Al-Yafeai Z, Yurdagul A Jr, Peretik JM, Alfaidi M, Murphy PA, Orr AW (2018) Endothelial FN (fibronectin) deposition by alpha5beta1 integrins drives atherogenic inflammation. Arterioscler Thromb Vasc Biol 38:2601–2614. https://doi.org/10.1161/ATVBAHA.118.311705

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alestrom P, D’Angelo L, Midtlyng PJ, Schorderet DF, Schulte-Merker S, Sohm F et al (2019) Zebrafish: housing and husbandry recommendations. Lab Anim. https://doi.org/10.1177/0023677219869037

Article  PubMed  PubMed Central  Google Scholar 

Arora K, Shah M, Johnson M, Sanghvi R, Shelton J, Nagulapalli K et al (2019) Deep whole-genome sequencing of 3 cancer cell lines on 2 sequencing platforms. Sci Rep 9:19123. https://doi.org/10.1038/s41598-019-55636-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bell CC (1994) DSM-IV: diagnostic and statistical manual of mental disorders. JAMA 272:828–829. https://doi.org/10.1001/jama.1994.03520100096046

Article  Google Scholar 

Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R et al (2010) Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68:409–427. https://doi.org/10.1016/j.neuron.2010.09.043

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellaver B, Povala G, Ferreira PCL, Ferrari-Souza JP, Leffa DT, Lussier FZ et al (2023) Astrocyte reactivity influences amyloid-beta effects on tau pathology in preclinical Alzheimer’s disease. Nat Med 29:1775–1781. https://doi.org/10.1038/s41591-023-02380-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellenguez C, Kucukali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N et al (2022) New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet. https://doi.org/10.1038/s41588-022-01024-z

Article  PubMed  PubMed Central  Google Scholar 

Belloy ME, Eger SJ, Le Guen Y, Damotte V, Ahmad S, Ikram MA et al (2022) Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping. Alzheimers Res Ther 14:22. https://doi.org/10.1186/s13195-022-00962-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belloy ME, Andrews SJ, Le Guen Y, Cuccaro M, Farrer LA, Napolioni V et al (2023) APOE genotype and Alzheimer disease risk across age, sex, and population ancestry. JAMA Neurol 80:1284–1294. https://doi.org/10.1001/jamaneurol.2023.3599

Article  PubMed  PubMed Central  Google Scholar 

Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF et al (2006) Decision rules guiding the clinical diagnosis of Alzheimer’s disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology 27:169–176. https://doi.org/10.1159/000096129

Article  PubMed  Google Scholar 

Bhattarai P, Cosacak MI, Mashkaryan V, Demir S, Popova S, Govindarajan N et al (2020) Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain. PLoS Biol 18:e3000585. https://doi.org/10.1371/journal.pbio.3000585

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhattarai P, Thomas AK, Cosacak MI, Papadimitriou C, Mashkaryan V, Zhang Y et al (2017) Modeling amyloid-β42 toxicity and neurodegeneration in adult zebrafish brain. J Vis Exp. https://doi.org/10.3791/56014

Article  PubMed  PubMed Central  Google Scholar 

Bhattarai P, Thomas AK, Papadimitriou C, Cosacak MI, Mashkaryan V, Froc C et al (2016) IL4/STAT6 signaling activates neural stem cell proliferation and neurogenesis upon Amyloid-β42 aggregation in adult zebrafish brain. Cell Rep 17:941–948. https://doi.org/10.1016/j.celrep.2016.09.075

Article  CAS  PubMed  Google Scholar 

Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM et al (2022) APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature 611:769–779. https://doi.org/10.1038/s41586-022-05439-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogdan S, Puscion-Jakubik A, Klimiuk K, Socha K, Kochanowicz J, Gorodkiewicz E (2022) The concentration of fibronectin and MMP-1 in patients with Alzheimer's disease in relation to the selected antioxidant elements and eating habits. J Clin Med. https://doi.org/10.3390/jcm11216360

