Aggarwal S, Mortensen OV (2017) Overview of monoamine transporters. Curr Protoc Pharmacol 79:12.16.1-12.16.17. https://doi.org/10.1002/cpph.32

Article  PubMed  Google Scholar 

Ahsan MJ, Ali A, Ali A, Thiriveedhi A, Bakht MA, Yusuf M, Salahuddin Afzal, O., & Altamimi, A. S. A. (2022) Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders. ACS Omega 7(43):38207–38245. https://doi.org/10.1021/acsomega.2c05339

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barabási AL, Gulbahce N, Loscalzo J (2011) Network medicine: a network-based approach to human disease. Nat Rev Genet 12(1):56–68. https://doi.org/10.1038/nrg2918

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beckstead, R.M. (1996). The life cycle of neurotransmitters. In: A survey of medical neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8570-5_3

Breuer K, Foroushani AK, Laird MR, Chen C, Sribnaia A, Lo R, Winsor GL, Hancock RE, Brinkman FS, Lynn DJ (2013) InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation. Nucleic Acids Res 41(Database issue):D1228–D1233. https://doi.org/10.1093/nar/gks1147

Article  CAS  PubMed  Google Scholar 

Caldera M, Buphamalai P, Müller F, Menche J (2017) Interactome-based approaches to human disease. Curr Opin Syst Biol 3:88–94. https://doi.org/10.1016/j.coisb.2017.04.015

Article  Google Scholar 

Calo L, Wegrzynowicz M, Santivañez-Perez J, Grazia Spillantini M (2016) Synaptic failure and α-synuclein. Movement disorders : official journal of the Movement Disorder Society 31(2):169–177. https://doi.org/10.1002/mds.26479

Article  CAS  PubMed  Google Scholar 

Cha Y, Erez T, Reynolds IJ, Kumar D, Ross J, Koytiger G, Kusko R, Zeskind B, Risso S, Kagan E, Papapetropoulos S, Grossman I, Laifenfeld D (2018) Drug repurposing from the perspective of pharmaceutical companies. Br J Pharmacol 175(2):168–180. https://doi.org/10.1111/bph.13798

Article  CAS  PubMed  Google Scholar 

Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR, Ma’ayan A (2013) Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14:128. https://doi.org/10.1186/1471-2105-14-128

Article  PubMed  PubMed Central  Google Scholar 

Cheng F, Desai RJ, Handy DE, Wang R, Schneeweiss S, Barabási AL, Loscalzo J (2018) Network-based approach to prediction and population-based validation of in silico drug repurposing. Nat Commun 9(1):2691. https://doi.org/10.1038/s41467-018-05116-5

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Cheng F, Lu W, Liu C, Fang J, Hou Y, Handy DE, Wang R, Zhao Y, Yang Y, Huang J, Hill DE, Vidal M, Eng C, Loscalzo J (2019) A genome-wide positioning systems network algorithm for in silico drug repurposing. Nat Commun 10(1):3476. https://doi.org/10.1038/s41467-019-10744-6

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, Hernandez DG, Blauwendraat C, Stone DJ, Eicher J, Parkkinen L, Scholz SW (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet 53(3):294–303. https://doi.org/10.1038/s41588-021-00785-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clough E, Barrett T (2016) The Gene Expression Omnibus database. Methods Mol Biol (Clifton, N.J.) 1418:93–110. https://doi.org/10.1007/978-1-4939-3578-9_5

Article  Google Scholar 

Colom-Cadena M, Pegueroles J, Herrmann AG, Henstridge CM, Muñoz L, Querol-Vilaseca M, Martín-Paniello CS, Luque-Cabecerans J, Clarimon J, Belbin O, Núñez-Llaves R, Blesa R, Smith C, McKenzie CA, Frosch MP, Roe A, Fortea J, Andilla J, Loza-Alvarez P, Gelpi E, Lleó A (2017) Synaptic phosphorylated α-synuclein in dementia with Lewy bodies. Brain : a journal of neurology 140(12):3204–3214. https://doi.org/10.1093/brain/awx275

Article  PubMed  Google Scholar 

Cowley MJ, Pinese M, Kassahn KS, Waddell N, Pearson JV, Grimmond SM, Biankin AV, Hautaniemi S, Wu J (2012) PINA v2.0: mining interactome modules. Nucleic Acids Res 40(Database issue):D862–D865. https://doi.org/10.1093/nar/gkr967

Article  CAS  PubMed  Google Scholar 

Purves D, Augustine GJ, Fitzpatrick D et al. (eds) (2001) Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates.Available from: https://www.ncbi.nlm.nih.gov/books/NBK10799/

Dudley JT, Deshpande T, Butte AJ (2011) Exploiting drug-disease relationships for computational drug repositioning. Brief Bioinform 12(4):303–311. https://doi.org/10.1093/bib/bbr013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fereshtehnejad SM, Damangir S, Cermakova P, Aarsland D, Eriksdotter M, Religa D (2014) Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry. Alzheimer's research & therapy 6(5–8):65. https://doi.org/10.1186/s13195-014-0065-2

Article  CAS  Google Scholar 

Ferman TJ, Boeve BF, Smith GE, Silber MH, Lucas JA, Graff-Radford NR, Dickson DW, Parisi JE, Petersen RC, Ivnik RJ (2002) Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations. Journal of the International Neuropsychological Society : JINS 8(7):907–914. https://doi.org/10.1017/s1355617702870047

Article  PubMed  Google Scholar 

Fiscon G, Paci P (2021) SAveRUNNER: an R-based tool for drug repurposing. BMC Bioinformatics 22(1):150. https://doi.org/10.1186/s12859-021-04076-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fiscon G, Conte F, Farina L, Paci P (2021) SAveRUNNER: a network-based algorithm for drug repurposing and its application to COVID-19. PLoS Comput Biol 17(2). https://doi.org/10.1371/journal.pcbi.1008686

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Fiscon G, Sibilio P, Funari A, Conte F, Paci P (2022) Identification of potential repurposable drugs in Alzheimer’s disease exploiting a bioinformatics analysis. Journal of personalized medicine 12(10):1731. https://doi.org/10.3390/jpm12101731

Article  PubMed  PubMed Central  Google Scholar 

Fritze F, Ehrt U, Hortobagyi T, Ballard C, Aarsland D (2011) Depressive symptoms in Alzheimer’s disease and Lewy body dementia: a one-year follow-up study. Dement Geriatr Cogn Disord 32(2):143–149. https://doi.org/10.1159/000332016

Article  PubMed  Google Scholar 

Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabási AL (2007) The human disease network. Proc Natl Acad Sci USA 104(21):8685–8690. https://doi.org/10.1073/pnas.0701361104

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Hakimi M, Maurer CW (2019) Pseudobulbar affect in Parkinsonian disorders: a review. Journal of movement disorders 12(1):14–21. https://doi.org/10.14802/jmd.18051

Article  PubMed  PubMed Central  Google Scholar 

Hatzopoulos AK (2019) Disease models & mechanisms in the age of big data. Disease models & mechanisms 12(8):dmm041699. https://doi.org/10.1242/dmm.041699

Article  Google Scholar 

Henstridge CM, Pickett E, Spires-Jones TL (2016) Synaptic pathology: a shared mechanism in neurological disease. Ageing Res Rev 28:72–84. https://doi.org/10.1016/j.arr.2016.04.005

Article  CAS  PubMed  Google Scholar 

Hopkins A (2008) Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4:682–690. https://doi.org/10.1038/nchembio.118

Article  CAS  PubMed  Google Scholar 

Jung YJ, Tweedie D, Scerba MT, Greig NH (2019) Neuroinflammation as a factor of neurodegenerative disease: thalidomide analogs as treatments. Frontiers in cell and developmental biology 7:313. https://doi.org/10.3389/fcell.2019.00313

Article  PubMed  PubMed Central  Google Scholar 

Kane JPM, Surendranathan A, Bentley A, Barker SAH, Taylor JP, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, Burn DJ, O’Brien JT (2018) Clinical prevalence of Lewy body dementia. Alzheimer's research & therapy 10(1):19. https://doi.org/10.1186/s13195-018-0350-6

Article  Google Scholar 

Kanehisa M, Furumichi M, Tanabe M, Sato Y, Morishima K (2017) KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 45(D1):D353–D361. https://doi.org/10.1093/nar/gkw1092

Article  CAS  PubMed  Google Scholar 

Karaman B, Sippl W (2019) Computational drug repurposing: current trends. Curr Med Chem 26(28):5389–5409. https://doi.org/10.2174/0929867325666180530100332

Article  CAS  PubMed  Google Scholar 

Kowshik AV, Manoj M, Sowmyanarayan S, Chatterjee J (2023) Drug repurposing: databases and pipelines.CNS Spectrums, 1–4. Advance online publication. https://doi.org/10.1017/S1092852923002365

Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, McDermott MG, Monteiro CD, Gundersen GW, Ma’ayan A (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 44(W1):W90–W97. https://doi.org/10.1093/nar/gkw377

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam B, Hollingdrake E, Kennedy JL, Black SE, Masellis M (2009) Cholinesterase inhibito