Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Marie EJS (2019) Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell 177(1262-1279):e25

Google Scholar 

Amani H, Habibey R, Shokri F, Hajmiresmail SJ, Akhavan O, Mashaghi A, Pazoki-Toroudi H (2019) Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling. Sci Rep 9:6044

Article  PubMed  PubMed Central  Google Scholar 

Amini SM, Pirhajati Mahabadi V (2018) Selenium nanoparticles role in organ systems functionality and disorder. Nanomed Res J 3:117–124

CAS  Google Scholar 

Bieber M, Gronewold J, Scharf A-C, Schuhmann MK, Langhauser F, Hopp S, Mencl S, Geuss E, Leinweber J, Guthmann J (2019) Validity and reliability of neurological scores in mice exposed to middle cerebral artery occlusion. Stroke 50:2875–2882

Article  PubMed  Google Scholar 

Candelario-Jalil E, Dijkhuizen RM, Magnus T (2022) Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities. Stroke 53:1473–1486

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Pang X, Yeo AJ, Xie S, Xiang M, Shi B, Yu G, Li C (2022) The molecular mechanisms of ferroptosis and its role in blood-brain barrier dysfunction. Front Cell Neurosci 16:889765

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui W-H, Zhang H-H, Qu Z-M, Wang Z, Zhang D-J, Wang S (2022) Effects of chrysophanol on hippocampal damage and mitochondrial autophagy in mice with cerebral ischemia reperfusion. Int J Neurosci 132:613–620

Article  CAS  PubMed  Google Scholar 

Deng T, Liu X, He W, Chen J, Yao X, Liu L, Zhang T, Lu H (2023) A comparison of safety and efficacy between long-term DAPT and intensive statins combined with short-term DAPT for acute ischemic stroke. Eur J Med Res 28:154

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dhillon PS, Butt W, Podlasek A, Barrett E, McConachie N, Lenthall R, Nair S, Malik L, James MA, Dineen RA (2023) Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: a propensity score matched cohort study. J Neurointerv Surg 15:233–237

Article  PubMed  Google Scholar 

Du X, Shi Q, Zhao Y, Xie Y, Li X, Liu Q, Iqbal J, Zhang H, Liu X, Shen L (2021) Se-methylselenocysteine (SMC) improves cognitive deficits by attenuating synaptic and metabolic abnormalities in Alzheimer’s mice model: a proteomic study. ACS Chem Neurosci 12:1112–1132

Article  CAS  PubMed  Google Scholar 

Fei Y, Wang S, Yang L, Qiu Y, Li Y, Liu W, Xi T, Fang W, Li Y (2017) Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats. J Ethnopharmacol 207:57–66

Article  PubMed  Google Scholar 

Fei Y, Zhu J, Zhao B, Yin Q, Fang W, Li Y (2020) XQ-1H regulates Wnt/GSK3β/β-catenin pathway and ameliorates the integrity of blood brain barrier in mice with acute ischemic stroke. Brain Res Bull 164:269–288

Article  CAS  PubMed  Google Scholar 

Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, Fisher M, Pandian J, Lindsay P (2022) World Stroke Organization (WSO): global stroke fact sheet 2022. Int J Stroke 17:18–29

Article  PubMed  Google Scholar 

Fordyce FM (2012) Selenium deficiency and toxicity in the environment Essentials of Medical Geology: Revised edition. Springer, pp 375–416

Google Scholar 

Gao X, Chen C, Shi S, Qian F, Liu D, Gong J (2023) Tight junctions in the auditory system: structure, distribution and function. Curr Protein Pept Sci 24:203–214

Article  CAS  PubMed  Google Scholar 

Gawor A, Ruszczynska A, Czauderna M, Bulska E (2020) Determination of selenium species in muscle, heart, and liver tissues of lambs using mass spectrometry methods. Animals 10:808

Article  PubMed  PubMed Central  Google Scholar 

Genchi G, Lauria G, Catalano A, Sinicropi MS, Carocci A (2023) Biological activity of selenium and its impact on human health. Int J Mol Sci 24:2633

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greene C, Hanley N, Campbell M (2019) Claudin-5: gatekeeper of neurological function. Fluids Barriers CNS 16:1–15

Article  Google Scholar 

Gurney KJ, Estrada EY, Rosenberg GA (2006) Blood–brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation. Neurobiol Dis 23:87–96

Article  CAS  PubMed  Google Scholar 

Hao Z, Zhang Z, Zhao Y, Wang D (2023) Baicalin reduces immune cell infiltration by inhibiting inflammation and protecting tight junctions in ischemic stroke injury. Am J Chin Med 51:355–372

Article  CAS  PubMed  Google Scholar 

Ip C, Lisk D, Stoewsand G (1992) Mammary cancer prevention by regular garlic and selenium-enriched garlic. Nutr Cancer 17:279–286

