Dobson R, Giovannoni G. Multiple sclerosis–a review. Eur J Neurol. 2019;26:27–40.

Article  CAS  PubMed  Google Scholar 

Ghasemi N, Razavi S, Nikzad E. Multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy. Cell J. 2017;19:1–10.

PubMed  Google Scholar 

Hauser SL, Cree BAC. Treatment of multiple sclerosis: a review. Am J Med. 2020;133:1380-90.e2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hicks MR, Pyle AD. The emergence of the stem cell niche. Trends Cell Biol. 2022. https://doi.org/10.1016/j.tcb.2022.07.003.

Article  PubMed  PubMed Central  Google Scholar 

Biehl JK, Russell B. Introduction to stem cell therapy. J Cardiovasc Nurs. 2009;24:98–103.

Article  PubMed  PubMed Central  Google Scholar 

Mahla RS. Stem cells applications in regenerative medicine and disease therapeutics. Int J Cell Biol. 2016;2016:1–24.

Article  Google Scholar 

Chang C-Y, Ting H-C, Liu C-A, et al. Induced pluripotent stem cell (iPSC)-based neurodegenerative disease models for phenotype recapitulation and drug screening. Molecules. 2020;25:2000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker CL, Pera MF. Capturing totipotent stem cells. Cell Stem Cell. 2018;22:25–34.

Article  CAS  PubMed  Google Scholar 

O’Connell AE, Guseh S, Lapteva L, et al. Gene and stem cell therapies for fetal care. JAMA Pediatr. 2020;174:985.

Article  PubMed  PubMed Central  Google Scholar 

Gonzalez MA, Bernad A. Characteristics of adult stem cells. Adv Exp Med Biol. 2012;741:103–20. https://doi.org/10.1007/978-1-4614-2098-9_8.

Article  CAS  PubMed  Google Scholar 

Dulak J, Szade K, Szade A, et al. Adult stem cells: hopes and hypes of regenerative medicine. Acta Biochim Pol. 2015;62:329–37.

Article  CAS  PubMed  Google Scholar 

Sivandzade F, Cucullo L. Regenerative stem cell therapy for neurodegenerative diseases: an overview. Int JMol Sci. 2021;22(4):2153. https://doi.org/10.3390/ijms22042153.

Article  CAS  Google Scholar 

Xiao J, Yang R, Biswas S, et al. Neural stem cell-based regenerative approaches for the treatment of multiple sclerosis. Mol Neurobiol. 2018;55:3152–71.

Article  CAS  PubMed  Google Scholar 

Ng AP, Alexander WS. Haematopoietic stem cells: past, present and future. Cell Death Discov. 2017;3:17002.

Article  PubMed  PubMed Central  Google Scholar 

Muraro PA, Martin R, Mancardi GL, et al. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis. Nat Rev Neurol. 2017;13:391–405.

Article  CAS  PubMed  Google Scholar 

Burt RK, Padilla J, Begolka WS, et al. Effect of disease stage on clinical outcome after syngeneic bone marrow transplantation for relapsing experimental autoimmune encephalomyelitis. Blood. 1998;91:2609–16.

Article  CAS  PubMed  Google Scholar 

Karussis DM, Vourka-Karussis U, Lehmann D, et al. Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation. J Clin Investig. 1993;92:765–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mancardi GL, Sormani MP, Gualandi F, et al. Autologous hematopoietic stem cell transplantation in multiple sclerosis: a phase II trial. Neurology. 2015;84:981–8.

Article  CAS  PubMed  Google Scholar 

Genc B, Bozan HR, Genc S, Genc K. Stem Cell Therapy for Multiple Sclerosis. Adv Exp Med Biol. 2019;1084:145–74. https://doi.org/10.1007/5584_2018_247.

Article  CAS  PubMed  Google Scholar 

Goolsby J, Makar T, Dhib-Jalbut S, et al. Hematopoietic progenitors express myelin basic protein and ensheath axons in Shiverer brain. J Neuroimmunol. 2013;257:13–20.

