Challenges in meta-analyses with observational studies
Introduction
Systematic reviews and meta-analyses help to establish evidence-based clinical practice and resolve contradictory research outcomes while supporting research planning and prioritisation.1 Therefore, meta-analysis is being increasingly used in most medical fields with the aim to reach an overall understanding of clinical outcomes and their sources of variation. Although synthesis of randomised controlled trials (RCTs) is genera... moreChallenges in meta-analyses with observational studies
Introduction
Systematic reviews and meta-analyses help to establish evidence-based clinical practice and resolve contradictory research outcomes while supporting research planning and prioritisation.1 Therefore, meta-analysis is being increasingly used in most medical fields with the aim to reach an overall understanding of clinical outcomes and their sources of variation. Although synthesis of randomised controlled trials (RCTs) is generally considered as the highest level of clinical evidence, there are several concerns regarding the potential of meta-analysis of observational studies to provide reliable results.2 The reasons making researchers being sceptical with synthesising observational studies are mainly related to the high risk for within-study and across-study biases, as well as to the presence of increased heterogeneity. #articles#journals CN1699 Social Admin medicalpapers.cn1699.com
Evaluation and Care of Patients with Diabetic Retinopathy
Diabetic retinopathy is a leading cause of both moderate and severe vision loss worldwide. Over the past decade, advances in technology have dramatically improved the evaluation, treatment, and visual outcomes of patients with diabetic retinopathy. Current approaches are reviewed. #journals#articles CN1699.com @ medicalpapers.cn1699.com
Mitochondrial Replacement in the Clinic
Mitochondrial replacement is provided in England and Wales to women with mitochondrial disease seeking to have an unaffected child. However, the use of this technique for the treatment of a different condition — infertility — is unproven and yet is being offered at fertility clinics worldwide. #journal#articles CN1699 Social Admin
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