Short, A. K. & Baram, T. Z. Early-life adversity and neurological disease: age-old questions and novel answers. Nat. Rev. Neurol. 15, 657–669 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Solis-Urra, P. et al. Early life factors, gray matter brain volume and academic performance in overweight/obese children: the activebrains project. Neuroimage 202, 116130 (2019).

Article  PubMed  Google Scholar 

Koshiyama, D. et al. Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence. Neuroimage 220, 117083 (2020).

Article  PubMed  Google Scholar 

Eikenes, L. et al. Being born small for gestational age reduces white matter integrity in adulthood: a prospective cohort study. Pediatr. Res. 72, 649–654 (2012).

Article  PubMed  Google Scholar 

Solis-Urra, P. et al. Early life factors and white matter microstructure in children with overweight and obesity: the activebrains project. Clin. Nutr. 41, 40–48 (2022).

Article  PubMed  Google Scholar 

Niu, W. et al. Breastfeeding improves dynamic reorganization of functional connectivity in preterm infants: a temporal brain network study. Med. Biol. Eng. Comput. 58, 2805–2819 (2020).

Article  PubMed  Google Scholar 

Nassar, R. et al. Gestational age is dimensionally associated with structural brain network abnormalities across development. Cereb. Cortex 29, 2102–2114 (2019).

Article  PubMed  Google Scholar 

Alexander-Bloch, A., Giedd, J. N. & Bullmore, E. Imaging structural co-variance between human brain regions. Nat. Rev. Neurosci. 14, 322–336 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sotiras, A., Resnick, S. M. & Davatzikos, C. Finding imaging patterns of structural covariance via non-negative matrix factorization. Neuroimage 108, 1–16 (2015).

Article  PubMed  Google Scholar 

Nosarti, C. et al. Structural covariance in the cortex of very preterm adolescents: a voxel-based morphometry study. Hum. Brain Mapp. 32, 1615–1625 (2011).

Article  PubMed  Google Scholar 

Scheinost, D. et al. Alterations in anatomical covariance in the prematurely born. Cereb. Cortex 27, 534–543 (2017).

PubMed  Google Scholar 

Blesa, M. et al. Early breast milk exposure modifies brain connectivity in preterm infants. Neuroimage 184, 431–439 (2019).

Article  PubMed  Google Scholar 

Chen, V. C. et al. Brain structural networks and connectomes: the brain-obesity interface and its impact on mental health. Neuropsychiatr. Dis. Treat. 14, 3199–3208 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Augustijn, M. et al. Structural connectivity and weight loss in children with obesity: a study of the “connectobese. Int J. Obes. 43, 2309–2321 (2019).

Article  CAS  Google Scholar 

Kharabian Masouleh, S. et al. Gray matter structural networks are associated with cardiovascular risk factors in healthy older adults. J. Cereb. Blood Flow. Metab. 38, 360–372 (2018).

Article  PubMed  Google Scholar 

Beyer, F. et al. A metabolic obesity profile is associated with decreased gray matter volume in cognitively healthy older adults. Front. Aging Neurosci. 11, 202 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gill, N., Gjelsvik, A., Mercurio, L. Y. & Amanullah, S. Childhood obesity is associated with poor academic skills and coping mechanisms. J. Pediatr. 228, 278–284 (2020).

Cole, T. J. & Lobstein, T. Extended international (Iotf) body mass index cut‐offs for thinness. Overweight Obes. Pediatr. Obes. 7, 284–294 (2012).

CAS  PubMed  Google Scholar 

Cadenas-Sanchez, C. et al. An exercise-based randomized controlled trial on brain, cognition, physical health and mental health in overweight/obese children (activebrains project): rationale, design and methods. Contemp. Clin. Trials 47, 315–324 (2016).

Article  PubMed  Google Scholar 

Woodcock, R. W., McGrew, K. S. & Mather, N. Woodcock-Johnson® Iii Nu Tests of Achievement (Riverside Rolling Meadows, IL, 2001).