Article  CAS  PubMed  Google Scholar 

Harris KM, Lim N, Lindau P, et al. Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis. JCI Insight. 2020. https://doi.org/10.1172/jci.insight.127655.

Article  PubMed  PubMed Central  Google Scholar 

Smith JA, Nicaise AM, Ionescu R-B, et al. Stem cell therapies for progressive multiple sclerosis. Front Cell Dev Biol. 2021. https://doi.org/10.3389/fcell.2021.696434.

Article  PubMed  PubMed Central  Google Scholar 

Siatskas C, Payne NL, Short MA, et al. A Consensus Statement Addressing Mesenchymal Stem Cell Transplantation for Multiple Sclerosis: It’s Time! Stem Cell Rev Rep [Internet]. 2010;6:500–06. Available from: http://link.springer.com/https://doi.org/10.1007/s12015-010-9173-y.

Rice CM, Scolding NJ. Adult human mesenchymal cells proliferate and migrate in response to chemokines expressed in demyelination. Cell Adh Migr. 2010;4:235–40.

Article  PubMed  PubMed Central  Google Scholar 

Munoz JR, Stoutenger BR, Robinson AP, et al. Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proc Natl Acad Sci. 2005;102:18171–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dori I, Petrakis S, Giannakopoulou A, et al. Seven days post-injury fate and effects of genetically labelled adipose-derived mesenchymal cells on a rat traumatic brain injury experimental model. Histol Histopathol. 2017;32:1041–55.

CAS  PubMed  Google Scholar 

Bai L, Lennon DP, Eaton V, et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia. 2009;57:1192–203.

Article  PubMed  PubMed Central  Google Scholar 

Branscome H, Paul S, Yin D, et al. Use of stem cell extracellular vesicles as a “Holistic” approach to CNS repair. Front Cell Dev Biol. 2020. https://doi.org/10.3389/fcell.2020.00455.

Article  PubMed  PubMed Central  Google Scholar 

Kemp K, Gray E, Wilkins A, et al. Purkinje cell fusion and binucleate heterokaryon formation in multiple sclerosis cerebellum. Brain. 2012;135:2962–72.

Article  Google Scholar 

Li C, Cheung MKH, Han S, et al. Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword. 2019. Biosci Rep. https://doi.org/10.1042/BSR20182417.

Sarkar P, Rice CM, Scolding NJ. Cell therapy for multiple sclerosis. CNS Drugs. 2017;31:453–69.

Article  CAS  PubMed  Google Scholar 

Gerdoni E, Gallo B, Casazza S, et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol. 2007;61:219–27.

Article  CAS  PubMed  Google Scholar 

Grigoriadis N, Lourbopoulos A, Lagoudaki R, et al. Variable behavior and complications of autologous bone marrow mesenchymal stem cells transplanted in experimental autoimmune encephalomyelitis. Exp Neurol. 2011;230:78–89.

Article  PubMed  Google Scholar 

Harris VK, Yan QJ, Vyshkina T, et al. Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis. J Neurol Sci. 2012;313:167–77.

Article  PubMed  Google Scholar 

Jiang H, Zhang Y, Tian K, et al. Amelioration of experimental autoimmune encephalomyelitis through transplantation of placental derived mesenchymal stem cells. Sci Rep. 2017;7:41837.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kassis I, Grigoriadis N, Gowda-Kurkalli B, et al. Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis. Arch Neurol. 2008. https://doi.org/10.1001/archneur.65.6.753.

Article  PubMed  Google Scholar 

Zhang J, Li Y, Chen J, et al. Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Exp Neurol. 2005;195:16–26.

Article  CAS  PubMed  Google Scholar 

Gordon D, Pavlovska G, Glover CP, et al. Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration. Neurosci Lett. 2008;448:71–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Li Y, Lu M, et al. Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice. J Neurosci Res. 2006;84:587–95.

Article  CAS  PubMed