Burda JE, Sofroniew MV (2014) Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 81:229–248. https://doi.org/10.1016/j.neuron.2013.12.034. (S0896-6273(14)00011-7 [pii])

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K et al (2018) The UK Biobank resource with deep phenotyping and genomic data. Nature 562:203–209. https://doi.org/10.1038/s41586-018-0579-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao L, Nicosia J, Larouche J, Zhang Y, Bachman H, Brown AC et al (2017) Detection of an integrin-binding mechanoswitch within fibronectin during tissue formation and fibrosis. ACS Nano 11:7110–7117. https://doi.org/10.1021/acsnano.7b02755

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen CY, Pollack S, Hunter DJ, Hirschhorn JN, Kraft P, Price AL (2013) Improved ancestry inference using weights from external reference panels. Bioinformatics 29(11):1399–1406. https://doi.org/10.1093/bioinformatics/btt144

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chhum P, Yu H, An B, Doyon BR, Lin YS, Brodsky B (2016) Consequences of glycine mutations in the fibronectin-binding sequence of collagen. J Biol Chem 291:27073–27086. https://doi.org/10.1074/jbc.M116.753566

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261:921–923

Article  CAS  PubMed  Google Scholar 

Cosacak MI, Bhattarai P, De Jager PL, Menon V, Tosto G, Kizil C (2022) Single cell/nucleus transcriptomics comparison in zebrafish and humans reveals common and distinct molecular responses to Alzheimer’s disease. Cells 11:1807. https://doi.org/10.3390/cells11111807

Cosacak MI, Bhattarai P, Kizil C (2020) Protocol for dissection and dissociation of zebrafish telencephalon for single-cell sequencing. STAR Protoc 1:100042. https://doi.org/10.1016/j.xpro.2020.100042

Article  PubMed  PubMed Central  Google Scholar 

Cosacak MI, Bhattarai P, Reinhardt S, Petzold A, Dahl A, Zhang Y et al (2019) Single-cell transcriptomics analyses of neural stem cell heterogeneity and contextual plasticity in a zebrafish brain model of amyloid toxicity. Cell Rep 27(1307–1318):e1303. https://doi.org/10.1016/j.celrep.2019.03.090

Article  CAS  Google Scholar 

Daneman R, Zhou L, Kebede AA, Barres BA (2010) Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468:562–566. https://doi.org/10.1038/nature09513

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A et al (2016) Next-generation genotype imputation service and methods. Nat Genet 48(10):1284–1287. https://doi.org/10.1038/ng.3656

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T et al (2022) Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature 611:585–593. https://doi.org/10.1038/s41586-022-05397-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R et al (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278:1349–1356

Article  CAS  PubMed  Google Scholar 

Fitch MT, Silver J (2008) CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp Neurol 209:294–301. https://doi.org/10.1016/j.expneurol.2007.05.014. (S0014-4886(07)00213-0 [pii])

Article  CAS  PubMed  Google Scholar 

Geisler R, Borel N, Ferg M, Maier JV, Strahle U (2016) Maintenance of zebrafish lines at the European Zebrafish Resource Center. Zebrafish 13(Suppl 1):S19-23. https://doi.org/10.1089/zeb.2015.1205

Article  PubMed  Google Scholar 

Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O et al (2011) APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry 16:903–907. https://doi.org/10.1038/mp.2011.52

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu Y, Beato JM, Amarante E, Chesebro AG, Manly JJ, Schupf N et al (2020) Assessment of leisure time physical activity and brain health in a multiethnic cohort of older adults. JAMA Netw Open 3:e2026506. https://doi.org/10.1001/jamanetworkopen.2020.26506

Article  PubMed  PubMed Central  Google Scholar 

Guillon E, Das D, Julich D, Hassan AR, Geller H, Holley S (2020) Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development. Elife. https://doi.org/10.7554/eLife.48964