What Do We Know So Far About Ventricular Arrhythmias and Sudden Cardiac Death Prediction in the Mitral Valve Prolapse Population? Could Biomarkers Help Us Predict Their Occurrence?

Shah SN, Gangwani MK, Oliver TI. Mitral Valve Prolapse. [Updated 2023 Jan 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470288/ 

Nalliah CJ, Mahajan R, Elliott AD, et al. Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis. Heart. 2019;105(2):144–51. https://doi.org/10.1136/heartjnl-2017-312932. Epub 2018 Sep 21 PMID: 30242141.

Article  PubMed  Google Scholar 

Theal M, Sleik K, Anand S, et al. Prevalence of mitral valve prolapse in ethnic groups. Can J Cardiol. 2004;20(5):511–5 PMID: 15100753.

PubMed  Google Scholar 

Hjortnaes J, Keegan J, Bruneval P, et al. Comparative histopathological analysis of mitral valves in Barlow disease and fibroelastic deficiency. Semin Thorac Cardiovasc Surg. 2016;28(4):757–67. https://doi.org/10.1053/j.semtcvs.2016.08.015. Epub 2016 Sep 5. PMID: 28417861.

Article  PubMed  Google Scholar 

Levine RA, Hagége AA, Judge DP, et al. Leducq Mitral Transatlantic Network. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015;12(12):689–710. https://doi.org/10.1038/nrcardio.2015.161. Epub 2015 Oct 20. PMID: 26483167; PMCID: PMC4804623.

Article  CAS  PubMed  PubMed Central  Google Scholar 

•• Raina A, Gersh BJ, Asirvatham SJ, et al. Characterization of ventricular arrhythmias and sudden cardiac death in subjects with mitral valve prolapse and mitral annular disjunction. Heart Rhythm. 2023;20(1):112–21. https://doi.org/10.1016/j.hrthm.2022.09.008. Conclusions of this meta-analysis define female gender, bi-leaflet prolapse, thickening of mitral valve leaflets, Pickelhaube sign, mitral annulus disjunction, and late gadolinium enhancement on CMR as predictors of ventricular arrhythmia in the MVP population. Moreover, several ECG findings like T wave inversion and QT dispersion, high PVC burden, and fast or inducible VT were determined as arrhythmic episode predictors.

Article  PubMed  Google Scholar 

Delling FN, Vasan RS. Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation. 2014;129(21):2158–70. https://doi.org/10.1161/CIRCULATIONAHA.113.006702. PMID: 24867995; PMCID: PMC4052751.

Article  PubMed  PubMed Central  Google Scholar 

Hayek E, Gring CN, Griffin BP. Mitral valve prolapse. Lancet. 2005;365(9458):507–18. https://doi.org/10.1016/S0140-6736(05)17869-6. PMID: 15705461.

Article  PubMed  Google Scholar 

Yoon SJ, Choi EY, Jung JH, et al. An atypical mitral valve prolapse in a patient with Behçet’s disease. Korean Circ J. 2011;41(4):217–9. https://doi.org/10.4070/kcj.2011.41.4.217. Epub 2011 Apr 30. PMID: 21607174; PMCID: PMC3098416.

Article  PubMed  PubMed Central  Google Scholar 

Vahanian A, Beyersdorf F, Praz F, et al. ESC National Cardiac Societies, 2021 ESC/EACTS Guidelines for the management of valvular heart disease: developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2022;43(7):561–632.

Article  PubMed  Google Scholar 

Srinivasan NT, Schilling RJ. Sudden cardiac death and arrhythmias. Arrhythm Electrophysiol Rev. 2018;7(2):111–7. https://doi.org/10.15420/aer.2018:15:2. PMID: 29967683; PMCID: PMC6020177.

Article  PubMed  PubMed Central  Google Scholar 

Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. ESC Scientific Document Group, 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: developed by the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC) Endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2022;43(40):3997–4126.

Article  PubMed  Google Scholar 

Fishman GI, Chugh SS, Dimarco JP, et al. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation. 2010;122(22):2335–48. https://doi.org/10.1161/CIRCULATIONAHA.110.976092. PMID: 21147730; PMCID: PMC3016224.

