Can acetate via FFA receptors contribute to the diabetogenic effect of statins?

Allen SC, Marnotte CDS (2017) Pleiotropic and adverse effects of statins – do epigenetics play a role? J Pharmacol Exp Ther 362:319–326. https://doi.org/10.1124/jpet.117.242081

Article  PubMed  CAS  Google Scholar 

Baul PB, Deepak AD, Kakkar M, Modi S (2020) Effect of atorvastatin on blood ketone levels and glycemic control in patients with type 2 diabetes mellitus: a single arm pilot study. Diabetes Metab Syndr 14:1333–1337. https://doi.org/10.1016/j.dsx.2020.07.020

Article  PubMed  Google Scholar 

Burke AC, Telford DE, Huff MW (2019) Bempedoic acid: effects on lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 30:1–9. https://doi.org/10.1097/MOL.0000000000000565

Article  PubMed  CAS  Google Scholar 

Carmena R, Betteridge DJ (2019) Diabetogenic actions of statins: mechanisms. Curr Atheroscler Rep 21:23. https://doi.org/10.1007/s11883-019-0780-z

Article  PubMed  CAS  Google Scholar 

Liu JL, Segovia I, Yuan XL, Gao ZH (2020) Controversial roles of gut microbiota-derived short-chain fatty acids (SCFAs) on pancreatic β-cell growth and insulin secretion. Int J Mol Sci 21:910. https://doi.org/10.3390/ijms21030910

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ochoa-Rosales C, Portilla-Fernandez E, Nano J, Wilson R, Lehne B, Mishra PP, Gao X, Ghanbari M, Rueda-Ochoa OL, Juvinao-Quintero D, Loh M, Zhang W, Kooner JS, Grabe HJ, Felix SB, Schöttker B, Zhang Y, Gieger C, Müller-Nurasyid M, Heier M, Peters A, Lehtimäki T, Teumer A, Brenner H, Waldenberger M, Ikram MA, van Meurs JBJ, Franco OH, Voortman T, Chambers J, Stricker BH, Muka T (2020) Epigenetic link between statin therapy and type 2 diabetes. Diabetes Care 43:875–884. https://doi.org/10.2337/dc19-1828

Article  PubMed  CAS  Google Scholar 

Rusica M, Sirtori CR, Carugo S, Banach M, Corsini A (2022) Bempedoic acid: for whom and when. Curr Atheroscler Rep 24:791–801. https://doi.org/10.1007/s11883-022-01054-2

Article  CAS  Google Scholar 

Satter N (2023) Statins and diabetes: What are the connections? Best Pract Res Clin Endocrinol Metab 37:101749. https://doi.org/10.1016/j.beem.2023.101749

Article  CAS  Google Scholar 

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood IY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Davey Smith G, Sattar N, Butterworth A, Würtz P (2018) Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation 138:2499–2512. https://doi.org/10.1161/CIRCULATIONAHA.118.034942

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S (2015) Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med 21:173–177. https://doi.org/10.1038/nm.3779

Article  PubMed  CAS  Google Scholar 

Thakker D, Nair S, Pagada A, Jamdade V, Malik A (2016) Statin use and the risk of developing diabetes: a network meta-analysis. Pharmacoepidemiol Drug Saf 25:1131–1149. https://doi.org/10.1002/pds.4020

Article  PubMed  CAS  Google Scholar 

Yang G, Schooling MC (2023) Statins, type 2 diabetes, and body mass index: a univariable and multivariable Mendelian randomization study. J Clin Endocrinol Metab 108:385–396. https://doi.org/10.1210/clinem/dgac562

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif