Webb AJS, Werring DJ (2022) New insights into cerebrovascular pathophysiology and hypertension. Stroke 53:1054–1064. https://doi.org/10.1161/STROKEAHA.121.035850

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fuchs FD, Whelton PK (2020) High blood pressure and cardiovascular disease. Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.119.14240

Article  PubMed  Google Scholar 

Zhu Z, Wang P, Ma S (2013) Metabolic hypertension: concept and practice. Front Med 7:201–206. https://doi.org/10.1007/s11684-013-0264-4

Article  PubMed  Google Scholar 

Xu W, Janocha AJ, Erzurum SC (2021) Metabolism in pulmonary hypertension. Annu Rev Physiol 83:551–576. https://doi.org/10.1146/annurev-physiol-031620-123956

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Zhang J, Zhang B et al (2021) Association of blood pressure, white matter lesions, and regional cerebral blood flow. Med Sci Monit 27:e929958. https://doi.org/10.12659/MSM.929958

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christie IN, Windsor R, Mutsaerts HJMM et al (2022) Cerebral perfusion in untreated, controlled, and uncontrolled hypertension. J Cereb Blood Flow Metab 42:2188–2190. https://doi.org/10.1177/0271678X221124644

Article  PubMed  PubMed Central  Google Scholar 

Fujishima M, Ibayashi S, Fujii K, Mori S (1995) Cerebral blood flow and brain function in hypertension. Hypertens Res 18:111–117. https://doi.org/10.1291/hypres.18.111

Article  CAS  PubMed  Google Scholar 

Iwase M, Sandler S, Carlsson PO et al (2001) The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production. Eur J Endocrinol 144:169–178. https://doi.org/10.1530/eje.0.1440169

Article  CAS  PubMed  Google Scholar 

Meissner A (2016) Hypertension and the brain: a risk factor for more than heart disease. Cerebrovasc Dis 42:255–262. https://doi.org/10.1159/000446082

Article  PubMed  Google Scholar 

Tesfamariam B, DeFelice AF (2007) Endothelial injury in the initiation and progression of vascular disorders. Vascul Pharmacol 46:229–237. https://doi.org/10.1016/j.vph.2006.11.005

Article  CAS  PubMed  Google Scholar 

Remuzzi A, Ene-Iordache B (2013) Novel paradigms for dialysis vascular access: upstream hemodynamics and vascular remodeling in dialysis access stenosis. Clin J Am Soc Nephrol 8:2186–2193. https://doi.org/10.2215/CJN.03450413

Article  PubMed  PubMed Central  Google Scholar 

Brinker AM, Ma J, Lipsky PE, Raskin I (2007) Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 68:732–766. https://doi.org/10.1016/j.phytochem.2006.11.029

Article  CAS  PubMed  Google Scholar 

Hua H, Zhang Y, Zhao F et al (2021) Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity. iScience. https://doi.org/10.1016/j.isci.2021.102077

Article  PubMed  PubMed Central  Google Scholar 

Xu S, Feng Y, He W et al (2021) Celastrol in metabolic diseases: progress and application prospects. Pharmacol Res 167:105572. https://doi.org/10.1016/j.phrs.2021.105572

Article  CAS  PubMed  Google Scholar 

Xiao S, Zhang M, Liang Y, Wang D (2017) Celastrol synergizes with oral nifedipine to attenuate hypertension in preeclampsia: a randomized, placebo-controlled, and double blinded trial. J Am Soc Hypertens 11:598–603. https://doi.org/10.1016/j.jash.2017.07.004

Article  CAS  PubMed  Google Scholar 

Yu X, Tao W, Jiang F et al (2010) Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am J Hypertens 23:895–903. https://doi.org/10.1038/ajh.2010.75

Article  CAS  PubMed  Google Scholar 

Li Z, Zhang J, Duan X et al (2022) Celastrol: a promising agent fighting against cardiovascular diseases. Antioxidants. https://doi.org/10.3390/antiox11081597

Article  PubMed  PubMed Central  Google Scholar 

Tan JL, Yi J, Cao XY et al (2023) Celastrol: the new dawn in the treatment of vascular remodeling diseases. Biomed Pharmacother. https://doi.org/10.1016/j.biopha.2022.114177

Article  PubMed  Google Scholar 

Fan J, de Lannoy IAM (2014) Pharmacokinetics. Biochem Pharmacol 87:93–120. https://doi.org/10.1016/j.bcp.2013.09.007

Article  CAS  PubMed  Google Scholar 

Oliveira-Sales EB, Toward MA, Campos RR, Paton JFR (2014) Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in rats. Auton Neurosci 183:23–29. https://doi.org/10.1016/j.autneu.2014.02.001

Article  PubMed  PubMed Central  Google Scholar 

Segawa Y, Hashimoto H, Maruyama S et al (2020) Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension. Clin Exp Hypertens 42:352–359. https://doi.org/10.1080/10641963.2019.1665676

Article  CAS  PubMed  Google Scholar 

Xiao X, Ping N-N, Li S et al (2015) An optimal initial tension for rat basilar artery in wire myography. Microvasc Res 97:156–158. https://doi.org/10.1016/j.mvr.2014.11.001

Article  PubMed  Google Scholar 

Sandhu H, Xu CB, Edvinsson L (2010) Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK. Toxicol Appl Pharmacol 249:25–32. https://doi.org/10.1016/j.taap.2010.08.010

Article  CAS  PubMed  Google Scholar 

Abo Laban AI, El-Bassossy HM, Hassan NA (2022) Hinokitiol produces vasodilation in aortae from normal and angiotensin II-induced hypertensive rats via endothelial-dependent and independent pathways. Vascul Pharmacol. https://doi.org/10.1016/j.vph.2022.107092

Article  PubMed  Google Scholar 

Silva MG, Barbosa SLF, Silva DS et al (2022) Bioactive Natural products against systemic arterial hypertension: a past 20-year systematic and prospective review. Evid Based Complement Altern Med. https://doi.org/10.1155/2022/8499625

Article  Google Scholar 

Ajebli M, Eddouks M (2019) Phytotherapy of Hypertension: an updated overview. Endocr Metab Immune Disord Drug Targets 20:812–839. https://doi.org/10.2174/1871530320666191227104648

Article  CAS  Google Scholar 

Jonas K, Magoń W, Podolec P, Kopeć G (2019) Triglyceride-to-high-density lipoprotein cholesterol ratio and systemic inflammation in patients with idiopathic pulmonary arterial hypertension. Med Sci Monit 25:746–753. https://doi.org/10.12659/MSM.912766

Article  CAS  PubMed  PubMed Central  Google Scholar 

da Silva AA, do CarmoLi JMX et al (2020) Role of hyperinsulinemia and insulin resistance in hypertension: metabolic syndrome revisited. Can J Cardiol 36:671–682. https://doi.org/10.1016/j.cjca.2020.02.066

Article  PubMed  Google Scholar 

Ma X, Xu L, Alberobello AT et al (2015) Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis. Cell Metab 22:695–708. https://doi.org/10.1016/j.cmet.2015.08.005

Article  CAS  PubMed  Google Scholar 

Rupprecht LE, Kreisler AD, Spierling SR et al (2018) Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology 235:1131–1140. https://doi.org/10.1007/s00213-018-4830-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gluvic Z, Zaric B, Resanovic I et al (2017) Link between metabolic syndrome and insulin resistance. Curr Vasc Pharmacol 15:30–39. https://doi.org/10.2174/1570161114666161007164510

Article  CAS  PubMed  Google Scholar 

Lind L, Lithell H (1993) Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia. Am Heart J 125:1494–1497. https://doi.org/10.1016/0002-8703(93)90446-g

Article  CAS  PubMed  Google Scholar 

Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860–867. https://doi.org/10.1038/nature05485

Article  CAS  PubMed  Google Scholar 

Furukawa S, Fujita T, Shimabukuro M et al (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Investig 114:1752–1761. https://doi.org/10.1172/JCI21625

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parsanathan R, Jain SK (2020) Novel invasive and noninvasive cardiac-specific biomarkers in obesity and cardiovascular diseases. Metab Syndr Relat Disord 18:10–30.