Challenges in meta-analyses with observational studies
Introduction
Systematic reviews and meta-analyses help to establish evidence-based clinical practice and resolve contradictory research outcomes while supporting research planning and prioritisation.1 Therefore, meta-analysis is being increasingly used in most medical fields with the aim to reach an overall understanding of clinical outcomes and their sources of variation. Although synthesis of randomised controlled trials (RCTs) is genera... moreChallenges in meta-analyses with observational studies
Introduction
Systematic reviews and meta-analyses help to establish evidence-based clinical practice and resolve contradictory research outcomes while supporting research planning and prioritisation.1 Therefore, meta-analysis is being increasingly used in most medical fields with the aim to reach an overall understanding of clinical outcomes and their sources of variation. Although synthesis of randomised controlled trials (RCTs) is generally considered as the highest level of clinical evidence, there are several concerns regarding the potential of meta-analysis of observational studies to provide reliable results.2 The reasons making researchers being sceptical with synthesising observational studies are mainly related to the high risk for within-study and across-study biases, as well as to the presence of increased heterogeneity. #articles#journals CN1699 Social Admin medicalpapers.cn1699.com
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