatment strategies in idiopathic pulmonary fibrosis. Eur Respir Rev 22:163–168

Article  PubMed  PubMed Central  Google Scholar 

Behr J, Prasse A, Kreuter M, Johow J, Rabe KF, Bonella F, Bonnet R, Grohe C, Held M, Wilkens H, Hammerl P, Koschel D, Blaas S, Wirtz H, Ficker JH, Neumeister W, Schonfeld N, Claussen M, Kneidinger N, Frankenberger M, Hummler S, Kahn N, Tello S, Freise J, Welte T, Neuser P, Gunther A, Investigators R (2021) Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial. Lancet Respir Med 9:476–486

Article  CAS  PubMed  Google Scholar 

Bergman ME, Davis B, Phillips MA (2019) Medically useful plant terpenoids: biosynthesis, occurrence, and mechanism of action. Molecules 24:3961

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bi Z, Wang Y, Zhang W (2021) A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment. Biomed Pharmacother 137:111404

Article  CAS  PubMed  Google Scholar 

Burman A, Tanjore H, Blackwell TS (2018) Endoplasmic reticulum stress in pulmonary fibrosis. Matrix Biol 68–69:355–365

Article  PubMed  PubMed Central  Google Scholar 

Chauhan PS, Dash D, Singh R (2017) Intranasal curcumin inhibits pulmonary fibrosis by modulating matrix metalloproteinase-9 (MMP-9) in ovalbumin-induced chronic asthma. Inflammation 40:248–258

Article  CAS  PubMed  Google Scholar 

Chen H, Chen Q, Jiang CM, Shi GY, Sui BW, Zhang W, Yang LZ, Li ZY, Liu L, Su YM, Zhao WC, Sun HQ, Li ZZ, Fu Z (2018) Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition. Toxicol Lett 284:1–9

Article  CAS  PubMed  Google Scholar 

Chitra P, Saiprasad G, Manikandan R, Sudhandiran G (2013) Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-kappaB dependant TGF-beta activation: a biphasic experimental study. Toxicol Lett 219:178–193

Article  CAS  PubMed  Google Scholar 

Chitra P, Saiprasad G, Manikandan R, Sudhandiran G (2015) Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis. J Mol Med (berl) 93:1015–1031

Article  CAS  PubMed  Google Scholar 

Cho IH, Choi YJ, Gong JH, Shin D, Kang MK, Kang YH (2015) Astragalin inhibits autophagy-associated airway epithelial fibrosis. Respir Res 16:51

Article  PubMed  PubMed Central  Google Scholar 

Cui X, Sun X, Lu F, Jiang X (2018) Baicalein represses TGF-beta1-induced fibroblast differentiation through the inhibition of miR-21. Toxicol Appl Pharmacol 358:35–42

Article  CAS  PubMed  Google Scholar 

Divya T, Velavan B, Sudhandiran G (2018) Regulation of transforming growth factor-β/smad-mediated epithelial-mesenchymal transition by celastrol provides protection against bleomycin-induced pulmonary fibrosis. Basic Clin Pharmacol Toxicol 123:122–129

Article  CAS  PubMed  Google Scholar 

El-Baba C, Baassiri A, Kiriako G, Dia B, Fadlallah S, Moodad S, Darwiche N (2021) Terpenoids’ anti-cancer effects: focus on autophagy. Apoptosis 26:491–511

Article  CAS  PubMed  Google Scholar 

Feng F, Cheng P, Xu S, Li N, Wang H, Zhang Y, Wang W (2020) Tanshinone IIA attenuates silica-induced pulmonary fibrosis via Nrf2-mediated inhibition of EMT and TGF-beta1/Smad signaling. Chem Biol Interact 319:109024

Article  CAS  PubMed  Google Scholar 

Gao Y, Lu J, Zhang Y, Chen Y, Gu Z, Jiang X (2013) Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21. Pulm Pharmacol Ther 26:649–654

Article  CAS  PubMed  Google Scholar 

Guan R, Wang X, Zhao X, Song N, Zhu J, Wang J, Wang J, Xia C, Chen Y, Zhu D, Shen L (2016) Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation. Sci Rep 6:35696

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guan S, Liu Q, Han F, Gu W, Song L, Zhang Y, Guo X, Xu W (2017) Ginsenoside Rg1 ameliorates cigarette smoke-induced airway fibrosis by suppressing the TGF-β1/smad pathway in vivo and in vitro. Biomed Res Int 2017:1–12

Google Scholar 

Guo K, Chen J, Chen Z, Luo G, Yang S, Zhang M, Hong J, Zhang L, Chen C (2020) Triptolide alleviates radiation-induced pulmonary fibrosis via inhibiting IKKbeta stimulated LOX production. Biochem Biophys Res Commun 527:283–288

Article  CAS  PubMed  Google Scholar 

Haak AJ, Tan Q, Tschumperlin DJ (2018) Matrix biomechanics and dynamics in pulmonary fibrosis. Matrix Biol 73:64–76

Article  CAS  PubMed  Google Scholar 

Hasan M, Paul NC, Paul SK, Saikat ASM, Akter H, Mandal M, Lee S-S (2022) Natural product-based potential therapeutic interventions of pulmonary fibrosis. Molecules 27:1481

Article  CAS  PubMed  PubMed Central  Google Scholar 

He H, Tang H, Gao L, Wu Y, Feng Z, Lin H, Wu T (2015) Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats. Mol Med Rep 11:4190–4196

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hewlett JC, Kropski JA, Blackwell TS (2018) Idiopathic pulmonary fibrosis: epithelial-mesenchymal interactions and emerging therapeutic targets. Matrix Biol 71–72:112–127

Article  PubMed  PubMed Central  Google Scholar 

Hosseini S, Imenshahidi M, Hosseinzadeh H, Karimi G (2018) Effects of plant extracts and bioactive compounds on attenuation of bleomycin-induced pulmonary fibrosis. Biomed Pharmacother 107:1454–1465

Article  CAS  PubMed  Google Scholar 

Huang X, He Y, Chen Y, Wu P, Gui D, Cai H, Chen A, Chen M, Dai C, Yao D, Wang L (2016) Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF-beta1-induced ERK1/2 signaling pathway. BMC Pulm Med 16:132

Article  PubMed  PubMed Central  Google Scholar 

Huang XT, Liu W, Zhou Y, Hao CX, Zhou Y, Zhang CY, Sun CC, Luo ZQ, Tang SY (2019) Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-κB signaling in an Nrf2-dependent manner. Int J Mol Med 44:2213–2222

CAS  PubMed  PubMed Central  Google Scholar 

Impellizzeri D, Talero E, Siracusa R, Alcaide A, Cordaro M, Maria ZJ, Bruschetta G, Crupi R, Esposito E, Cuzzocrea S, Motilva V (2015) Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice. Br J Nutr 114:853–865

Article  CAS  PubMed  Google Scholar 

Javad-Mousavi SA, Hemmati AA, Mehrzadi S, Hosseinzadeh A, Houshmand G, Rashidi NMR, Mehrabani M, Goudarzi M (2016) Protective effect of Berberis vulgaris fruit extract against Paraquat-induced pulmonary fibrosis in rats. Biomed Pharmacother 81:329–336

Article  CAS  PubMed  Google Scholar 

Ji Y, Dou Y-N, Zhao Q-W, Zhang J-Z, Yang Y, Wang T, Xia Y-F, Dai Y, Wei Z-F (2016) Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway. Acta Pharmacol Sin 37:794–804