DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy

Abraham MC, Shaham S (2014) Death without caspases, caspases without death. Trends Cell Biol 14(4):184–193

Article  Google Scholar 

Balko JM, Schwarz LJ, Bhola NE, Kurupi R, Owens P, Miller TW, Gómez H, Cook RS, Arteaga CL (2013) Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer. Cancer Res 73(20):6346–6358

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T, Ghadimi BM (2010) Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. Genes Chromosomes Cancer 49(11):1024–1034

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gröschl B, Bettstetter M, Giedl C, Woenckhaus M, Edmonston T, Hofstädter F, Dietmaier W (2013) Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. Int J Cancer 132(7):1537–1546

Article  PubMed  Google Scholar 

Han J, Ye S, Chen J, Wang K, Jin J, Zeng Z, Xue S (2021) Lysine-specific histone demethylase 1 promotes oncogenesis of the esophageal squamous cell carcinoma by upregulating DUSP4. Biochemistry (mosc) 86(12):1624–1634

Article  CAS  PubMed  Google Scholar 

He H, Du Z, Lin J, Wu W, Yu Y (2021) DUSP4 inhibits autophagic cell death in PTC by inhibiting JNK-BCL2-Beclin1 signaling. Biochem Cell Biol 99(5):554–561

Article  CAS  PubMed  Google Scholar 

Hou G, Zhao Q, Zhang M, Wang P, Ye H, Wang Y, Ren Y, Zhang J, Lu Z (2019) LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma. Onco Targets Ther 12:5215–5225

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ke D, Ji L, Wang Y, Fu X, Chen J, Wang F, Zhao D, Xue Y, Lan X, Hou J (2019) JNK1 regulates RANKL-induced osteoclastogenesis via activation of a novel Bcl-2-Beclin1-autophagy pathway. FASEB J 33(10):11082–11095

Article  CAS  PubMed  Google Scholar 

Kelkel M, Cerella C, Mack F, Schneider T, Jacob C, Schumacher M, Dicato M, Diederich M (2012) ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis 33(11):2162–2171

Article  CAS  PubMed  Google Scholar 

Keyse SM (2008) Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev 27(2):253–261

Article  CAS  PubMed  Google Scholar 

Kutty RG, Talipov MR, Bongard RD, Lipinski RAJ, Sweeney NL, Sem DS, Rathore R, Ramchandran R (2017) Dual specificity phosphatase 5-substrate interaction: a mechanistic perspective. Compr Physiol 7(4):1449–1461

Article  PubMed  Google Scholar 

Liu J, Lin A (2005) Role of JNK activation in apoptosis: a double-edged sword. Cell Res 15(1):36–42

Article  PubMed  ADS  Google Scholar 

Liu S, Lin H, Wang D, Li Q, Luo H, Li G, Chen X, Li Y, Chen P, Zhai B, Wang W, Zhang R, Chen B, Zhang M, Han X, Li Q, Chen L, Liu Y, Chen X, Li G, Xiang Y, Duan T, Feng J, Lou J, Huang X, Zhang Q, Pan T, Yan L, Jin T, Zhang W, Zhuo L, Sun Y, Xie T, Sui X (2019) PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death. Signal Transduct Target Ther 4:53

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu YW, Yang T, Zhao L, Ni Z, Yang N, He F, Dai SS (2016) Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Sci Rep 6:33614

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Low HB, Zhang Y (2016) Regulatory roles of MAPK phosphatases in cancer. Immune Netw 16(2):85–98

Article  PubMed  PubMed Central  Google Scholar 

Lu Z, Ren Y, Zhang M, Fan T, Wang Y, Zhao Q, Liu HM, Zhao W, Hou G (2018) FLI-06 suppresses proliferation, induces apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells. Biomed Pharmacother 107:1370–1376

Article  CAS  PubMed  Google Scholar 

Ma B, Shi R, Yang S, Zhou L, Qu N, Liao T, Wang Y, Wang Y, Ji Q (2016) DUSP4/MKP2 overexpression is associated with BRAF(V600E) mutation and aggressive behavior of papillary thyroid cancer. Onco Targets Ther 9:2255–2263