Solis-Urra, P. et al. Early life factors and hippocampal functional connectivity in children with overweight/obesity. Pediatr. Obes. 18, e12998 (2023).

Article  PubMed  Google Scholar 

Moore, S. A. et al. Enhancing a somatic maturity prediction model. Med Sci. Sports Exerc. 47, 1755–1764 (2015).

Article  PubMed  Google Scholar 

Huppertz, C. et al. The effects of parental education on exercise behavior in childhood and youth: a study in Dutch and Finnish twins. Scand. J. Med Sci. Sports 27, 1143–1156 (2017).

Article  CAS  PubMed  Google Scholar 

Esteban-Cornejo, I. et al. A whole brain volumetric approach in overweight/obese children: examining the association with different physical fitness components and academic performance. the activebrains project. Neuroimage 159, 346–354 (2017).

Article  PubMed  Google Scholar 

Leger, L. A., Mercier, D., Gadoury, C. & Lambert, J. The multistage 20 metre shuttle run test for aerobic fitness. J. Sports Sci. 6, 93–101 (1988).

Article  CAS  PubMed  Google Scholar 

Sotiras, A. et al. Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion. Proc. Natl Acad. Sci. USA 114, 3527–3532 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ortega, F. B. et al. Effects of an exercise program on brain health outcomes for children with overweight or obesity: the activebrains randomized clinical trial. JAMA Netw. Open 5, e2227893 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc.: Ser. B (Methodol.) 57, 289–300 (1995).

Google Scholar 

Taylor, H. G. et al. Brain volumes in adolescents with very low birth weight: effects on brain structure and associations with neuropsychological outcomes. Dev. Neuropsychol. 36, 96–117 (2011).

Article  PubMed  Google Scholar 

Herrmann, M. J., Tesar, A. K., Beier, J., Berg, M. & Warrings, B. Grey matter alterations in obesity: a meta-analysis of whole-brain studies. Obes. Rev. 20, 464–471 (2019).

Article  PubMed  Google Scholar 

Smucny, J. et al. Brain structure predicts risk for obesity. Appetite 59, 859–865 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Mueller, K. et al. Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: a combined MRI, serum marker and gene expression study. Transl. Psychiatry 2, e200 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, E. Y., Eickhoff, S. B., Giovannetti, T. & Smith, D. V. Obesity is associated with reduced orbitofrontal cortex volume: a coordinate-based meta-analysis. Neuroimage Clin. 28, 102420 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Pascoe, M. J., Melzer, T. R., Horwood, L. J., Woodward, L. J. & Darlow, B. A. Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. Neuroimage Clin. 22, 101780 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Cecil, K. M. et al. Decreased brain volume in adults with childhood lead exposure. PLoS Med. 5, e112 (2008).

Article  PubMed  PubMed Central  Google Scholar 

Amodio, D. M. & Frith, C. D. Meeting of minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 7, 268–277 (2006).

Article  CAS  PubMed  Google Scholar 

Zhang, Y. et al. Connectivity-based parcellation of the human posteromedial cortex. Cereb. Cortex 24, 719–727 (2014).

Article  PubMed  Google Scholar 

Bouyssi-Kobar, M. et al. Regional microstructural organization of the cerebral cortex is affected by preterm birth. Neuroimage Clin. 18, 871–880 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Leung, M. P., Thompson, B., Black, J., Dai, S. & Alsweiler, J. M. The effects of preterm birth on visual development. Clin. Exp. Optom. 101, 4–12 (2018).

Article  PubMed  Google Scholar 

Draganski, B. et al. Evidence for segregated and integrative connectivity patterns in the human basal ganglia. J. Neurosci. 28, 7143–7152 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volpe, J. J. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 8, 110–124 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Alanko, O. et al. Reading and math abilities of Finnish school beginners born very preterm or with very low birth weight. Learn. Individ. Differ. 54, 173–183 (2017).

Article