Article  PubMed  PubMed Central  Google Scholar 

Bekheit SG, Ali AA, Deglin SM, Jain AC. Analysis of QT interval in patients with idiopathic mitral valve prolapse. Chest. 1982 May;81(5):620–5.  https://doi.org/10.1378/chest.81.5.620. PMID: 7075284.

Algra A, Tijssen JG, Roelandt JR, et al. QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation. 1991;83(6):1888–94. https://doi.org/10.1161/01.cir.83.6.1888. PMID: 2040041.

Article  CAS  PubMed  Google Scholar 

O’Neal WT, Singleton MJ, Roberts JD, et al. Association between QT-interval components and sudden cardiac death: the ARIC study (atherosclerosis risk in communities). Circ Arrhythm Electrophysiol. 2017;10(10):e005485. https://doi.org/10.1161/CIRCEP.117.005485. PMID: 29030380; PMCID: PMC5659833.

Article  PubMed  PubMed Central  Google Scholar 

Essayagh B, Sabbag A, Antoine C, et al. Presentation and outcome of arrhythmic mitral valve prolapse. J Am Coll Cardiol. 2020;76(6):637–49. https://doi.org/10.1016/j.jacc.2020.06.029. PMID: 32762897.

Article  PubMed  Google Scholar 

Zouridakis EG, Parthenakis FI, Kochiadakis GE, Kanoupakis EM, Vardas PE. QT dispersion in patients with mitral valve prolapse is related to the echocardiographic degree of the prolapse and mitral leaflet thickness. Europace. 2001;3(4):292–8. https://doi.org/10.1053/eupc.2001.0186. PMID: 11678387.

Article  CAS  PubMed  Google Scholar 

Bhutto ZR, Barron JT, Liebson PR, et al. Am J Cardiol. 1992;70(2):265–6. https://doi.org/10.1016/0002-9149(92)91287-e. PMID: 1626519.

Article  CAS  PubMed  Google Scholar 

Sriram CS, Syed FF, Ferguson ME, et al. Malignant bileaflet mitral valve prolapse syndrome in patients with otherwise idiopathic out-of-hospital cardiac arrest. J Am Coll Cardiol. 2013;62(3):222–30. https://doi.org/10.1016/j.jacc.2013.02.060. Epub 2013 Apr 3 PMID: 23563135.

Article  PubMed  Google Scholar 

Kaya Ü, Eren H. Fragmented QRS may be associated with complex ventricular arrhythmias in mitral valve prolapse. Minerva Cardioangiol. 2020;68(6):577–85. https://doi.org/10.23736/S0026-4725.20.05123-3. Epub 2020 Mar 4 PMID: 32138502.

Article  PubMed  Google Scholar 

•• Sabbag A, Essayagh B, Barrera JDR, et al. EHRA expert consensus statement on arrhythmic mitral valve prolapse and mitral annular disjunction complex in collaboration with the ESC Council on valvular heart disease and the European Association of Cardiovascular Imaging endorsed by the Heart Rhythm Society, by the Asia Pacific Heart Rhythm Society, and by the Latin American Heart Rhythm Society. Europace. 2022;24(12):1981–2003. https://doi.org/10.1093/europace/euac125. The above-mentioned publication is the only official statement of the European Heart Rhythm Association of the European Society of Cardiology that correlates mitral valve prolapse, previously defined as a benign finding, with ventricular arrhythmia and increased risk of sudden cardiac death.

Article  PubMed  Google Scholar 

Han HC, Ha FJ, Teh AW, et al. Mitral valve prolapse and sudden cardiac death: a systematic review. J Am Heart Assoc. 2018;7(23):e010584 https://doi.org/10.1161/JAHA.118.010584 PMID:30486705;PMCID:PMC6405538.

Article  PubMed  PubMed Central  Google Scholar 

Oliveri F, Kakargias F, Panday P, et al. Arrhythmic mitral valve prolapse: diagnostic parameters for high-risk patients: a systematic review and meta-analysis. Pacing Clin Electrophysiol. 2021;44(10):1746–55. https://doi.org/10.1111/pace.14338. Epub 2021 Aug 24 PMID: 34397120.

