Allmyr M, Adolfsson-Erici M, McLachlan MS, Sandborgh-Englund G (2006) Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Sci Total Environ 372(1):87–93

Article  CAS  PubMed  Google Scholar 

Allmyr M, Harden F, Toms L-ML, Mueller JF, McLachlan MS, Adolfsson-Erici M, Sandborgh-Englund G (2008) The influence of age and gender on triclosan concentrations in Australian human blood serum. Sci Total Environ 393(1):162–167

Article  CAS  PubMed  Google Scholar 

Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, Schütz M, Bartsch B, Holtmann M, Becker C (2000) Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med 6(5):583–588

Article  CAS  PubMed  Google Scholar 

Brown S, Whalen M (2015) Tributyltin alters secretion of interleukin 1 beta from human immune cells. J Appl Toxicol 35(8):895–908

Article  CAS  PubMed  Google Scholar 

Brown S, Tehrani S, Whalen MM (2017) Dibutyltin-induced alterations of interleukin 1beta secretion from human immune cells. J Appl Toxicol 37(2):181–191

Article  CAS  PubMed  Google Scholar 

Brown S, Boules M, Hamza N, Wang X, Whalen M (2018a) Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin. Arch Toxicol 92(8):2573–2586

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown S, Wilburn W, Martin T, Whalen M (2018b) Butyltin compounds alter secretion of interleukin 6 from human immune cells. J Appl Toxicol 38(2):201–218

Article  CAS  PubMed  Google Scholar 

Calafat AM, Ye X, Wong L-Y, Reidy JA, Needham LL (2008) Urinary concentrations of triclosan in the US population: 2003–2004. Environ Health Perspect 116(3):303–307

Article  CAS  PubMed  Google Scholar 

Cannella B, Raine CS (1995) The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol off J Am Neurol Assoc Child Neurol Soc 37(4):424–435

CAS  Google Scholar 

Chen GY, Nuñez G (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10(12):826–837

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohn BA, Cirillo PM, Terry MB (2019) DDT and breast cancer: prospective study of induction time and susceptibility windows. JNCI J Natl Cancer Inst 111(8):803–810

Article  PubMed  Google Scholar 

Cooper GS, Jones S (2008) Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminants. Environ Health Perspect 116(8):1001–1008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dann AB, Hontela A (2011) Triclosan: environmental exposure, toxicity and mechanisms of action. J Appl Toxicol 31(4):285–311

Article  CAS  PubMed  Google Scholar 

Demaria S, Pikarsky E, Karin M, Coussens LM, Chen Y-C, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E (2010) Cancer and inflammation: promise for biologic therapy. J Immunother 33(4):335–351

Article  PubMed  PubMed Central  Google Scholar 

Dhillon GS, Kaur S, Pulicharla R, Brar SK, Cledón M, Verma M, Surampalli RY (2015) Triclosan: current status, occurrence, environmental risks and bioaccumulation potential. Int J Environ Res Public Health 12(5):5657–5684

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dinarello C (2009) In annual review of immunology. Annu Rev Immunol 27:519–550

Article  CAS  PubMed  Google Scholar 

Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood J Am Soc Hematol 117(14):3720–3732

CAS  Google Scholar 

Dinwiddie MT, Terry PD, Chen J (2014) Recent evidence regarding Triclosan and cancer risk. Int J Environ Res Public Health 11(2):2209–2217

Article  PubMed  PubMed Central  Google Scholar 

Franklin H, Ernest H, Gabriel S (2001) Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 344(12):907–916

Article  Google Scholar 

Gabay C (2006) Interleukin-6 and chronic inflammation. Arthritis Res Ther 8(2):1–6

Google Scholar 

Gaestel M, Kotlyarov A, Kracht M (2009) Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Disc 8(6):480–499

Article  CAS  Google Scholar 

Holm S (1979) A simple sequentially rejective multiple test procedure. Scand J Stat 1979:65–70

Google Scholar 

Hong DS, Angelo LS, Kurzrock R (2007) Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 110(9):1911–1928

Article  CAS  PubMed  Google Scholar 

Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA (2001) Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14(6):705–714

Article  CAS  PubMed  Google Scholar 

Kleiveland CR (2015) Peripheral blood mononuclear cells. Impact Food Bioactives Health in Vitro Ex Vivo Models 2015:161–167

Google Scholar 

Lucas K, Hohlfeld R (1995) Different aspects of cytokines in the immunopathology of multiple scleroosis. Neurology 45(6 Suppl 6):S4–S5

Article  CAS  PubMed  Google Scholar 

Martin TJ, Whalen MM (2017) Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1β) from human immune cells. Arch Toxicol 91:1795–1808

Article  CAS  PubMed  Google Scholar 

Martin TJ, Gabure S, Maise J, Snipes S, Peete M, Whalen MM (2019a) The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells. Environ Toxicol Pharmacol 72:103263

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin TJ, Maise J, Gabure S, Whalen MM (2019b) Exposures to the environmental contaminants pentachlorophenol and dichlorodiphenyltrichloroethane increase production of the proinflammatory cytokine, interleukin-1β, in human immune cells. J Appl Toxicol 39(8):1132–1142

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237–241

Article  CAS  PubMed  Google Scholar 

Meyer TPH, Zehnter I, Hofmann B, Zaisserer J, Burkhart J, Rapp S, Weinauer F, Schmitz J, Illert WE (2005) Filter Buffy Coats (FBC): a source of peripheral blood leukocytes recovered from leukocyte depletion filters. J Immunol Methods 307(1–2):150–166. https://doi.org/10.1016/j.jim.2005.10.004

Article  CAS  PubMed  Google Scholar 

Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A (2010) Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 11(12):1136–1142

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morrall D, McAvoy D, Schatowitz B, Inauen J, Jacob M, Hauk A, Eckhoff W (2004) A field study of triclosan loss rates in river water (Cibolo Creek, TX). Chemosphere 54(5):653–660

Article  CAS  PubMed  Google Scholar 

Moss T, Howes D, Williams FM (2000) Percutaneous penetration and dermal metabolism of triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether). Food Chem Toxicol 38(4):361–370

Article  CAS  PubMed  Google Scholar 

Naitoh Y, Fukata J, Tominaga T, Nakai Y, Tamai S, Mori K, Imura H (1988) Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem Biophys Res Commun 155(3):1459–1463

Article  CAS  PubMed  Google Scholar 

Ridker PM, Rane M (2021) Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease. Circ Res 128(11):1728–1746

Article  CAS  PubMed  Google Scholar 

Rodricks JV, Swenberg JA, Borzelleca JF, Maronpot RR, Shipp AM (2010) Triclosan: A critical review of the experimental data and development of margins of safety for consumer products. Crit Rev Toxicol 40(5):422–484

Article  CAS  PubMed  Google Scholar 

Ruff A, Lewis M, Whalen M (2023) Organotin and organochlorine toxicants activate key translational regulatory proteins in human immune cells. Arch Toxicol 97(2):469–493

Article  CAS  PubMed  Google Scholar