Article  CAS  PubMed  Google Scholar 

Lee J-Y, Castelli V, Kumar N, Sitruk-Ware R, Borlongan CV (2022) Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria. Free Radic Biol Med 183:138–145

Article  CAS  PubMed  Google Scholar 

Li Z, Chen L, Chen C, Zhou Y, Hu D, Yang J, Chen Y, Zhuo W, Mao M, Zhang X (2020) Targeting ferroptosis in breast cancer. Biomark Res 8:1–27

Article  Google Scholar 

Liu S, Fan S, Wang Y, Chen R, Wang Z, Zhang Y, Jiang W, Chen Y, Xu X, Yu Y (2023) ACSL4 serves as a novel prognostic biomarker correlated with immune infiltration in Cholangiocarcinoma. BMC Cancer 23:1–13

CAS  Google Scholar 

Liu X, Mao Y, Huang S, Li W, Zhang W, An J, Jin Y, Guan J, Wu L, Zhou P (2022) Selenium nanoparticles derived from Proteus mirabilis YC801 alleviate oxidative stress and inflammatory response to promote nerve repair in rats with spinal cord injury. Regenerative. Biomaterials 9:rbac042

CAS  Google Scholar 

Minich WB (2022) Selenium metabolism and biosynthesis of selenoproteins in the human body. Biochem Mosc 87:S168–S177

Article  CAS  Google Scholar 

Molagoda IMN, Kang C-H, Lee M-H, Choi YH, Lee C-M, Lee S, Kim G-Y (2021) Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosis. Biochem Pharmacol 192:114676

Article  CAS  PubMed  Google Scholar 

Nian K, Harding IC, Herman IM, Ebong EE (2020) Blood-brain barrier damage in ischemic stroke and its regulation by endothelial mechanotransduction. Front Physiol 11:605398

Article  PubMed  PubMed Central  Google Scholar 

Nicholson JL, Toh P, Alfulaij N, Berry MJ, Torres DJ (2022) New insights on selenoproteins and neuronal function. Free Radic Biol Med 190:55–61

Article  CAS  PubMed  Google Scholar 

O'Collins VE, Macleod MR, Donnan GA, Horky LL, Van Der Worp BH, Howells DW (2006) 1,026 experimental treatments in acute stroke. Ann Neurol 59:467–477

Article  CAS  PubMed  Google Scholar 

Psychogios K, Tsivgoulis G (2022) Intravenous thrombolysis for acute ischemic stroke: why not? Curr Opin Neurol 35:10–17

Article  CAS  PubMed  Google Scholar 

Qin X, Wang J, Chen S, Liu G, Wu C, Lv Q, He X, Bai X, Huang W, Liao H (2022) Astrocytic p75NTR expression provoked by ischemic stroke exacerbates the blood–brain barrier disruption. Glia 70:892–912

Article  CAS  PubMed  Google Scholar 

Ramezani M, Simani L, Abedi S, Pakdaman H (2022) Is selenium supplementation beneficial in acute ischemic stroke? Neurologist 27:51–55

Article  Google Scholar 

Rua RM, Nogales F, Carreras O, Ojeda ML (2023) Selenium, selenoproteins and cancer of the thyroid. J Trace Elem Med Biol 76:127115

Article  CAS  PubMed  Google Scholar 

Schaar KL, Brenneman MM, Savitz SI (2010) Functional assessments in the rodent stroke model. Exp Transl Stroke Med 2:1–11

Article  Google Scholar 

Sharifi-Razavi A, Karimi N, Jafarpour H (2022) Evaluation of selenium supplementation in acute ischemic stroke outcome: an outcome assessor blind, randomized, placebo-controlled, feasibility study. Neurol India 70:87

PubMed  Google Scholar 

Shen Y, Huang H, Wang Y, Yang R, Ke X (2022) Antioxidant effects of Se-glutathione peroxidase in alcoholic liver disease. J Trace Elem Med Biol 74:127048

Sladojevic N, Yu B, Liao JK (2020) Regulator of G-protein signaling 5 maintains brain endothelial cell function in focal cerebral ischemia. J Am Heart Assoc 9:e017533

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spitzer D, Guérit S, Puetz T, Khel MI, Armbrust M, Dunst M, Macas J, Zinke J, Devraj G, Jia X (2022) Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke. Acta Neuropathol 144:305–337

Article  CAS  PubMed  PubMed Central  Google Scholar 

Staneviciene I, Levinas D, Sadauskiene I, Liekis A, Viezeliene D, Kursvietiene L, Naginiene R, Baranauskiene D, Simakauskiene V, Vaitkiene P (2023) Effect of organic selenium on the homeostasis of trace elements, lipid peroxidation, and mRNA expression of antioxidant proteins in mouse organs. Int J Mol Sci 24:9704

Article  CAS  Pub