Article  PubMed  Google Scholar 

Hourdain J, Clavel MA, Deharo JC, et al. Common phenotype in patients with mitral valve prolapse who experienced sudden cardiac death. Circulation. 2018;138(10):1067–9. https://doi.org/10.1161/CIRCULATIONAHA.118.033488. PMID: 30354542.

Article  PubMed  Google Scholar 

Avierinos JF, Gersh BJ, Melton LJ 3rd, et al. Natural history of asymptomatic mitral valve prolapse in the community. Circulation. 2002;106(11):1355–61. https://doi.org/10.1161/01.cir.0000028933.34260.09. PMID: 12221052.

Article  PubMed  Google Scholar 

Vriz O, Eltayeb A, Landi I, et al. Transthoracic echocardiography for arrhythmic mitral valve prolapse: phenotypic characterization as first step. Echocardiography. 2022;39(9):1158–70. https://doi.org/10.1111/echo.15439. Epub 2022 Aug 27 PMID: 36029124.

Article  PubMed  Google Scholar 

Basso C, PerazzoloMarra M, et al. Arrhythmic mitral valve prolapse and sudden cardiac death. Circulation. 2015;132(7):556–66. https://doi.org/10.1161/CIRCULATIONAHA.115.016291. Epub 2015 Jul 9 PMID: 26160859.

Article  PubMed  Google Scholar 

Akcay M, Yuce M, Pala S, et al. Anterior mitral valve length is associated with ventricular tachycardia in patients with classical mitral valve prolapse. Pacing Clin Electrophysiol. 2010;33(10):1224–30. https://doi.org/10.1111/j.1540-8159.2010.02798.x. PMID: 20546149.

Article  PubMed  Google Scholar 

Malev E, Reeva S, Vasina L, et al. Cardiomyopathy in young adults with classic mitral valve prolapse. Cardiol Young. 2014;24(4):694–701. https://doi.org/10.1017/S1047951113001042. Epub 2013 Jul 23 PMID: 23880103.

Article  PubMed  Google Scholar 

Yiginer O, Keser N, Ozmen N, et al. Classic mitral valve prolapse causes enlargement in left ventricle even in the absence of significant mitral regurgitation. Echocardiography. 2012;29(2):123–9. https://doi.org/10.1111/j.1540-8175.2011.01544.x. Epub 2011 Nov 2 PMID: 22044562.

Article  PubMed  Google Scholar 

Yang LT, Ahn SW, Li Z, et al. Mitral valve prolapse patients with less than moderate mitral regurgitation exhibit early cardiac chamber remodeling. J Am Soc Echocardiogr. 2020;33(7):815–25. https://doi.org/10.1016/j.echo.2020.01.016. Epub 2020 Mar 26. PMID: 32222479; PMCID: PMC8193998.

Article  PubMed  PubMed Central  Google Scholar 

El-Tallawi KC, Kitkungvan D, Xu J, et al. Resolving the disproportionate left ventricular enlargement in mitral valve prolapse due to Barlow disease: insights from cardiovascular magnetic resonance. JACC Cardiovasc Imaging. 2021;14(3):573–84. https://doi.org/10.1016/j.jcmg.2020.08.029. Epub 2020 Oct 29 PMID: 33129724.

Article  PubMed  Google Scholar 

Levy F, Iacuzio L, Marechaux S, et al. Influence of prolapse volume in mitral valve prolapse. Am J Cardiol. 2021;15(157):64–70. https://doi.org/10.1016/j.amjcard.2021.07.019. Epub 2021 Aug 10 PMID: 34389154.

Article  Google Scholar 

Luyten P, Heuts S, Cheriex E, et al. Mitral prolapsing volume is associated with increased cardiac dimensions in patients with mitral annular disjunction. Neth Heart J. 2022;30(3):131–9. https://doi.org/10.1007/s12471-021-01575-6. Epub 2021 May 4. PMID: 33945108; PMCID: PMC8881558.

Article  CAS  PubMed  Google Scholar 

Kitkungvan D, Nabi F, Kim RJ, et al. Myocardial Fibrosis in patients with primary mitral regurgitation with and without prolapse. J Am Coll Cardiol. 2018;72(8):823–34. https://doi.org/10.1016/j.jacc.2018.06.048. PMID: 30115220.

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