CAS  PubMed  PubMed Central  Google Scholar 

Matsuda T, Ajiki W, Marugame T, Ioka A, Tsukuma H, Sobue T, Research Group of Population-Based Cancer Registries of Japan (2011) Population-based survival of cancer patients diagnosed between 1993 and 1999 in Japan: a chronological and international comparative study. Jpn J Clin Oncol. 41(1):40–51

Article  PubMed  Google Scholar 

Nazim UM, Yin H, Park SY (2020) Neferine treatment enhances the TRAIL-induced apoptosis of human prostate cancer cells via autophagic flux and the JNK pathway. Int J Oncol 56(5):1152–1161

CAS  PubMed  PubMed Central  Google Scholar 

Ni Z, Wang B, Dai X, Ding W, Yang T, Li X, Lewin S, Xu L, Lian J, He F (2014) HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS-JNK-autophagy pathway. Free Radic Biol Med 70:194–203

Article  CAS  PubMed  Google Scholar 

Park KJ, Lee SH, Lee CH, Jang JY, Chung J, Kwon MH, Kim YS (2009) Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death. Biochem Biophys Res Commun 382(4):726–729

Article  CAS  PubMed  Google Scholar 

Pattingre S, Bauvy C, Levade T, Levine B, Codogno P (2009) Ceramide-induced autophagy: to junk or to protect cells? Autophagy 5(4):558–560

Article  CAS  PubMed  Google Scholar 

Pennathur A, Gibson MK, Jobe BA, Luketich JD (2013) Oesophageal carcinoma. Lancet 381(9864):400–412

Article  PubMed  Google Scholar 

Prabhakar S, Asuthkar S, Lee W, Chigurupati S, Zakharian E, Tsung AJ, Velpula KK (2014) Targeting DUSPs in glioblastomas-wielding a double-edged sword? Cell Biol Int 38(2):145–153

Article  CAS  PubMed  Google Scholar 

Qin X, Lu A, Ke M, Zhu W, Ye X, Wang G, Weng G (2020) DJ-1 inhibits autophagy activity of prostate cancer cells by repressing JNK-Bcl2-Beclin1 signaling. Cell Biol Int 44(4):937–946

Article  CAS  PubMed  Google Scholar 

Siegel R, Naishadham D, Jemal A (2012) Cancer statistic. CA Cancer J Clin 62(1):10–29

Article  PubMed  Google Scholar 

Umar SB, Fleischer DE (2018) Esophageal cancer: epidemiology, pathogenesis and prevention. Nat Clin Pract Gastroenterol Hepatol 5(9):517–526

Article  Google Scholar 

Wang B, Zhao B, Pang LP, Zhao YD, Guo Q, Wang JW, Zheng YC, Zhang XH, Liu Y, Liu GY, Guo WG, Wang C, Li ZH, Mao XJ, Yu B, Ma LY, Liu HM (2017) LPE-1, an orally active pyrimidine derivative, inhibits growth and mobility of human esophageal cancers by targeting LSD1. Pharmacol Res 122:66–77

Article  CAS  PubMed  Google Scholar 

Wang HY, Cheng Z, Malbon CC (2003) Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Cancer Lett 191(2):229–237

Article  CAS  PubMed  Google Scholar 

Wei Y, Pattingre S, Sinha S, Bassik M, Levine B (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 30(6):678–688

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu X, Gao F, Wang J, Tao L, Ye J, Ding L, Ji W, Chen X (2018) MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4. Cancer Biol Ther 19(5):427–435

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yip-Schneider MT, Lin A, Marshall MS (2001) Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2. Biochem Biophys Res Commun 280(4):992–997

Article  CAS  PubMed  Google Scholar 

Zeng X, Zhu C, Zhu X (2021) DUSP4 promotes the carcinogenesis of CCRCC via negative regulation of autophagic death. Biosci Biotechnol Biochem 85(8):1839–1845

Article  PubMed  Google Scholar 

Zhou N, Wei Z, Qi Z, Chen L (2021) Abscisic acid-induced autophagy selectively via MAPK/JNK signalling pathway in glioblastoma. Cell Mol Neurobiol 41(4):813–826

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif