Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders

Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43:5721–5732

Article  PubMed  PubMed Central  Google Scholar 

Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW (2023) Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies. Chem Rev 123:31–72

Article  CAS  PubMed  Google Scholar 

Agnello L, Ciaccio M (2022) Neurodegenerative diseases: from molecular basis to therapy. Int J Mol Sci 23:12854

Article  PubMed  PubMed Central  Google Scholar 

Ahn EH, Kang SS, Liu X, Chen G, Zhang Z, Chandrasekharan B et al (2020) Initiation of Parkinson’s disease from gut to brain by δ-secretase. Cell Res 30:70–87

Article  PubMed  Google Scholar 

Aizawa E, Tsuji H, Asahara T, Takahashi T, Teraishi T, Yoshida S et al (2016) Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. J Affect Disord 202:254–257

Article  PubMed  Google Scholar 

Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR et al (2016) Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer’s disease: a randomized, double-blind and controlled trial. Front Aging Neurosci  8

Alexander GE (2004) Biology of Parkinson’s disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. Dialogues Clin Neurosci 6:259–280

Article  PubMed  PubMed Central  Google Scholar 

Alonso R, Pisa D, Carrasco L (2019) Brain microbiota in Huntington’s disease patients. Front Microbiol 10:2622

Article  PubMed  PubMed Central  Google Scholar 

Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T et al (2011) MetaHIT Consortium (additional members),  Enterotypes of the human gut microbiome. Nature 473:174–180

Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A et al (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci 101:15718–15723

Article  ADS  PubMed  PubMed Central  Google Scholar 

Bäckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P et al (2015) Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host Microbe 17:852

Article  PubMed  Google Scholar 

Benros ME, Eaton WW, Mortensen PB (2014) The epidemiologic evidence linking autoimmune diseases and psychosis. Biol Psychiatry 75:300–306

Article  PubMed  Google Scholar 

Beqollari D, Romberg CF, Dobrowolny G, Martini M, Voss AA, Musarò A et al (2016) Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis. Skelet Muscle 6:24

Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J et al (2011) The Intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141:599-609.e3

Article  CAS  PubMed  Google Scholar 

Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M et al (2011) Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 35:804–817

Article  CAS  PubMed  Google Scholar 

Bik EM, Eckburg PB, Gill SR, Nelson KE, Purdom EA, Francois F et al (2006) Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci 103:732–737

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Bioque M, González-Rodríguez A, Garcia-Rizo C, Cobo J, Monreal JA, Usall J et al (2021) Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review. Prog Neuropsychopharmacol Biol Psychiatry 105:110130

Article  CAS  PubMed  Google Scholar 

Blacher E, Bashiardes S, Shapiro H, Rothschild D, Mor U, Dori-Bachash M et al (2019) Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature 572:474–480

Article  ADS  CAS  PubMed  Google Scholar 

Blumenstock S, Rodrigues EF, Peters F, Blazquez-Llorca L, Schmidt F, Giese A et al (2017) Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex. EMBO Mol Med 9:716–731

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boddy SL, Giovannelli I, Sassani M, Cooper-Knock J, Snyder MP, Segal E et al (2021) The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS). BMC Med 19:13

Article  PubMed  PubMed Central  Google Scholar 

Bolognini D, Tobin AB, Milligan G, Moss CE (2016) The pharmacology and function of receptors for short-chain fatty acids. Mol Pharmacol 89:388–398

Article  CAS  PubMed  Google Scholar 

Bonfili L, Cecarini V, Gogoi O, Gong C, Cuccioloni M, Angeletti M et al (2021) Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease. FEBS J 288:2836–2855

Article  CAS  PubMed  Google Scholar 

Boullier S, Nougayrède JP, Marchès O, Tasca C, Boury M, Oswald E et al (2003) Genetically engineered enteropathogenic Escherichia coli strain elicits a specific immune response and protects against a virulent challenge. Microbes Infect 5:857–867

Article  CAS  PubMed  Google Scholar 

Bourassa MW, Alim I, Bultman SJ, Ratan RR (2016) Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health? Neurosci Lett 625:56–63

Article  CAS  PubMed  PubMed Central  Google Scholar 

Braak H, Rüb U, Gai WP, Del Tredici K (2003) Idiopathic Parkinson’s disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 110:517–536

Article  CAS  PubMed  Google Scholar 

Braak H, de Vos RAI, Bohl J, Del Tredici K (2006) Gastric α-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology. Neurosci Lett 396:67–72

Article  CAS  PubMed  Google Scholar 

Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M et al (2017) Altered gut microbiome composition and tryptic activity of the 5xFAD Alzheimer’s mouse model. J Alzheimers Dis 56:775–788

Article  CAS  PubMed  Google Scholar 

Brüggemann N, Hagenah J, Stanley K, Klein C, Wang C, Raymond D et al (2011) Substantia nigra hyperechogenicity with LRRK2 G2019S mutations. Mov Disord 26:885–888

Article  PubMed  PubMed Central  Google Scholar 

Bunton-Stasyshyn RKA, Saccon RA, Fratta P, Fisher EMC (2015) SOD1 Function and its implications for amyotrophic lateral sclerosis pathology: new and renascent themes. Neuroscientist 21:519–529

Article  CAS  PubMed  Google Scholar 

Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J et al (2020) C9orf72 suppresses systemic and neural inflammation induced by gut bacteria. Nature 582:89–94

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Cabanas M, Piquemal M, Pistono C, Arnaud S, Rakesh D, Poinama E et al (2020) Correlations between mutant huntingtin aggregates and behavioral changes in R6/1 mice. J Huntingt Dis 9:33–45

Article  CAS  Google Scholar 

Calvani R, Picca A, Lo Monaco MR, Landi F, Bernabei R, Marzetti E (2018) Of microbes and minds: a narrative review on the second brain aging. Front Med 5:53

Article  Google Scholar 

Caminiti SP, Presotto L, Baroncini D, Garibotto V, Moresco RM, Gianolli L et al (2017) Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson’s disease. NeuroImage Clin 14:734–740

Article  PubMed  PubMed Central  Google Scholar 

Cani PD (2018) Human gut microbiome: hopes, threats and promises. Gut 67:1716–1725

Article  CAS  PubMed  Google Scholar 

Casoli T, Di Stefano G, Fattoretti P, Giorgetti B, Balietti M, Lattanzio F et al (2012) Dynamin binding protein gene expression and memory performance in aged rats. Neurobiol Aging 33:618.e15-618.e19

Article  CAS  PubMed  Google Scholar 

Cattaneo A, Cattane N, Galluzzi S, Provasi S, Lopizzo N, Festari C et al (2017) Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging 49:60–68

Article  CAS  PubMed  Google Scholar 

Ceppa FA, Izzo L, Sardelli L, Raimondi I, Tunesi M, Albani D et al (2020) Human gut-microbiota interaction in neurodegenerative disorders and current engineered tools for its modeling. Front Cell Infect Microbiol 10:297

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chand KK, Lee KM, Lee JD, Qiu H, Willis EF, Lavidis NA et al (2018) Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP-43 Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB J 32:2676–2689

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif