JNK inhibition enhances cell–cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes

Amagai M, Stanley JR (2012) Desmoglein as a target in skin disease and beyond. J Invest Dermatol 132(3 Pt. 2):776–784. https://doi.org/10.1038/jid.2011.390

Article  CAS  PubMed  Google Scholar 

Amagai M, Fujimori T, Masunaga T, Shimizu H, Nishikawa T, Shimizu N, Takeichi M, Hashimoto T (1995) Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant. J Invest Dermatol 104(1):27–32. https://doi.org/10.1111/1523-1747.ep12613462

Article  CAS  PubMed  Google Scholar 

Aono S, Hirai Y (2008) Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp Cell Res 314(18):3326–3339. https://doi.org/10.1016/j.yexcr.2008.08.012

Article  CAS  PubMed  Google Scholar 

Baron S, Hoang A, Vogel H, Attardi LD (2012) Unimpaired skin carcinogenesis in desmoglein 3 knockout mice. PLoS ONE 7(11):e50024. https://doi.org/10.1371/journal.pone.0050024

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS (2005) Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem 280(25):23778–23784. https://doi.org/10.1074/jbc.M501365200

Article  CAS  PubMed  Google Scholar 

Berkowitz P, Hu P, Warren S, Liu Z, Diaz LA, Rubenstein DS (2006) P38MAPK inhibition prevents disease in pemphigus vulgaris mice. Proc Natl Acad Sci USA 103(34):12855–12860. https://doi.org/10.1073/pnas.0602973103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogoyevitch MA, Court NW (2004) Counting on mitogen-activated protein kinases–ERKs 3, 4, 5, 6, 7 and 8. Cell Signal 16(12):1345–1354. https://doi.org/10.1016/j.cellsig.2004.05.004

Article  CAS  PubMed  Google Scholar 

Chernyavsky AI, Arredondo J, Kitajima Y, Sato-Nagai M, Grando SA (2007) Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens. J Biol Chem 282(18):13804–13812. https://doi.org/10.1074/jbc.M611365200

Article  CAS  PubMed  Google Scholar 

Delva E, Tucker DK, Kowalczyk AP (2009) The desmosome. Cold Spring Harb Perspect Biol 1(2):a002543. https://doi.org/10.1101/cshperspect.a002543

Article  PubMed  PubMed Central  Google Scholar 

Garcia MA, Nelson WJ, Chavez N (2018) Cell-cell junctions organize structural and signaling networks. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a029181

Article  PubMed  PubMed Central  Google Scholar 

Garrod D, Chidgey M (2008) Desmosome structure, composition and function. Biochim Biophys Acta 1778(3):572–587. https://doi.org/10.1016/j.bbamem.2007.07.014

Article  CAS  PubMed  Google Scholar 

Hagemann C, Blank JL (2001) The ups and downs of MEK kinase interactions. Cell Signal 13(12):863–875. https://doi.org/10.1016/s0898-6568(01)00220-0

Article  CAS  PubMed  Google Scholar 

Hanakawa Y, Amagai M, Shirakata Y, Sayama K, Hashimoto K (2000) Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes. J Cell Sci 113(10):1803–1811. https://doi.org/10.1242/jcs.113.10.1803

Article  CAS  PubMed  Google Scholar 

Hanakawa Y, Matsuyoshi N, Stanley JR (2002) Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion. J Invest Dermatol 119(1):27–31. https://doi.org/10.1046/j.1523-1747.2002.01780.x

Article  CAS  PubMed  Google Scholar 

Hartlieb E, Kempf B, Partilla M, Vigh B, Spindler V, Waschke J (2013) Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. PLoS ONE 8(1):e53739. https://doi.org/10.1371/journal.pone.0053739

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hartlieb E, Rötzer V, Radeva M, Spindler V, Waschke J (2014) Desmoglein 2 compensates for desmoglein 3 but does not control cell adhesion via regulation of p38 mitogen-activated protein kinase in keratinocytes. J Biol Chem 289(24):17043–17053. https://doi.org/10.1074/jbc.M113.489336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishii T, Hayakawa H, Igawa T, Sekiguchi T, Sekiguchi M (2018) Specific binding of PCBP1 to heavily oxidized RNA to induce cell death. Proc Natl Acad Sci USA 115(26):6715–6720. https://doi.org/10.1073/pnas.1806912115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishikawa S, Nikaido M, Otani T, Ogata K, Iida H, Inai Y, Tamaoki S, Inai T (2022) Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes. Microscopy 71(3):152–160. https://doi.org/10.1093/jmicro/dfac007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH, Kim SE, Park HS, Lee SH, Lee SE, Kim SC (2019) A homozygous nonsense mutation in the DSG3 gene causes acantholytic blisters in the oral and laryngeal mucosa. J Invest Dermatol 139(5):1187–1190. https://doi.org/10.1016/j.jid.2018.09.038

Article  CAS  PubMed  Google Scholar 

Kitagawa N, Inai Y, Higuchi Y, Iida H, Inai T (2014) Inhibition of JNK in HaCaT cells induced tight junction formation with decreased expression of cytokeratin 5, cytokeratin 17 and desmoglein 3. Histochem Cell Biol 142(4):389–399. https://doi.org/10.1007/s00418-014-1219-9

Article  CAS  PubMed  Google Scholar 

Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR (1997) Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 137(5):1091–1102. https://doi.org/10.1083/jcb.137.5.1091

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, Kikuchi S, Ogasawara N, Ohkuni T, Masaki T, Hirata K, Himi T, Sawada N (2010) C-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J Cell Physiol 225(3):720–733. https://doi.org/10.1002/jcp.22273

Article  CAS  PubMed  Google Scholar 

Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81(2):807–869. https://doi.org/10.1152/physrev.2001.81.2.807

Article  CAS  PubMed  Google Scholar 

Lewis JE, Jensen PJ, Wheelock MJ (1994) Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium. J Invest Dermatol 102(6):870–877. https://doi.org/10.1111/1523-1747.ep12382690

Article  CAS  PubMed  Google Scholar 

Lichti U, Anders J, Yuspa SH (2008) Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc 3(5):799–810. https://doi.org/10.1038/nprot.2008.50

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR (1999) Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 103(4):461–468. https://doi.org/10.1172/JCI5252

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minakami M, Kitagawa N, Iida H, Anan H, Inai T (2015) p38 mitogen-activated protein kinase and c-Jun NH2-terminal protein kinase regulate the accumulation of a tight junction protein, ZO-1, in cell-cell contacts in HaCaT cells. Tissue Cell 47(1):1–9. https://doi.org/10.1016/j.tice.2014.10.001

Article  CAS  PubMed  Google Scholar 

Naydenov NG, Hopkins AM, Ivanov AI (2009) C-Jun N-terminal kinase mediates disassembly of apical junctions in model intestinal epithelia. Cell Cycle 8(13):2110–2121. https://doi.org/10.4161/cc.8.13.8928

Article  CAS  PubMed  Google Scholar 

Nikaido M, Otani T, Kitagawa N, Ogata K, Iida H, Anan H, Inai T (2019) Anisomycin, a JNK and p38 activator, suppresses cell-cell junction formation in 2D cultures of K38 mouse keratinocyte cells and reduces claudin-7 expression, with an increase of paracellular permeability in 3D cultures. Histochem Cell Biol 151(5):369–384. https://doi.org/10.1007/s00418-018-1736-z

Article  CAS  PubMed  Google Scholar 

Pearson LL, Castle BE, Kehry MR (2001) CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways. Int Immunol 13(3):273–283. https://doi.org/10.1093/intimm/13.3.273

Article  CAS  PubMed  Google Scholar 

Reichelt J, Haase I (2010) Establishment of spontaneously immortalized keratinocyte lines from wild-type and mutant mice. Methods Mol Biol 585:59–69. https://doi.org/10.1007/978-1-60761-380-0_5

Article  CAS 

留言 (0)

沒有登入
gif