Atypical antipsychotic use does not impact weight gain for individuals with extreme anorexia nervosa: a retrospective case–control study

Attia E, Haiman C, Walsh BT, Flater SR. Does fluoxetine augment the inpatient treatment of anorexia nervosa? Am J Psychiatry. 1998;155(4):548–51.

Article  PubMed  Google Scholar 

Barbarich NC, McConaha CW, Halmi KA, Gendall K, Sunday SR, Gaskill J, La Via M, Frank GK, Brooks S, Plotnicov KH, Kaye WH. Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa. Int J Eat Disord. 2004;35(1):10–5.

Article  PubMed  Google Scholar 

Kaye WH, Nagata T, Weltzin TE, Hsu LK, Sokol MS, McConaha C, Plotnicov KH, Weise J, Deep D. Double-blind placebo-controlled administration of fluoxetine in restricting- and restricting-purging-type anorexia nervosa. Biol Psychiatry. 2001;49(7):644–52.

Article  PubMed  Google Scholar 

Hrdlicka M, Beranova I, Zamecnikova R, Urbanek T. Mirtazapine in the treatment of adolescent anorexia nervosa. Case-control study. Eur Child Adolesc Psychiatry. 2008;17(3):187–9.

Article  PubMed  Google Scholar 

Jaafar NR, Daud TI, Rahman FN, Baharudin A. Mirtazapine for anorexia nervosa with depression. Aust N Z J Psychiatry. 2007;41(9):768–9.

Article  PubMed  Google Scholar 

Schüle C, Sighart C, Hennig J, Laakmann G. Mirtazapine inhibits salivary cortisol concentrations in anorexia nervosa. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(6):1015–9.

Article  PubMed  Google Scholar 

Walsh BT, Kaplan AS, Attia E, Olmsted M, Parides M, Carter JC, Pike KM, Devlin MJ, Woodside B, Roberto CA, Rockert W. Fluoxetine after weight restoration in anorexia nervosa: a randomized controlled trial. JAMA. 2006;295(22):2605–12.

Article  PubMed  Google Scholar 

Attia E, Steinglass JE, Walsh BT, Wang Y, Wu P, Schreyer C, Wildes J, Yilmaz Z, Guarda AS, Kaplan AS, Marcus MD. Olanzapine versus placebo in adult outpatients with anorexia nervosa: a randomized clinical trial. Am J Psychiatry. 2019;176(6):449–56.

Article  PubMed  PubMed Central  Google Scholar 

Muratore AF, Attia E. Current therapeutic approaches to anorexia nervosa: state of the art. Clin Ther. 2021;43(1):85–94.

Article  PubMed  Google Scholar 

Márquez MC, Sánchez JM, Salazar AM, Martínez CV, Valderrama F, Rojas-Gualdrón DF. Efficacy and safety of antipsychotics and antidepressants in the treatment of anorexia nervosa: a systematic review. Rev Colomb Psiquiatr (Engl Ed). 2021;S0034–7450(20):30121–9.

Google Scholar 

Kishi T, Kafantaris V, Sunday S, Sheridan EM, Correll CU. Are antipsychotics effective for the treatment of anorexia nervosa? Results from a systematic review and meta-analysis. J Clin Psychiatry. 2012;73(6):e757–66.

Article  PubMed  Google Scholar 

McKnight RF, Park RJ. Atypical antipsychotics and anorexia nervosa: a review. Eur Eat Disord Rev. 2010;18(1):10–21.

Article  PubMed  Google Scholar 

Davis LE, Attia E. Recent advances in therapies for eating disorders. F1000Res. 2019;8:F1000 Faculty Rev-1693.

Article  PubMed  PubMed Central  Google Scholar 

Marzola E, Desedime N, Giovannone C, Amianto F, Fassino S, Abbate-Daga G. Atypical antipsychotics as augmentation therapy in anorexia nervosa. PLoS ONE. 2015;10(4):e0125569.

Article  PubMed  PubMed Central  Google Scholar 

Frank GK, Shott ME, Hagman JO, Schiel MA, DeGuzman MC, Rossi B. The partial dopamine D2 receptor agonist aripiprazole is associated with weight gain in adolescent anorexia nervosa. Int J Eat Disord. 2017;50(4):447–50.

Article  PubMed  PubMed Central  Google Scholar 

Hagman J, Gralla J, Sigel E, Ellert S, Dodge M, Gardner R, O’Lonergan T, Frank G, Wamboldt MZ. A double-blind, placebo-controlled study of risperidone for the treatment of adolescents and young adults with anorexia nervosa: a pilot study. J Am Acad Child Adolesc Psychiatry. 2011;50(9):915–24.

Article  PubMed  PubMed Central  Google Scholar 

Powers PS, Klabunde M, Kaye W. Double-blind placebo-controlled trial of quetiapine in anorexia nervosa. Eur Eat Disord Rev. 2012;20(4):331–4.

Article  PubMed  PubMed Central  Google Scholar 

Trunko ME, Schwartz TA, Duvvuri V, Kaye WH. Aripiprazole in anorexia nervosa and low-weight bulimia nervosa: case reports. Int J Eat Disord. 2011;44(3):269–75.

Article  PubMed  Google Scholar 

Frank GK. Aripiprazole, a partial dopamine agonist to improve adolescent anorexia nervosa—a case series. Int J Eat Disord. 2016;49(5):529–33.

Article  PubMed  Google Scholar 

Dold M, Aigner M, Klabunde M, et al. Second-generation antipsychotic drugs in anorexia nervosa: a meta-analysis of randomized controlled trials. Psychother Psychosom. 2015;84(2):110–6.

Article  PubMed  Google Scholar 

Kan C, Eid L, Treasure J, Himmerich H. A meta-analysis of dropout and metabolic effects of antipsychotics in anorexia nervosa. Front Psych. 2020;11:208.

Article  Google Scholar 

Kishi T, Kafantaris V, Sunday S, Sheridan EM, Correll CU. Are antipsychotics effective for the treatment of anorexia nervosa? Results from a systematic review and meta-analysis. J Clin Psychiatry. 2012;73:e757–66.

Article  PubMed  Google Scholar 

Lebow J, Sim LA, Erwin PJ, Murad MH. The effect of atypical antipsychotic medications in individuals with anorexia nervosa: a systematic review and meta-analysis. Int J Eat Disord. 2013;46:332–9.

Article  PubMed  Google Scholar 

de Vos J, Houtzager L, Katsaragaki G, van de Berg E, Cuijpers P, Dekker J. Meta-analysis on the efficacy of pharmacotherapy versus placebo on anorexia nervosa. J Eat Disord. 2014;2:27.

Article  PubMed  PubMed Central  Google Scholar 

Alonso-Pedrero L, Bes-Rastrollo M, Marti A. Effects of antidepressant and antipsychotic use on weight gain: a systematic review. Obes Rev. 2019;20(12):1680–90. https://doi.org/10.1111/obr.12934. (Epub 2019 Sep 16).

Article  PubMed  Google Scholar 

Barton BB, Segger F, Fischer K, Obermeier M, Musil R. Update on weight-gain caused by antipsychotics: a systematic review and meta-analysis. Expert Opin Drug Saf. 2020;19(3):295–314.

Article  PubMed  Google Scholar 

Bak M, Drukker M, Cortenraad S, Vandenberk E, Guloksuz S. Antipsychotics result in more weight gain in antipsychotic naive patients than in patients after antipsychotic switch and weight gain is irrespective of psychiatric diagnosis: a meta-analysis. PLoS ONE. 2021;16(2):e0244944.

Article  PubMed  PubMed Central  Google Scholar 

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th edn. 2013.

Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology. 2003;28(3):519–26.

Article  PubMed  Google Scholar 

Stahl SM. Stahl’s essential psychopharmacology: neuroscientific basis and practical applications. 5th ed. Cambridge: Cambridge University Press; 2021.

Book  Google Scholar 

Luna B, Feinglos MN. Drug-induced hyperglycemia. JAMA. 2001;286(16):1945–8.

Article  PubMed  Google Scholar 

Potvin S, Zhornitsky S, Stip E. Antipsychotic-induced changes in blood levels of leptin in schizophrenia: a meta-analysis. Can J Psychiatry. 2015;60(3 Suppl 2):S26-34.

PubMed  PubMed Central  Google Scholar 

Lipkovich I, Citrome L, Perlis R, Deberdt W, Houston JP, Ahl J, Hardy T. Early predictors of substantial weight gain in bipolar patients treated with olanzapine. J Clin Psychopharmacol. 2006;26(3):316–20.

Article  PubMed  Google Scholar 

Gebhardt S, Haberhausen M, Heinzel-Gutenbrunner M, Gebhardt N, Remschmidt H, Krieg JC, Hebebrand J, Theisen FM. Antipsychotic-induced body weight gain: predictors and a systematic categorization of the long-term weight course. J Psychiatr Res. 2009;43(6):620–6.

Article  PubMed  Google Scholar 

Kinon BJ, Basson BR, Gilmore JA, Tollefson GD. Long-term olanzapine treatment: weight change and weight-related health factors in schizophrenia. J Clin Psychiatry. 2001;62(2):92–100.

Article  PubMed  Google Scholar 

Templeman LA, Reynolds GP, Arranz B, San L. Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis. Pharmacogenet Genomics. 2005;15(4):195–200.

Article  PubMed  Google Scholar 

Srisawat U, Reynolds GP, Zhang ZJ, Zhang XR, Arranz B, San L, Dalton CF. Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia. Int J Neuropsychopharmacol. 2014;17(3):485–90.

Article  PubMed  Google Scholar 

Bissada H, Tasca GA, Barber AM, Bradwejn J. Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 2008;165(10):1281–8. https://doi.org/10.1176/appi.ajp.2008.07121900. (Epub 2008 Jun 16).

Article  PubMed  Google Scholar 

Comments (0)

No login
gif